Cited by 220Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Role of visceral adipose tissue in aging

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Huffman, Derek M., Barzilai, Nir·2009·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/j.bbagen.2009.01.008PMC PMC2779572

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Abstract

Background Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes, cardiovascular disease, metabolic syndrome and death.Methods Studies utilizing novel rodent models of visceral obesity and surgical strategies in humans have been undertaken to determine if subcutaneous (SC) abdominal or VF are causally linked to age-related diseases.Results Specific depletion or expansion of the VF depot using genetic or surgical tools in rodents has been shown to have direct effects on disease risk. In contrast, surgically removing large quantities of SC fat does not consistently improve metabolic parameters in humans or rodents, while benefits were observed with SC fat expansion in mice, suggesting that SC fat accrual is not an important contributor to metabolic decline. There is also compelling evidence in humans that abdominal obesity is a stronger risk factor for mortality risk than general obesity. Likewise, we have shown that surgical removal of VF improves mean and maximum lifespan in rats, providing the first causal evidence that VF depletion may be an important underlying cause of improved lifespan with caloric restriction.General significance This review provides both corollary and causal evidence for the importance of accounting for body fat distribution, and specifically VF, when assessing disease and mortality risk. Given the hazards of VF accumulation on health, treatment strategies aimed at selectively depleting VF should be considered as a viable tool to effectively reduce disease risk in humans.

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Authors: Huffman, D. M., & Barzilai, N.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Barzilai, Nir
ORCID: Huffman, Derek M.
Barzilai, Nir
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 2009-10
Volume: 1790
Issue: 10
Pages: 1117-1123
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/j.bbagen.2009.01.008
PMC: PMC2779572
OpenAlex: W2082168176
Cited by: 220
References: 89
Citations by year: 2026: 10 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 13 · 2021: 12 · 2020: 17 · 2019: 8 · 2018: 13 · 2017: 7 · 2016: 14 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 18
FWCI: 1.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (P01AG021654, AG 21654, AG18381, T32AG23475, R01AG018381, R37AG018381, T32AG023475)
National Institute of Diabetes and Digestive and Kidney Diseases (DK20541, P60DK020541, P30DK020541)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: visceral adipose tissue, aging, abdominal obesity, subcutaneous adipose tissue, body fat distribution, insulin resistance, type 2 diabetes, metabolic syndrome, cardiovascular disease, mortality risk, lifespan, caloric restriction, bariatric surgery, rodent models
MeSH terms: Aging, Alzheimer Disease, Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Models, Biological, Neoplasms, Intra-Abdominal Fat

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