The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Abstract
While the link between obesity and type 2 diabetes is clear on an epidemiological level, the underlying mechanism linking these two common disorders is not as clearly understood. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individuals possess a maximum capacity for adipose expansion which is determined by both genetic and environmental factors. Once the adipose tissue expansion limit is reached, adipose tissue ceases to store energy efficiently and lipids begin to accumulate in other tissues. Ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation. This article discusses the links between adipokines, inflammation, adipose tissue expandability and lipotoxicity. Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence suggests that dysfunctional AT promotes systemic low-grade inflammation, fat overflow, and, hence, ectopic lipid deposition, which further contributes to insulin resistance (Virtue and Vidal-Puig, 2010).”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“Excessive abdominal fat is associated with adipose tissue dysfunction, leading to systemic low-grade inflammation, fat overflow, ectopic lipid deposition, and reduced insulin sensitivity.”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“In fact, under excess caloric intake, WAT reaches its upper limit for further lipid storage ([157](#B157), [169](#B169)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [169]
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302
Diabetes Prevention Program Research Group (2009) · The Lancet · doi:10.1016/s0140-6736(09)61457-4 · Cited by 3,020
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
Kahn, S. E., Haffner, S. M., Heise, M. A., Herman, W. H., Holman, R. R., Jones, N. P., Kravitz, B. G., Lachin, J. M., O'Neill, M. C., Zinman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa066224 · Cited by 2,962
Cited by
Sorted by citations
Items 301–400 of 999
Guo, H., Bazuine, M., Jin, D., Huang, M. M., Cushman, S. W., & Chen, X. (2013) · Endocrinology · doi:10.1210/en.2013-1289 · Cited by 57
Adipose-derived stromal/stem cells from different adipose depots in obesity development
Silva, K. R., & Baptista, L. S. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i3.147 · Cited by 62
Suárez‐Cuenca, J. A., la Peña‐Sosa, G. D., la Vega-Moreno, K. D., Banderas-Lares, D. Z., Salamanca-García, M., Martínez-Hernández, J. E., Vera‐Gómez, E., Hernández‐Patricio, A., Zamora-Alemán, C. R., Domínguez-Pérez, G. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81289-2 · Cited by 61
Dietary fiber intake and non-alcoholic fatty liver disease: The mediating role of obesity
Zhu, Y., Hu, Y., Zhang, Y., Rao, S., Mo, Y., Zhang, H., Liang, S., Zhang, Z., & Yang, W. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1038435 · Cited by 53
Vasukova, E. A., Zaikova, E. K., Kalinina, O., Gorelova, I. V., Pyanova, I., Bogatyreva, E., Vasilieva, E. Y., Grineva, E. N., & Popova, P. (2023) · Biomedicines · doi:10.3390/biomedicines11102791 · Cited by 59
Bell-Anderson, K. S., Funnell, A. P. W., Williams, H., Jusoh, H. M., Scully, T., Lim, W. F., Burdach, J., Mak, K. S., Knights, A. J., Hoy, A. J., et al. (2013) · Diabetes · doi:10.2337/db12-1745 · Cited by 53
Martin, S., Fernandez-Rojo, M. A., Stanley, A. C., Bastiani, M., Okano, S., Nixon, S. J., Thomas, G. P., Stow, J. L., & Parton, R. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046242 · Cited by 54
Miana, M., Galán, M., Martínez‐Martínez, E., Varona, S., Jurado-López, R., Bausa-Miranda, B., Antequera-Pérez, A., Luaces, M., Martínez‐González, J., Rodríguez, C., et al. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.020107 · Cited by 54
Saultier, P., Auquier, P., Bertrand, Y., Vercasson, C., Oudin, C., Contet, A., Plantaz, D., Poiree, M., Ducassou, S., Kanold, J., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.148908 · Cited by 55
Cederquist, C., Lentucci, C., Calejman, C. M., Hayashi, V., Orofino, J., Guertin, D. A., Fried, S. K., Lee, M., Cardamone, M. D., & Perissi, V. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.007 · Cited by 53
Fatima, F., & Nawaz, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00545 · Cited by 51
de la Rosa, I. A., Escudero‐Contreras, A., Rodríguez‐Cuenca, S., Ruiz-Ponce, M., Jiménez, Y., Ruiz‐Limón, P., Pérez‐Sánchez, C., Ábalos‐Aguilera, M. C., Cecchi, I., Ortega, R., et al. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12743 · Cited by 55
Self-citationMartínez-García, C., Izquierdo, A., Velagapudi, V., Vivas, Y., Velasco, I., Campbell, M., Burling, K., Cava, F., Ros, M., Orešič, M., et al. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009266 · Cited by 52
Self-citationRole of nuclear receptor corepressor RIP140 in metabolic syndrome
Rosell, M., Jones, M. C., & Parker, M. G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.016 · Cited by 53
Arbonés-Mainar, J. M., Johnson, L. A., Torres-Pérez, E., Whitlock, A. E. G., Pérez‐Díaz, S., Raber, J., & Maeda, N. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.93 · Cited by 52
Sears, B., & Ricordi, C. (2012) · PubMed · Cited by 53
Fujimori, K., & Shibano, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf401154c · Cited by 52
Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
Wang, X., Xu, M., & Li, Y. (2022) · Nutrients · doi:10.3390/nu14153134 · Cited by 56
Kahn, H. S., Bullard, K. M., Barker, L. E., & Imperatore, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050428 · Cited by 51
Nadra, K., Médard, J., Mul, J. D., Han, G., Grès, S., Pende, M., METZGER, D., Chambon, P., Cuppen, E. P. J. G., Saulnier‐Blache, J. S., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00512-12 · Cited by 49
Schultz, N. S., Broholm, C., Gillberg, L., Mortensen, B., Jørgensen, S. W., Schultz, H. S., Scheele, C. C., Wojtaszewski, J. F. P., Pedersen, B. K., & Vaag, A. A. (2013) · Diabetes · doi:10.2337/db13-0621 · Cited by 51
Oudin, C., Berbis, J., Bertrand, Y., Vercasson, C., Thomas, F., Chastagner, P. B., Ducassou, S., Kanold, J., Tabone, M., Paillard, C., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.176123 · Cited by 51
New approaches targeting brown adipose tissue transplantation as a therapy in obesity
Soler‐Vázquez, M. C., Mera, P., Zagmutt, S., Serra, D., & Herrero, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.022 · Cited by 55
The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals
Wallis, N. J., & Raffan, E. (2020) · Genes · doi:10.3390/genes11111378 · Cited by 57
Siervo, M., Riley, H. L., Fernandez, B. O., Leckstrom, C. A., Martín, D., Mitchell, K., Levett, D. Z. H., Montgomery, H., Mythen, M. G., Grocott, M. P. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094915 · Cited by 50
Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?
Mansilla, E., Aquino, V. D., Zambón, D., Marin, G. H., Mártire, K., Roque, G., Ichim, T. E., Riordan, N. H., Patel, A. N., Sturla, F., et al. (2011) · Stem Cells International · doi:10.4061/2011/943216 · Cited by 53
Not all fats are created equal: adipose vs. ectopic fat, implication in cardiometabolic diseases
Gaggini, M., Saponaro, C., & Gastaldelli, A. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0006 · Cited by 51
Lacroix, D., Moutel, S., Coupaye, M., Huvenne, H., Faucher, P., Pelloux, V., Rouault, C., Bastard, J., Cagnard, N., Dubern, B., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3127 · Cited by 51
Virtue, S., Feldmann, H. M., Christian, M., Tan, C. Y., Masoodi, M., Dale, M., Lelliott, C., Burling, K., Campbell, M., Eguchi, N., et al. (2012) · Diabetes · doi:10.2337/db12-0015 · Cited by 50
Self-citationLongo, M., Spinelli, R., D’Esposito, V., Zatterale, F., Fiory, F., Nigro, C., Raciti, G. A., Miele, C., Formisano, P., Bèguinot, F., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.02.019 · Cited by 50
Kominiarek, M. A., Jungheim, E. S., Hoeger, K. M., Rogers, A. M., Kahan, S. I., & Kim, J. J. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.02.006 · Cited by 50
Brain Ceramide Metabolism in the Control of Energy Balance
Cruciani‐Guglielmacci, C., López, M., Campaña, M. B., & Stunff, H. L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00787 · Cited by 52
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
Pastel, E., McCulloch, L. J., Ward, R., Joshi, S., Gooding, K. M., Shore, A. C., & Kos, K. (2017) · Clinical Science · doi:10.1042/cs20160803 · Cited by 49
Obesity and Pregnancy, the Perfect Metabolic Storm
Corrales, P., Vidal-Puig, A., & Medina-Gómez, G. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00914-5 · Cited by 51
Self-citationGupta, N., Hallman, D., Dumuid, D., Vij, A., Rasmussen, C. L., Jørgensen, M. B., & Holtermann, A. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0419-8 · Cited by 48
Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?
Fall, T., Mendelson, M., & Speliotes, E. K. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.054 · Cited by 50
da Silva, I. V., & Soveral, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1057-0_15 · Cited by 47
Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences
Yau, T., Ng, N. Y. H., Cheung, L., & Ronald, C. W. (2017) · Hong Kong Medical Journal · doi:10.12809/hkmj176308 · Cited by 49
Gilardi, F., Winkler, C., Quignodon, L., Diserens, J.-G., Toffoli, B., Schiffrin, M., Sardella, C., Preitner, F., & Desvergne, B. (2019) · Metabolism · doi:10.1016/j.metabol.2019.03.003 · Cited by 48
Archer, A., Stolarczyk, É., Dória, M. L., Helguero, L. A., Domingues, R., Howard, J. K., Mode, A., Korach-André, M., & Gustafsson, J.-Å. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033977 · Cited by 47
Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins
da Silva, I. V., Rodrigues, J. S., Rebelo, I., Miranda, J. P., & Soveral, G. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2781-4 · Cited by 47
Virtue, S., Petkevicius, K., Moreno‐Navarrete, J. M., Jenkins, B., Hart, D., Dale, M., Koulman, A., Fernández‐Real, J. M., & Vidal‐Puig, A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.063 · Cited by 47
Self-citationXie, Y., Guo, R., Zhao, L., Guo, X., Sun, G., Sun, Z., Zheng, J., Sun, Y., & Zheng, L. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.07.003 · Cited by 47
On the Immunometabolic Role of NF-κB in Adipocytes
Griffin, M. J. (2022) · Immunometabolism · doi:10.20900/immunometab20220003 · Cited by 48
Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation
Karbiener, M., Glantschnig, C., Pisani, D. F., Laurencikiene, J., Dahlman, I. A., Herzig, S., Amri, E., & Scheideler, M. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.121 · Cited by 48
Nielsen, M. O., Kongsted, A. H., Thygesen, M. P., Strathe, A. B., Caddy, S., Quistorff, B., Jørgensen, W., Christensen, V. G., Husted, S., Chwalibog, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512004199 · Cited by 46
Dour, C. L., Wu, W., Béréziat, V., Capeau, J., Vigouroux, C., & Worman, H. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m071381 · Cited by 50
Firmin, F. F., Oger, F., Gheeraert, C., Dubois‐Chevalier, J., Vercoutter‐Edouart, A., Alzaïd, F., Mazuy, C., Dehondt, H., Alexandre, J., Derudas, B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14570-y · Cited by 49
Sandoval, V., Femenias, A., Martínez‐Garza, Ú., Sanz‐Lamora, H., Castagnini, J. M., Quifer‐Rada, P., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2019) · Antioxidants · doi:10.3390/antiox8090360 · Cited by 46
Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
Salvatore, T., Galiero, R., Caturano, A., Rinaldi, L., Criscuolo, L., Martino, A. D., Albanese, G., Vetrano, E., Catalini, C., Sardu, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010658 · Cited by 52
Shokouh, P., Jeppesen, P. B., Hermansen, K., Nørskov, N. P., Laustsen, C., Hamilton-Dutoit, S. J., Qi, H., Stødkilde‐Jørgensen, H., & Gregersen, S. (2017) · Nutrients · doi:10.3390/nu10010006 · Cited by 45
Translating aetiological insight into sustainable management of type 2 diabetes
Taylor, R., & Barnes, A. C. (2017) · Diabetologia · doi:10.1007/s00125-017-4504-z · Cited by 46
Virtue, S., Masoodi, M., de Weijer, B. A., van Eijk, M., Mok, C. Y. L., Eiden, M. J., Dale, M. M., Pirraco, A., Serlie, M. J. M., Griffin, J. L., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.34 · Cited by 44
Self-citationDankel, S. N., Degerud, E., Borkowski, K., Fjære, E., Midtbø, L. K., Haugen, C., Solsvik, M. H., Lavigne, A. M., Liaset, B., Sagen, J. V., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00188.2013 · Cited by 47
PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia
Jiang, M., Strand, D. W., Franco, O. E., Clark, P. E., & Hayward, S. W. (2011) · Differentiation · doi:10.1016/j.diff.2011.05.008 · Cited by 44
Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health
Brennan, K. M., Kroener, L. L., Chazenbalk, G. D., & Dumesic, D. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000661 · Cited by 44
Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences
Sulc, J., Winkler, T. W., Heid, I. M., & Kutalik, Z. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-1285-4 · Cited by 44
Brunner, J. S., Vogel, A., Lercher, A., Caldera, M., Korosec, A., Pühringer, M., Hofmann, M., Hajto, A., Kieler, M., Garrido, L. Q., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00311-5 · Cited by 45
Adeyanju, O. A., Badejogbin, O. C., Areola, E. D., Olaniyi, K. S., Dibia, C., Soetan, O. A., Oniyide, A. A., Michael, O. S., Olatunji, L. A., & Soladoye, A. O. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110994 · Cited by 44
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein, A. S., & Ravid, K. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24473 · Cited by 44
PPP2R5C couples hepatic glucose and lipid homeostasis
Cheng, Y.-S., Seibert, O., Klöting, N., Dietrich, A., Straßburger, K., Fernández-Veledo, S., Vendrell, J. J., Zorzano, A., Blüher, M., Herzig, S., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005561 · Cited by 43
The physiology of MASLD: molecular pathways between liver and adipose tissues
Lee, W., Kipp, Z. A., Bates, E. A., Pauss, S. N., Martinez, G. J., & Hinds, T. D. (2025) · Clinical Science · doi:10.1042/cs20257571 · Cited by 52
Alemany, M. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00027 · Cited by 45
Cero, C., Razzoli, M., Han, R., Sahu, B. S., Patricelli, J., Guo, Z., Zaidman, N. A., Miles, J. M., O’Grady, S. M., & Bartolomucci, A. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.005 · Cited by 43
The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence
Zafar, M. I., Zheng, J., Kong, W., Ye, X., Gou, L., Regmi, A., & Chen, L. (2017) · Bioscience Reports · doi:10.1042/bsr20171089 · Cited by 42
Tacherfiout, M., Petrov, P., Mattonai, M., Ribechini, E., Ribot, J., Bonet, M. L., & Khettal, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.106 · Cited by 45
Hou, Y., Liu, Z., Zuo, Z., Gao, T., Fu, J., Wang, H., Xu, Y., Liu, D., Yamamoto, M. P., Zhu, B., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.013 · Cited by 43
Vitamin A supplementation in early life affects later response to an obesogenic diet in rats
Granados, N., Amengual, J., Ribot, J., Mušinović, H., Ceresi, E., Lintig, J. V., Palou, A., & Bonet, M. L. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.190 · Cited by 40
McMorrow, A. M., Connaughton, R. M., Lithander, F. E., & Roche, H. M. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s002966511400158x · Cited by 43
Moreno‐Navarrete, J. M., Moreno, M., Ortega, F. J., Sabater, M., Xifra, G., Ricart, W., & Fernández‐Real, J. M. (2015) · Obesity · doi:10.1002/oby.21334 · Cited by 42
Obesity, Type 2 Diabetes, and the Metabolic Syndrome
Genser, L., Mariolo, J. R. C., Castagneto‐Gissey, L., Panagiotopoulos, S., & Rubino, F. (2016) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.03.013 · Cited by 47
The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths
Agrawal, M., Kern, P. A., & Nikolajczyk, B. S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0917-9 · Cited by 45
Natriuretic peptides in the control of lipid metabolism and insulin sensitivity
Verboven, K., Hansen, D., Jocken, J. W. E., & Blaak, E. E. (2017) · Obesity Reviews · doi:10.1111/obr.12598 · Cited by 45
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J., & Dumesic, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00021-4 · Cited by 41
FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity
Ye, M., Lu, W., Wang, X., Wang, C., Abbruzzese, J. L., Liang, G., Li, X., & Luo, Y. (2016) · Endocrinology · doi:10.1210/en.2016-1710 · Cited by 41
Brain JNK and metabolic disease
Nogueiras, R., & Sabio, G. (2020) · Diabetologia · doi:10.1007/s00125-020-05327-w · Cited by 42
Fano, M. D., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105511 · Cited by 44
Early Improvement of Postprandial Lipemia After Bariatric Surgery in Obese Type 2 Diabetic Patients
Griffo, E., Nosso, G., Lupoli, R., Cotugno, M., Saldalamacchia, G., Vitolo, G., Angrisani, L., Cutolo, P. P., Rivellese, A. A., & Capaldo, B. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1148-z · Cited by 41
Lu, C., Xie, T., Guo, X., Wu, D., Li, S., Li, X., Lu, Y., & Wang, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105969 · Cited by 45
Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease
Palacios‐Marin, I., Serra, D., Jiménez‐Chillarón, J. C., Herrero, L., & Todorčević, M. (2023) · Nutrients · doi:10.3390/nu15183968 · Cited by 47
Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning
Friedman, M. I., Sørensen, T. I. A., Taubes, G., Lund, J. T., & Ludwig, D. S. (2024) · Obesity Reviews · doi:10.1111/obr.13795 · Cited by 47
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Lecoutre, S., Rebière, C., Maqdasy, S., Lambert, M., Dussaud, S., Abatan, J. B., Dugail, I., Gautier, E. L., Clément, K., & Marcelin, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01071-y · Cited by 52
Carli, J. F. M., LeDuc, C. A., Zhang, Y., Stratigopoulos, G., & Leibel, R. L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m085555 · Cited by 41
Tuthill, B. F., Searcy, L. A., Yost, R. A., & Musselman, L. P. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000198 · Cited by 44
Gómez‐Pérez, Y., Capllonch-Amer, G., Gianotti, M., Lladó, I., & Proenza, A. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-15 · Cited by 42
Riis, S., Christensen, B., Nellemann, B., Møller, A. B., Husted, A. S., Pedersen, S. B., Schwartz, T. W., Jørgensen, J. O. L., & Jessen, N. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00989.2018 · Cited by 39
Effects of pregnancy on obesity-induced inflammation in a mouse model of fetal programming
Ingvorsen, C., Thysen, A. H., Fernandez‐Twinn, D. S., Nordby, P., Nielsen, K. F., Ozanne, S. E., Brix, S., & Hellgren, L. I. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.69 · Cited by 40
In vivo imaging and quantification of regional adiposity in zebrafish
Minchin, J. E. N., & Rawls, J. F. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2016.11.010 · Cited by 39
Taylor, R., & Barnes, A. C. (2018) · Diabetic Medicine · doi:10.1111/dme.13851 · Cited by 38
Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury
Kaur, S., Auger, C., & Jeschke, M. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.599576 · Cited by 39
Telomere length and metabolic syndrome traits: A Mendelian randomisation study
Loh, N. Y., Noordam, R., & Christodoulides, C. (2021) · Aging Cell · doi:10.1111/acel.13445 · Cited by 39
Patel, S., Haider, A., Álvarez-Guaita, A., Bidault, G., Moustafa, J. S. E.-S., Guiu‐Jurado, E., Tadross, J. A., Warner, J., Harrison, J., Virtue, S., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101589 · Cited by 42
Self-citationNotch intracellular domain overexpression in adipocytes confers lipodystrophy in mice
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O'Doherty, R. M., & Kensler, T. W. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.004 · Cited by 38
Cox‐York, K. A., Erickson, C. B., Pereira, R. I., Bessesen, D. H., & Pelt, R. E. V. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13011 · Cited by 37
Raciti, G. A., Spinelli, R., Desiderio, A., Longo, M., Parrillo, L., Nigro, C., D’Esposito, V., Mirra, P., Fiory, F., Pilone, V., et al. (2017) · Scientific Reports · doi:10.1038/srep43526 · Cited by 38
Bas-Prior, J. M. D., Guirro, M., Boqué, N., Cereto‐Massagué, A., Ras, R., Crescenti, A., Caimari, A., Canela-Canela, N., & Arola, L. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.284 · Cited by 41
CCN5/WISP2 and metabolic diseases
Grünberg, J. R., Elvin, J., Paul, A., Hedjazifar, S., Hammarstedt, A., & Smith, U. (2017) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0437-z · Cited by 41
Wolff, G., Taranko, A. E., Meln, I., Weinmann, J., Sijmonsma, T., Lerch, S., Heide, D., Billeter, A. T., Tews, D., Krunic, D., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.007 · Cited by 41
Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
Geberhiwot, T., Baig, S., Obringer, C., Girard, D., Dawson, C., Manolopoulos, K. N., Messaddeq, N., Lassen, P. B., Clément, K., Tomlinson, J., et al. (2020) · Diabetes · doi:10.2337/db20-0647 · Cited by 40
Cazac, G.-D., Lăcătușu, C.-M., Mihai, C., Grigorescu, E.-D., Onofriescu, A., & Mihai, B. M. (2022) · Life · doi:10.3390/life12081189 · Cited by 41
Metadata
- Authors
- Virtue, S., & Vidal-Puig, A.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Virtue, Sam
- ORCID
- Virtue, Sam
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 1801
- Issue
- 3
- Pages
- 338-349
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2035489548
- Semantic Scholar
- 470ac3b56b5b657fa79061f68dcdb8d8593fc4e8
- Cited by
- 1,013
- References
- 80
- Citations by year
- 2026: 58 · 2025: 65 · 2024: 49 · 2023: 46 · 2022: 68 · 2021: 62 · 2020: 52 · 2019: 68 · 2018: 77 · 2017: 75 · 2016: 64 · 2015: 66 · 2014: 68 · 2013: 76 · 2012: 69
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BB/E011950/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue expandability, lipotoxicity, metabolic syndrome, obesity, type 2 diabetes, allostasis, ectopic fat deposition, insulin resistance, adipokines, inflammation, apoptosis, diabetes treatment
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Diabetes Mellitus, Humans, Insulin Resistance, Liver, Models, Biological, Neovascularization, Pathologic, Adipocytes, Metabolic Syndrome, Lipid Metabolism, Insulin-Secreting Cells, Allostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
