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Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

D'Amore, Simona, Vacca, Michele, Cariello, Marica, Graziano, Giusi, D'Orazio, Andria, Salvia, Roberto, Sasso, Rosa Cinzia, Sabbà, Carlo +2 more·2016·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2016.07.003
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Abstract

Extra virgin olive oil (EVOO) consumption has been associated with reduced cardiovascular risk but molecular mechanisms underlying its beneficial effects are not fully understood. Here we aimed to identify genes and miRNAs expression changes mediated by acute high- and low-polyphenols EVOO intake. Pre- and post-challenge gene and miRNAs expression analysis was performed on the peripheral blood mononuclear cells (PBMCs) of 12 healthy subjects and 12 patients with metabolic syndrome (MS) by using microarray and RT-qPCR. In healthy subjects, acute intake of EVOO rich in polyphenols was able to ameliorate glycaemia and insulin sensitivity, and to modulate the transcription of genes and miRNAs involved in metabolism, inflammation and cancer, switching PBMCs to a less deleterious inflammatory phenotype; weaker effects were observed in patients with MS as well as in healthy subjects following low-polyphenol EVOO challenge. Concluding, our study shows that acute high-polyphenols EVOO intake is able to modify the transcriptome of PBMCs through the modulation of different pathways associated with the pathophysiology of cardio-metabolic disease and cancer. These beneficial effects are maximized in healthy subjects, and by the use of EVOO cultivars rich in polyphenols. Nutrigenomic changes induced by EVOO thus legitimate the well-known beneficial effects of EVOO in promoting human health and, potentially, preventing the onset of cardiovascular disease and cancer.

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Crossref · 10.1016/j.bbalip.2016.07.003

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  • In vitro and in vivo studies have described dramatic changes in transcription of genes and microRNAs involved in the pathophysiology of cardiometabolic diseases and cancer following EVOO interventions.

    “As concerns possible mechanisms for a chemopreventive role of the MedDiet, several in vitro [174] and in vivo [175,176] studies have described dramatic changes in the transcription of genes and micro-RNAs involved in the pathophysiology of cardiometabolic diseases and cancer, following EVOO interventions.”

    From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [175]

  • CREBBP was downregulated following acute EVOO intervention in both normal weight and obese individuals.

    “Interestingly, the cAMP response element binding protein (CREB) binding protein gene (CREBBP) was downregulated following acute EVOO intervention, in both normal weight and obese individuals [175].”

    From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [175]

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Authors
D'Amore, S., Vacca, M., Cariello, M., Graziano, G., D'Orazio, A., Salvia, R., Sasso, R. C., Sabbà, C., Palasciano, G., & Moschetta, A.
Affiliations
  • University of Bari Aldo Moro (IT)
  • Istituto Tumori Bari (IT)
Corresponding author
Moschetta, Antonio
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2016-11
Volume
1861
Issue
11
Pages
1671-1680
ISSN
1388-1981 (ISSN-L)
DOI
10.1016/j.bbalip.2016.07.003
OpenAlex
W2464528610
Cited by
107
References
54
Citations by year
2026: 2 · 2025: 4 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 20 · 2019: 12 · 2018: 12 · 2017: 6 · 2016: 2
FWCI
4.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders
  • Apulian Region - Italy (CIP PS_101)
  • Programma Operativo Nazionale (PON01_01958 PIVOLIO)
  • Italian Association for Cancer Research (IG 10410)
  • Fondazione Umberto Veronesi (fellowship)
  • Medical Research Council (MC_PC_13030)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
extra virgin olive oil, metabolic syndrome, polyphenols, peripheral blood mononuclear cells, microRNA expression, gene expression, nutrigenomics, insulin sensitivity, glycemia, inflammation, cardiovascular disease prevention, cancer prevention
MeSH terms
Olive Oil, Adult, Feeding Behavior, Female, Gene Expression Regulation, Humans, Leukocytes, Mononuclear, Male, Reproducibility of Results, Gene Expression Profiling, Metabolic Syndrome, MicroRNAs, Polyphenols, Real-Time Polymerase Chain Reaction, Healthy Volunteers

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