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Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Abstract
While the link between obesity and type 2 diabetes is clear on an epidemiological level, the underlying mechanism linking these two common disorders is not as clearly understood. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individuals possess a maximum capacity for adipose expansion which is determined by both genetic and environmental factors. Once the adipose tissue expansion limit is reached, adipose tissue ceases to store energy efficiently and lipids begin to accumulate in other tissues. Ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation. This article discusses the links between adipokines, inflammation, adipose tissue expandability and lipotoxicity. Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments.
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“Evidence suggests that dysfunctional AT promotes systemic low-grade inflammation, fat overflow, and, hence, ectopic lipid deposition, which further contributes to insulin resistance (Virtue and Vidal-Puig, 2010).”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“Excessive abdominal fat is associated with adipose tissue dysfunction, leading to systemic low-grade inflammation, fat overflow, ectopic lipid deposition, and reduced insulin sensitivity.”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Virtue and Vidal-Puig, 2010
In the citing paper
“In fact, under excess caloric intake, WAT reaches its upper limit for further lipid storage ([157](#B157), [169](#B169)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [169]
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302
Diabetes Prevention Program Research Group (2009) · The Lancet · doi:10.1016/s0140-6736(09)61457-4 · Cited by 3,020
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
Kahn, S. E., Haffner, S. M., Heise, M. A., Herman, W. H., Holman, R. R., Jones, N. P., Kravitz, B. G., Lachin, J. M., O'Neill, M. C., Zinman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa066224 · Cited by 2,962
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Tuvdendorj, D., Munoz, A., Ruiz-Barros, V., Schwarz, J., Montalto, G., Chandalia, M., Sowers, L. C., Rizzo, M., Murphy, E. J., & Abate, N. I. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.06.024 · Cited by 6
Mazzaferro, E., Mújica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R. J. F., Vienberg, S. G., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-89823-2 · Cited by 8
Loss of CTRP10 results in female obesity with preserved metabolic health
Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.93373.3 · Cited by 8
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Sánchez-Oliver, A. J. (2018) · Current Research in Diabetes & Obesity Journal · doi:10.19080/crdoj.2018.07.555702 · Cited by 8
Nianogo, R. A., & Arah, O. A. (2019) · Epidemiology · doi:10.1097/ede.0000000000001062 · Cited by 6
Sanz‐Lamora, H., Marrero, P. F., Haro, D., & Relat, J. (2022) · Antioxidants · doi:10.3390/antiox11010120 · Cited by 6
Nakhaei, H., Nayebifar, S., & Fanaei, H. (2022) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2022-0003 · Cited by 6
Dos‐Santos, R. C., Ishioka, G., Cognuck, S. Q., Mantovani, M., Caliman, I. F., Elias, L. L. K., & Antunes‐Rodrigues, J. (2022) · Experimental Physiology · doi:10.1113/ep090513 · Cited by 6
Ramlugon, S., Levendal, R., & Frost, C. L. (2022) · Phytotherapy Research · doi:10.1002/ptr.7694 · Cited by 5
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Zaccardi, F., Pitocco, D., Martini, F., Caputo, S., Miele, L., Grieco, A., & Ghirlanda, G. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0382-5 · Cited by 6
Deleted in breast cancer 1 plays a functional role in adipocyte differentiation
Moreno‐Navarrete, J. M., Moreno, M., Vidal, M., Ortega, F. J., Serrano, M., Xifra, G., Ricart, W., & Fernández‐Real, J. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00286.2014 · Cited by 6
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Valencak, T. G., Spenlingwimmer, T., Nimphy, R., Reinisch, I., Hoffman, J. M., & Prokesch, A. (2020) · Metabolites · doi:10.3390/metabo10050176 · Cited by 6
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Torres, N., Torre-Villalvazo, I., & Tovar, A. R. (2019) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.18002843 · Cited by 6
Jorge, R., de Heredia, F. P., Gmez-Martnez, S., & Marcos, A. (2012) · InTech eBooks · doi:10.5772/25324 · Cited by 6
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Murphy, J., Dera, A. M., Morais, J. A., Tsoukas, M. A., Khor, N., Sazonova, T., Almeida, L. G., Cooke, A. B., Daskalopoulou, S. S., Tam, B. T., et al. (2024) · Obesity · doi:10.1002/oby.24059 · Cited by 6
Misceo, D., Mocciaro, G., D’Amore, S., & Vacca, M. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00871-3 · Cited by 6
Abdalla, M. M. I., & Soon, S. C. (2017) · Endocrine Regulations · doi:10.1515/enr-2017-0019 · Cited by 5
Ferguson, L. R., & Barnett, M. P. G. (2022) · Nutrients · doi:10.3390/nu14091743 · Cited by 5
Xu, D., Gong, Y., Xiang, X., Liu, Y., Mai, K., & Ai, Q. (2023) · Fish Physiology and Biochemistry · doi:10.1007/s10695-023-01208-2 · Cited by 5
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Camacho‐Morales, A., Segoviano-Ramírez, J. C., Sánchez‐García, A., la Rosa, J. D. J. H.-D., García‐Juárez, J., Hernandez-Puente, C. A., Calvo‐Anguiano, G., Maltos-Uro, S. R., Olguin, A., Gojon-Romanillos, G., et al. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0784-7 · Cited by 5
Walther, C. P., Ix, J. H., Biggs, M. L., Kizer, J. R., Navaneethan, S. D., Djoussé, L., & Mukamal, K. J. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.11.030 · Cited by 5
Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
Verschoor, P., Greig, F. H., Rochford, J. J., Levate, G., Delibegović, M., Thompson, D., Leeson-Payne, A. T. S., Dekeryte, R., Banks, R., Ramos, J. W., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86250-x · Cited by 4
Izquierdo, A., & Medina‐Gómez, G. (2012) · Diálisis y Trasplante · doi:10.1016/j.dialis.2011.11.001 · Cited by 5
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Pausová, Z. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00009-x · Cited by 5
Taxerås, S. D., Galán, M., Campderrós, L., Piquer‐Garcia, I., Pellitero, S., Martínez-Cáceres, E. M., Puig, R., Lucena, I., Tarascó, J., Moreno, P., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.381 · Cited by 5
Szablewski, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80248 · Cited by 5
Sakata, S., Ito, M., Mera, Y., Sasase, T., Yamamoto, H., Kakutani, M., & Ohta, T. (2014) · Journal of Diabetes Research · doi:10.1155/2014/803832 · Cited by 3
Hodson, L., & Fielding, B. A. (2013) · Cited by 5
Nirenjen, S., Singh, S. A., Begum, R. F., Arun, E., Vellapandian, C., & Narayanan, J. (2025) · Journal of Endocrinology · doi:10.1530/joe-24-0374 · Cited by 5
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Su, N., Zheng, J., Zhang, G., An, W., Chen, F., Xu, C., Xie, D., & Li, Y. (2025) · Aquaculture Nutrition · doi:10.1155/anu/1005455 · Cited by 4
Fernandes, C. J. D. C., Rodrigues, V. C. D. C., Pereira, G. J. D. S., de Melo, D. G., de Campos, T. D. P., Canciglieri, R. D. S., da Silva, R. A., da Silva, A. S. R., Pauli, J. R., Gross, A., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124105 · Cited by 4
Li, N., Zhu, Z., Wu, S., Gong, D., Day, R., Vijayakumar, V., Yu, X., Chen, Q., Feng, Y., Wang, Q., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.106560 · Cited by 5
Songkoomkrong, S., Nonkhwao, S., Saetan, J., Duangprom, S., Amonruttanapun, P., Janpan, P., Sobhon, P., & Kornthong, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114970 · Cited by 4
Sabarathinam, S. (2026) · Comprehensive physiology · doi:10.1002/cph4.70208 · Cited by 5
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Swanson, K., Bell, J., Hendrix, D. A., Jiang, D., Kutzler, M., Batty, B., Hanlon, M., & Bionaz, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302702 · Cited by 3
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Santoro, C., O’Toole, A., Finsel, P., Alvi, A., & Musselman, L. P. (2022) · Scientific Reports · doi:10.1038/s41598-022-16870-4 · Cited by 4
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Zhong, H., Yu, B., Zhao, F., Cui, H., You, L., Feng, D., & Lu, Y. (2023) · Medicine · doi:10.1097/md.0000000000036388 · Cited by 4
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Yang, D. B., Gao, L., Liu, X., Xu, Y. C., Hambly, C., Wang, D. H., & Speakman, J. R. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101724 · Cited by 4
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Manzoni, G., Oltolini, A., Perra, S., Muraca, E., Ciardullo, S., Pizzi, M., Castoldi, G., Lattuada, G., Pizzi, P., & Perseghin, G. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s228229 · Cited by 4
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Weinstein, E. J., Carbonari, D. M., Newcomb, C. W., Torgersen, J., Smith, S. M., Brecker, K. L., Liu, X. S., Kostman, J. R., Trooskin, S. B., Hubbard, R. A., et al. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaf102 · Cited by 3
Agha, A., Afandi, B. O., Alhammadi, W. I., Almaskari, H. J. M., Alshamsi, A., Saleem, M., & Kaabi, J. A. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100656 · Cited by 3
Sormani, L. E., Palacio, T. L. N., & Corrêa, C. R. (2025) · Nutrire · doi:10.1186/s41110-025-00394-8 · Cited by 3
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Reyes‐Farias, M., González, L., Ibeas, K., Cereijo, R., Taxerås, S. D., Pellitero, S., Martínez-Cáceres, E. M., Tarascó, J., Moreno, P., Malagón, P., et al. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1130 · Cited by 3
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Acosta, F. M., Sánchez‐Delgado, G., Martínez‐Téllez, B., Osuna‐Prieto, F. J., Méndez-Gutiérrez, A., Aguilera, C. M., Gil, Á., Elvira, J. M. L., & Ruiz, J. R. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0130 · Cited by 3
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Chu, J. J., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00003-5 · Cited by 5
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Metadata
- Authors
- Virtue, S., & Vidal-Puig, A.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Virtue, Sam
- ORCID
- Virtue, Sam
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 1801
- Issue
- 3
- Pages
- 338-349
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2035489548
- Semantic Scholar
- 470ac3b56b5b657fa79061f68dcdb8d8593fc4e8
- Cited by
- 1,013
- References
- 80
- Citations by year
- 2026: 58 · 2025: 65 · 2024: 49 · 2023: 46 · 2022: 68 · 2021: 62 · 2020: 52 · 2019: 68 · 2018: 77 · 2017: 75 · 2016: 64 · 2015: 66 · 2014: 68 · 2013: 76 · 2012: 69
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BB/E011950/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue expandability, lipotoxicity, metabolic syndrome, obesity, type 2 diabetes, allostasis, ectopic fat deposition, insulin resistance, adipokines, inflammation, apoptosis, diabetes treatment
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Diabetes Mellitus, Humans, Insulin Resistance, Liver, Models, Biological, Neovascularization, Pathologic, Adipocytes, Metabolic Syndrome, Lipid Metabolism, Insulin-Secreting Cells, Allostasis
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