YAP transcriptionally regulates ErbB2 to promote liver cell proliferation
Abstract
The Hippo signaling pathway is implicated in regulation of liver size and dysregulation of this pathway contributes to tumorigenesis. The transcriptional targets and downstream pathways of the Hippo pathway effector YAP that contribute to liver growth have yet to be well-characterized. We examined the liver transcriptome in response to YAP overexpression and identify the ErbB signaling pathway as a mediator of cell growth downstream of YAP. ErbB2 is transcriptionally regulated by YAP in both the mouse liver and in HepG2 human hepatoma cells. Knockdown of YAP or pharmacological inhibition with verteporfin reduced ERBB2 levels in HepG2 cells. Analysis of ChIP-seq data revealed enrichment of the transcription factor TEAD4 at the ERBB2 promoter. Using luciferase reporter and chromatin immunoprecipitation assays, we show that YAP and TEAD4 directly bind to and activate a regulatory element in the ErbB2 promoter in both the mouse liver and HepG2 cells. Functionally, knockdown of YAP reduced EGF-induced ERBB2-mediated HepG2 cell proliferation and PI3K/AKT activation. Our findings highlight a mechanism by which YAP exerts its effects on liver cell proliferation through the ErbB signaling pathway by directly regulating the transcription of ErbB2.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Global cancer statistics, 2012
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21262 · Cited by 26,858 · see citing works
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668 · see citing works
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898 · see citing works
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works
YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works
The Biology of YAP/TAZ: Hippo Signaling and Beyond
Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628 · see citing works
Graus-Porta, D., Beerli, R. R., Daly, J. M., & Hynes, N. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1647 · Cited by 1,593 · see citing works
Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452 · see citing works
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works
The emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,156 · see citing works
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065 · see citing works
Hippo signaling: growth control and beyond
Halder, G. A., & Johnson, R. L. (2010) · Development · doi:10.1242/dev.045500 · Cited by 1,061 · see citing works
Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B. J., & Yarden, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5276 · Cited by 1,039 · see citing works
ErbB receptors and signaling pathways in cancer
Hynes, N. E., & MacDonald, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.010 · Cited by 956 · see citing works
Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works
Hippo Pathway Activity Influences Liver Cell Fate
Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857 · see citing works
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804 · see citing works
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721 · see citing works
Focal Gains of <i>VEGFA</i> and Molecular Classification of Hepatocellular Carcinoma
Chiang, D. Y., Villanueva, A., Hoshida, Y., Peix, J., Newell, P., Minguez, B., LeBlanc, A. C., Donovan, D. J., Thung, S. N., Solé, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0742 · Cited by 719 · see citing works
The E2F transcriptional network: old acquaintances with new faces
Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715 · see citing works
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
Song, H., Mak, K. K., Topol, L. Z., Yun, K., Hu, J., Garrett, L. J., Chen, Y., Park, O., Chang, J., Simpson, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911409107 · Cited by 583 · see citing works
Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 494 · see citing works
Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 427 · see citing works
Kreamer, B. L., Staecker, J. L., Sawada, N., Sattler, G. L., Hsia, M. T. S., & Pitot, H. C. (1986) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623304 · Cited by 383 · see citing works
Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites
Gertz, J., Savic, D., Varley, K. E., Partridge, E. C., Safi, A., Jain, P., Cooper, G. M., Reddy, T. E., Crawford, G. E., & Myers, R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.037 · Cited by 363 · see citing works
Fan, R., Kim, N., & Gumbiner, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216462110 · Cited by 339 · see citing works
Regulation of the Hippo Pathway Transcription Factor TEAD
Lin, K. C., Park, H. W., & Guan, K. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.09.003 · Cited by 334 · see citing works
Song, S., Honjo, S., Jin, J., Chang, S.-S., Scott, A. W., Chen, Q., Kalhor, N., Correa, A. M., Hofstetter, W. L., Albarracin, C. T., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2191 · Cited by 274 · see citing works
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269 · see citing works
Bosher, J. M., Williams, T., & Hurst, H. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.744 · Cited by 229 · see citing works
Lee, D.-H., Park, J. O., Kim, T.-S., Kim, S.-K., Kim, T.-H., Kim, M.-C., Park, G. S., Kim, J.-H., Kuninaka, S., Olson, E. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11961 · Cited by 196 · see citing works
Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration
Lu, L., Finegold, M. J., & Johnson, R. L. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.205 · Cited by 190 · see citing works
Zhang, T., Zhang, J., You, X., Liu, Q., Du, Y., Gao, Y., Shan, C., Kong, G., Wang, Y., Yang, X. Y., et al. (2012) · Hepatology · doi:10.1002/hep.25899 · Cited by 182 · see citing works
Wu, J., Lee, C., Yokom, D. W., Jiang, H., Cheang, M. C. U., Yorida, E., Turbin, D. A., Berquin, I. M., Mertens, P. R., Iftner, T., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3561 · Cited by 159 · see citing works
Wederell, E. D., Bilenky, M., Cullum, R., Thiessen, N., Dagpinar, M., Delaney, A., Varhol, R., Zhao, Y., Zeng, T., Bernier, B., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn382 · Cited by 150 · see citing works
Self-citationThe role of EGF ‐ EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment
Huang, P., Xu, X., Wang, L., Zhu, B., Wang, X., & Xia, J. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12153 · Cited by 123 · see citing works
Hoffman, B. G., Robertson, G., Zavaglia, B., Beach, M., Cullum, R., Lee, S., Soukhatcheva, G., Li, L., Wederell, E. D., Thiessen, N., et al. (2010) · Genome Research · doi:10.1101/gr.104356.109 · Cited by 115 · see citing works
Self-citationHe, C., Lv, X., Hua, G., Lele, S. M., Remmenga, S. W., Dong, J., Davis, J. S., & Wang, C. (2015) · Oncogene · doi:10.1038/onc.2015.52 · Cited by 114 · see citing works
Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation
Alder, O., Cullum, R., Lee, S., Kan, A. C., Wei, W., Yi, Y., Garside, V. C., Bilenky, M., Griffith, M., Morrissy, A. S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.046 · Cited by 113 · see citing works
Self-citationDiverse expression of ErbB receptor proteins during rat liver development and regeneration
Carver, R. S., Stevenson, M. C., Scheving, L. A., & Russell, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37060 · Cited by 111 · see citing works
Ets regulation of the erbB2 promoter
Scott, G. K., Chang, C.-H., Erny-Albrecht, K. M., Xu, F., Fredericks, W. J., Rauscher, F. J., Thor, A. D., & Benz, C. C. (2000) · Oncogene · doi:10.1038/sj.onc.1204041 · Cited by 76 · see citing works
Cai, W., Lin, L., Hao, H., Zhang, S., Ma, F., Hong, X., Zhang, H., Liu, Q., Ye, G., Sun, G., et al. (2016) · Hepatology · doi:10.1002/hep.28911 · Cited by 76 · see citing works
Wang, C., Gu, C., Jeong, K. J., Zhang, D., Guo, W., Lu, Y., Ju, Z., Panupinthu, N., Yang, J. Y., Gagea, M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-15-3084 · Cited by 58 · see citing works
Liu, J., Ahiekpor, A., Li, L., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24580 · Cited by 43 · see citing works
Nguyen, Q. P., Anders, R. A., Alpini, G. D., & Bai, H. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.05.011 · Cited by 29 · see citing works
A new cis element is involved in the HER2 gene overexpression in human breast cancer cells.
Grooteclaes, M., Vernimmen, D., Plaza, S., Pasleau, F., Hodzic, D. M., & Winkler-Gol, R. (1999) · PubMed · Cited by 28 · see citing works
Nolens, G., Pignon, J., Koopmansch, B., et al. (2009) · Breast Cancer Research · doi:10.1186/bcr2450 · Cited by 28 · see citing works
Wu, Y., Zhang, J., Zhang, H., & Zhai, Y. (2016) · Oncology Letters · doi:10.3892/ol.2016.4885 · Cited by 24 · see citing works
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
IGF2BP2 promotes the progression of colorectal cancer through a YAP‐dependent mechanism
Cui, J., Tian, J., Wang, W., He, T., Li, X., Gu, C., Wang, L., Wu, J., & Shang, A. (2021) · Cancer Science · doi:10.1111/cas.15083 · Cited by 90 · see citing works
The hippo pathway: A master regulator of liver metabolism, regeneration, and disease
Nguyen‐Lefebvre, A. T., Selzner, N., Wrana, J. L., & Bhat, M. (2021) · The FASEB Journal · doi:10.1096/fj.202002284rr · Cited by 58 · see citing works
Fan, Z., Kong, M., Li, M., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00259 · Cited by 40 · see citing works
Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway
Xiao, W., Jia, Y., Lou, H., et al. (2019) · Oncology Reports · doi:10.3892/or.2019.7370 · Cited by 28 · see citing works
“Although the connection between YAP and the PI3K/AKT/mTOR pathway has previously been demonstrated in other cancers (18,19), these results of the present study depicted the regulation between YAP and the PI3K/AKT/mTOR pathway in OC.”
BackgroundWu, L., Zhang, Q., Liang, W., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6623791 · Cited by 25 · see citing works
Signalling pathways and transcriptional regulators orchestrating liver development and cancer
Campbell, S. A., Stephan, T. L., Lotto, J., Cullum, R., Drissler, S., & Hoodless, P. A. (2021) · Development · doi:10.1242/dev.199814 · Cited by 22 · see citing works
Self-citationPan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC
Li, F., Feng, Y., Jiang, Q., Zhang, J., Wu, F., Li, Q., Jing, X., Wang, X., & Huang, C. Y. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120327 · Cited by 23 · see citing works
Luo, G., Sun, Z., Liu, H., Yuan, Z., Wang, W., Tu, B., Li, J., & Fan, C. (2023) · The FASEB Journal · doi:10.1096/fj.202300568r · Cited by 20 · see citing works
Mechano-Signaling Aspects of Hepatocellular Carcinoma
Passi, M., & Stefan Zahler, A. (2021) · Journal of Cancer · doi:10.7150/jca.60102 · Cited by 19 · see citing works
Mranda, G. M., Xiang, Z., Liu, J., Tian, W., & Ding, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.937957 · Cited by 17 · see citing works
Zhang, G., Wang, Y., Fuchs, B. C., Guo, W., Drum, D. L., Erstad, D. J., Shi, B., DeLeo, A. B., Zheng, H. W., Cai, L., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.913736 · Cited by 16 · see citing works
“Independently of ALDH expression, HCSCs were also identi fi ed through the sphere formation of single tumor cells, a surrogate marker for the CSC-associated activity of self-renewal, as well as expression of the stemness genes SOX9 (19), HER2 (20, 21), and c-Myc (22).”
Liu, S., Wang, R., Lou, Y., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/4863015 · Cited by 16 · see citing works
“Yap directly regulates the transcription of ERBB2 and influences the proliferation of hepatocytes through ERBB2 signaling pathway [37].”
BackgroundLiu, M., Du, Q., Mao, G., Dai, N., & Zhang, F. (2022) · Bioengineered · doi:10.1080/21655979.2021.2017630 · Cited by 16 · see citing works
“ChIP experiments were conducted following the methods described previously [28].”
MethodLiu, M., Hu, W., Meng, X., & Wang, B. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189050 · Cited by 13 · see citing works
Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish
Xu, H., Guo, W., Chi, Y.-Y., Kou, Y.-X., & Li, Y. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100857 · Cited by 7 · see citing works
Lee, E., Moon, J.-Y., Ko, J., Park, S., & Im, G. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4893 · Cited by 5 · see citing works
“(61,62) Metabolomic analysis between ASCs transfected with control vector and those with GSTT1 showed signi fi cant changes in metabolites.”
Ma, J., & Huang, X. (2021) · PubMed · doi:10.11817/j.issn.1672-7347.2021.200243 · Cited by 4 · see citing works
Li, X. F., Zhang, N., Li, P.-Q., Chu, H.-Q., Zhao, D. H., Qin, W. D., Gong, S., & Cao, H. (2025) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/0115748928383622250729144741 · Cited by 1 · see citing works
YAP/TAZ-mediated resistance to EGFR inhibitors
Yamaguchi, H., & Taouk, G. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822833-3.00004-8 · Cited by 1 · see citing works
Ryu, Y., Son, H.-J., Hwang, J. S., Noh, K. B., Oh, S., Choi, E., & Shin, Y. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-13656-2 · Cited by 1 · see citing works
“…pathway, translocate to the nucleus and interact with transcription factors to regulate the expression of genes associated with cell adhesion molecules, ECM components, and cytoskeletal dynamics 67–69 , influencing processes fundamental to cell proliferation, survival, and differentiation 70,71 .”
Liu, L., Ke, M., Shang, C., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-602611/v1
New Insights into the Roles of the Hippo Signaling Pathway in Stem Cell Biology
Nilchi, A. N., Dehghanian, F., Khalilian, S., & Imani, S. Z. H. (2023) · Jentashapir Journal of Cellular and Molecular Biology · doi:10.5812/jjcmb-136938 · Cited by 1 · see citing works
“Historic studies verified the HSP’s physiological significance in mammalian liver using mouse models that conditionally overexpress YAP in hepatocytes (46).”
BackgroundZhang, N., Xu, L. U., He, J.-X., & Ye, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-20072-z
Jiang, C., Liu, T., Dai, Z., et al. (2026) · Nature Cardiovascular Research · doi:10.1038/s44161-026-00841-3
“7d), supporting a role for YAP1 in promoting the upregulation of these receptors under low mechanical loading 14,15 .”
- Authors
- Wang, E. Y., Cheng, J.-C., Thakur, A., Yi, Y., Tsai, S.-H., & Hoodless, P. A.
- Affiliations
- BC Cancer Agency (CA)
- Corresponding author
- Hoodless, Pamela A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 1861
- Issue
- 9
- Pages
- 854-863
- ISSN
- 1874-9399 (ISSN-L)
- OpenAlex
- W2884014489
- Cited by
- 24
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Michael Smith Health Research BC
- Cancer Research Society (21466)
- Canadian Institutes of Health Research (FRN-259575, PJT-153006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- YAP, ERBB2, Hippo signaling pathway, liver cell proliferation, TEAD4, transcriptional regulation, EGF signaling, PI3K/Akt, hepatocellular carcinoma, liver growth, verteporfin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review