The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Regulation of MAP kinases by MAP kinase phosphatases
Open accessAbstract
MAP kinase phosphatases (MKPs) catalyze dephosphorylation of activated MAP kinase (MAPK) molecules and deactivate them. Therefore, MKPs play an important role in determining the magnitude and duration of MAPK activities. MKPs constitute a structurally distinct family of dual-specificity phosphatases. The MKP family members share the sequence homology and the preference for MAPK molecules, but they are different in substrate specificity among MAPK molecules, tissue distribution, subcellular localization and inducibility by extracellular stimuli. Our understanding of their protein structure, substrate recognition mechanisms, and regulatory mechanisms of the enzymatic activity has greatly increased over the past few years. Furthermore, although there are a number of MKPs, that have similar substrate specificities, non-redundant roles of MKPs have begun to be identified. Here we focus on recent findings regarding regulation and function of the MKP family members as physiological regulators of MAPK signaling.
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MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
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Cited by
ERK1/2 MAP kinases: Structure, function, and regulation
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ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence
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Understanding MAPK Signaling Pathways in Apoptosis
Yue, J., & López, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072346 · Cited by 1,245
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
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Metadata
- Authors
- Kondoh, K., & Nishida, E.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 1773
- Issue
- 8
- Pages
- 1227-1237
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2161696777
- Cited by
- 268
- References
- 11
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kondoh, K., & Nishida, E. (2007). Regulation of MAP kinases by MAP kinase phosphatases. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2006.12.002
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