Cited by 139Autophagy in Disease and TherapyLipid metabolism and biosynthesisAdipose Tissue and Metabolism

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Autophagy: Emerging roles in lipid homeostasis and metabolic control

Christian, Patricia, Sacco, Jennifer, Adeli, Khosrow·2013·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2012.12.009

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Abstract

Current evidence implicates autophagy in the regulation of lipid stores within the two main organs involved in maintaining lipid homeostasis, the liver and adipose tissue. Critical to this role in hepatocytes is the breakdown of cytoplasmic lipid droplets, a process referred to as lipophagy. Conversely, autophagy is required for adipocyte differentiation and the concurrent accumulation of lipid droplets. Autophagy also affects lipid metabolism through contributions to lipoprotein assembly. A number of reports have now implicated autophagy in the degradation of apolipoprotein B, the main structural protein of very-low-density-lipoprotein. Aberrant autophagy may also be involved in conditions of deregulated lipid homeostasis in metabolic disorders such as the metabolic syndrome. First, insulin signalling and autophagy activity appear to diverge in a mechanism of reciprocal regulation, suggesting a role for autophagy in insulin resistance. Secondly, upregulation of autophagy may lead to conversion of white adipose tissue into brown adipose tissue, thus regulating energy expenditure and obesity. Thirdly, upregulation of autophagy in hepatocytes could increase breakdown of lipid stores controlling triglyceride homeostasis and fatty liver. Taken together, autophagy appears to play a very complex role in lipid homeostasis, affecting lipid stores differently depending on the tissue, as well as contributing to pathways of lipoprotein metabolism.

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Authors: Christian, P., Sacco, J., & Adeli, K.
Affiliations: University of Toronto (CA)
Corresponding author: Adeli, Khosrow
ORCID: Adeli, Khosrow
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2013-04
Volume: 1831
Issue: 4
Pages: 819-824
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2012.12.009
OpenAlex: W2021662620
Cited by: 139
References: 66
Citations by year: 2026: 2 · 2025: 6 · 2024: 12 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 16 · 2017: 9 · 2016: 12 · 2015: 18 · 2014: 17 · 2013: 9
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: autophagy, lipid homeostasis, lipophagy, lipid droplets, adipogenesis, lipoprotein assembly, VLDL, metabolic syndrome, insulin resistance, insulin signaling, brown adipose tissue, white adipose tissue, energy expenditure, obesity, hepatic steatosis, triglyceride homeostasis, hepatocytes, adipose tissue
MeSH terms: Animals, Apolipoproteins B, Autophagy, Humans, Lipoproteins, Adipocytes, Hepatocytes, Lipid Metabolism

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Autophagy: Emerging roles in lipid homeostasis and metabolic control

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