The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Abstract
While the link between obesity and type 2 diabetes is clear on an epidemiological level, the underlying mechanism linking these two common disorders is not as clearly understood. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individuals possess a maximum capacity for adipose expansion which is determined by both genetic and environmental factors. Once the adipose tissue expansion limit is reached, adipose tissue ceases to store energy efficiently and lipids begin to accumulate in other tissues. Ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation. This article discusses the links between adipokines, inflammation, adipose tissue expandability and lipotoxicity. Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments.
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“Evidence suggests that dysfunctional AT promotes systemic low-grade inflammation, fat overflow, and, hence, ectopic lipid deposition, which further contributes to insulin resistance (Virtue and Vidal-Puig, 2010).”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“Excessive abdominal fat is associated with adipose tissue dysfunction, leading to systemic low-grade inflammation, fat overflow, ectopic lipid deposition, and reduced insulin sensitivity.”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“In fact, under excess caloric intake, WAT reaches its upper limit for further lipid storage ([157](#B157), [169](#B169)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [169]
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302
Diabetes Prevention Program Research Group (2009) · The Lancet · doi:10.1016/s0140-6736(09)61457-4 · Cited by 3,020
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
Kahn, S. E., Haffner, S. M., Heise, M. A., Herman, W. H., Holman, R. R., Jones, N. P., Kravitz, B. G., Lachin, J. M., O'Neill, M. C., Zinman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa066224 · Cited by 2,962
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Warnke (2018) · Research Publications (Maastricht University) · doi:10.26481/dis.20180316iw
PCB-associated steatohepatitis and the role of nuclear receptors.
Clair, H. B. (2017) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2867
Obesidad y síndrome metabólico
Vidal‐Puig, A., & Rodríguez, R. C. (2014) · Elsevier eBooks · doi:10.1016/b978-84-9022-595-0.00012-0 · Cited by 1
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Hogling, D. E. (2019) · Figshare
Capsaicinoids – a potential role for weight management
Whiting, S. (2026) · e-space (Manchester Metropolitan University) · doi:10.83056/mmu.32479050
Studies of the Systemic Inflammation in Psoriasis
Sigurdardottir, G. (2018) · Linköping University medical dissertations · doi:10.3384/diss.diva-151988
Extraordinary Claims, Extraordinary Proof
Nolen, T. G. (2019) · doi:10.1093/oso/9780190624965.003.0005
Brandão, C. F. C. E. C. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2019.tde-10042019-092726
Peters, K. M. (2019) · Scholarship@Western (Western University)
Anti-obesity effects of an aqueous extract of buchu
Huisamen, B., van Vuuren, M., & Pheiffer, C. (2019) · doi:10.4102/aosis.2019.bk84.04
Cambios en el peril proteómico de preadipocitos con diferentes condiciones metabólicas
Moreno‐Castellanos, N. (2019) · Salud UIS · doi:10.18273/revsal.v51n4-2019001
Identifying Potential biomarkers of insulin sensitivity and insulin resistance in obese patients
Al‐Sulaiti, H. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.122707627 · Cited by 1
Cephas, K. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
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Metabolic risk factors in mothers and metabolic profile of neonates
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Karbiener, M., & Scheideler, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-13689-9_9
Développement et adaptations du tissu adipeux pendant la prise de poids chez l’homme
Alligier, M., Disse, E., Vidal, H., & Laville, M. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0332-6_22
Weiss, L. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733689125.793562572
Karaman, Z. F., & Hatipoğlu, N. (2022) · The Journal of Pediatric Academy · doi:10.51271/jpea-2022-168
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Gonzalez Hernandez Manuel, A. (2020) · Research Publications (Maastricht University) · doi:10.26481/dis.20201027mgh
Nieuwenhuizen, A. G., & van Schothorst, E. M. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-1851-0
Dani, V., Bruni-Favier, S., Chignon‐Sicard, B., Loubat, A., Doglio, A., & Dani, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1733405/v1
Medina‐Gómez, G., Belgacem, A., Izquierdo‐Lahuerta, A., & Bitri, L. (2022) · Revista de la Sociedad Española de Cirugía de Obesidad y Metabólica y de la Sociedad Española para el Estudio de la Obesidad · doi:10.53435/funj.00635
Vesga-Jiménez, D. J. (2021) · Repositorio Institucional (Pontificia Universidad Javeriana) · doi:10.11144/javeriana.10554.53343
Redox Homeostasis and Nitro-Oxidative Stress in Obesity-Linked InflammationPreprint
Treiber, G., Samouda, H., Nobécourt, E., & Bottari, S. P. (2022) · Preprints.org · doi:10.20944/preprints202202.0180.v2
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Corrales, P., Martín-Taboada, M., Vila‐Bedmar, R., & Medina‐Gómez, G. (2022) · Revista de la Sociedad Española de Cirugía de Obesidad y Metabólica y de la Sociedad Española para el Estudio de la Obesidad · doi:10.53435/funj.00874
Hanninger, I., Levelt, E., Rayner, J. J., Rodgers, C., Neubauer, S., Grau, V., Rider, O. J., & Valkovič, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3034585/v1
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Kibodeaux, D., Savoie, J., Ravussin, É., Fitch, M. D., Hellerstein, M. K., & White, U. A. (2023) · Journal of Visualized Experiments · doi:10.3791/64883
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Smail, L., Hamlat, N., Berdja, S., Boumaza, S., Neggazi, S., Kacimi, G., Boudarene, L., & Bouguerra, S. A. (2024) · International Journal of Morphology · doi:10.4067/s0717-95022024000100197
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Mulard, E. D., Guibert, S., Mey, A., Lefevre, C., Chauvin, M., Pinteur, C., Monet, M., Godet, M., Madec, A., Morio, B., et al. (2024) · Nutrients · doi:10.3390/nu16060803 · Cited by 1
Ma, X., Liu, Y., Li, B., Zhao, H., Sun, Y., Han, H., Yu, W., Mu, W., & Liu, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-5869487/v1
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Islam, M. A., Gu, W., Song, Y., Xu, Y., & Xu, H. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0091
Huang, J. V., & Dehghan, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_9
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Madsen, J. D., Dam, T. V., Nambiar, J., Liang, C., Peltonen, A. R., Wernberg, C. W., Hansen, L. S. M., Rydbirk, R., Oussoren, L. M., Jakobsen, K. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.25.678284 · Cited by 1
Shaaban, R., Rimbert, A., Combot, Y., Ducheix, S., Chadeuf, G., Palard, M., Croyal, M., Hadjadj, S., Cariou, B., May, C. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692243
Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation
Negrin, K. A. (2014) · eScholarship@UMassChan · doi:10.13028/m24p4s
Mwabvu, T., Hamer, M., Slotow, R., & Barraclough, D. (2010) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.197298
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P. A., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13279512
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P. A., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13279509
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Salmón‐Gómez, L., Gómez‐Ambrosi, J., Frühbeck, G., & Catalán, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00346-0
Saha, P., Roy, M., & Arif, M. A. R. (2026) · TAJ Journal of Teachers Association · doi:10.70818/taj.v39i1.0418
Phadwal, K., Kurian, D., Haggarty, J. H., Migaud, H., Nicheva, V., Dick, J. R., Salamat, M. K. F., Whitfield, P. D., Matthew, C., Wade, N. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.13.711610
Lamin A/C in health, laminopathies, and familial partial lipodystrophy 2
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Yin, T.-T., Lin, H., Zhou, M., Li, J.-W., Mo, Q.-L., Wang, H.-J., Chen, J., Zhu, H., Li, Y.-T., Zheng, M., et al. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i13.115649
Tissu adipeux ectopique et pathologie cardiaque
Gaborit, B. (2013) · theses.fr (ABES) · doi:10.70675/950549dfzb0e2z4faaz9e53z9e9fd1812f11
Manidipa, M., Garg, S., Aggarwal, S., Chitkara, A., Garg, M., Acharya, P., & Garg, R. (2026) · National Journal of Medical Research · doi:10.55489/njmr.160220261270
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Lecoutre, S. (2017) · theses.fr (ABES) · doi:10.70675/65a35937ze6d1z436ezb142z7812e3f38007
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Nguyen‐Tu, M. (2013) · theses.fr (ABES) · doi:10.70675/7b9cc851z0ca7z4a23z87cbz7d788350ee0f
Impact de surnutritions expérimentales sur le tissu adipeux chez l’homme sain
Segrestin, B. (2019) · theses.fr (ABES) · doi:10.70675/95d575a7zf5b3z4111z891ez25e032d657ee
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Amosse, J. (2019) · theses.fr (ABES) · doi:10.70675/2d90fa73z378bz47bdza83cz809db70f24fb
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Guarnieri, G., Comeglio, P., Filippi, S., Cellai, I., Acciai, G., Bartolucci, G., Pini, A., Amedei, A., Silvestri, L., Garella, R., et al. (2026) · Endocrinology · doi:10.1210/endocr/bqag048
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Agbonifo, W. O., Chimezie, J., Awoleye, M. O., Francis, H. O., Oguntade, I. A., Aleruwa, S. O., Amoo, Z. A., & Adedeji, T. G. (2026) · The Journal of Nutritional Physiology · doi:10.1016/j.jnphys.2026.100031
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Xiong, N., Mi, L., Wang, X., Zhang, T., Zhang, G., Chen, Y., Mo, D., Peng, J., Yao, H., Li, S., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178942
González, S. A., Melchiori, R. E., Piñero, F., Schiavone, M. A., Brenzoni, M., García, G., Alarcón, P., Ferroni, F., Baratta, S., & Castellaro, C. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02105-3
Ramezankhani, A., Hadaegh, F., & Esmaeili, F. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-05692-1
Fang, Y., González-Nieves, S., Cifarelli, V., & Imoukhuede, P. I. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-026-00925-x
Levine, C. M., Caggiano, C., Anderson, T., Kelberman, M. A., Weinshenker, D., Lail, H. L., Wanders, D., Bangasser, D. A., Kanoski, S. E., & Parent, M. B. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06014-4
Ulanowska, M., Gjela, M., Nielsen, M. H., Askeland, A., Vestergaard, P., Frøkjær, J. B., Højlund, K., Mellergaard, M., & Handberg, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-57976-3
Hazaveh, M. M., Shojaei, S., Mousavi, A., Zooravar, D., Aghamohamadpour, S., Yousefifar, S., Talebpour, M., & Radkhah, H. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-02001-7
Acciai, G., Comeglio, P., Filippi, S., Cellai, I., Rapizzi, E., Mello, T., Holyer, I., Zetterberg, F. R., Galli, A., Vignozzi, L., et al. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1710592
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Yuan, X., Bao, C., & Feng, X. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1810408
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Minden, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-20529-2_13
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Lopes, A. R., Sousa, I., Nunes, F., Xará, S., Carvalho, M., Ferreira, W., Ferreira, N., Barros, A. S., Fontes‐Carvalho, R., Ribeiro, V. G., et al. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02195-z
Tang, J., Gupta, A., Wang, Z., Lee, M. K. H., & Barman, I. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c01501
Hanninger, I., Krafčík, A., Levelt, E., Rayner, J. J., Rodgers, C. T., Neubauer, S., Grau, V., Rider, O. J., & Valkovič, L. (2026) · NMR in Biomedicine · doi:10.1002/nbm.70400
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Metadata
- Authors
- Virtue, S., & Vidal-Puig, A.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Virtue, Sam
- ORCID
- Virtue, Sam
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 1801
- Issue
- 3
- Pages
- 338-349
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2035489548
- Semantic Scholar
- 470ac3b56b5b657fa79061f68dcdb8d8593fc4e8
- Cited by
- 1,013
- References
- 80
- Citations by year
- 2026: 58 · 2025: 65 · 2024: 49 · 2023: 46 · 2022: 68 · 2021: 62 · 2020: 52 · 2019: 68 · 2018: 77 · 2017: 75 · 2016: 64 · 2015: 66 · 2014: 68 · 2013: 76 · 2012: 69
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BB/E011950/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue expandability, lipotoxicity, metabolic syndrome, obesity, type 2 diabetes, allostasis, ectopic fat deposition, insulin resistance, adipokines, inflammation, apoptosis, diabetes treatment
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Diabetes Mellitus, Humans, Insulin Resistance, Liver, Models, Biological, Neovascularization, Pathologic, Adipocytes, Metabolic Syndrome, Lipid Metabolism, Insulin-Secreting Cells, Allostasis
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