FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca 2+ /CREB pathway
Open accessAbstract
Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle-stimulating hormone (FSH), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle-stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo. The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as a result, Ca(2+) influx is stimulated, cAMP-response-element-binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of FSH receptor-mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.
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The accumulation of fat during ageing is associated with higher levels of follicle-stimulating hormone (FSH) in both men and women.
“Another interesting paper has associated the accumulation of fat during ageing with higher levels of follicle-stimulating hormone (FSH) in both men and women (Liu et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Liu et al., 2015
Accumulation of fat during ageing is associated with higher levels of FSH in both men and women.
“the accumulation of fat during ageing with higher levels of follicle-stimulating hormone (FSH) in both men and women (Liu et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Liu et al., 2015
Accumulation of fat in heart, liver and skeletal muscle during ageing has been attributed to FSH rise since skeletal muscle and liver express FSH-receptor.
“The accumulation of fat in heart, liver and skeletal muscle during ageing has been also attributed to the FSH rise since skeletal muscle and liver also express FSH-receptor (Liu et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Liu et al., 2015
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“Furthermore, FSH elicited a stronger effect on the cell size of visceral fat than on the cell size of subcutaneous fat; this result possibly indicated the shift from subcutaneous fat to visceral fat accumulation commonly observed in aging populations (Cartwright et al., 2007).”
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- Authors
- Liu, X., Chan, H. C., Ding, G., Cai, J., Song, Y., Wang, T., Zhang, D., Chen, H., Yu, M. K., Wu, Y., Qu, F., Liu, Y., Lu, Y., Adashi, E. Y., Sheng, J., & Huang, H.
- Affiliations
- Chinese University of Hong Kong (HK)
- Jinan University (CN)
- International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai China
- The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou China
- Shanghai Jiao Tong University (CN)
- Brown University (US)
- Zhejiang University (CN)
- Corresponding author
- Sheng, Jian‐Zhong
- Huang, He‐Feng
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2015-03-06
- Volume
- 14
- Issue
- 3
- Pages
- 409-420
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC4406670
- OpenAlex
- W2043998420
- Cited by
- 164
- References
- 48
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 17 · 2023: 23 · 2022: 18 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 18 · 2017: 12 · 2016: 5 · 2015: 1
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Major Program of National Natural Science Fundation of China (81490742)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- follicle-stimulating hormone, FSH receptor, fat deposition, fat redistribution, aging, Gi protein, calcium signaling, CREB phosphorylation, lipogenesis, lipid droplet formation, leptin secretion, adiponectin secretion, adipose tissue, lipodystrophy, sex hormones
- MeSH terms
- Adipose Tissue, Aged, Aging, Animals, Calcium, Female, Follicle Stimulating Hormone, Humans, Male, Middle Aged, Phosphorylation, Receptors, FSH, Signal Transduction, Cyclic AMP Response Element-Binding Protein, GTP-Binding Protein alpha Subunits, Gi-Go, Mice
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