Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
Open accessAbstract
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases that play the major role in signal transduction from the cell surface to the nucleus. MAPKs, which consist of growth factor-regulated extracellular signal-related kinases (ERKs), and the stress-activated MAPKs, c-jun NH 2 -terminal kinases (JNKs) and p38 MAPKs, are part of a three-kinase signaling module composed of the MAPK, an MAPK kinase (MAP2K) and an MAPK kinase (MAP3K). MAP3Ks phosphorylate MAP2Ks, which in turn activate MAPKs. MAPK phosphatases (MKPs), which recognize the TXY amino acid motif present in MAPKs, dephosphorylate and deactivate MAPKs. MAPK pathways are known to be influenced not only by receptor ligand interactions, but also by different stressors placed on the cell. One type of stress that induces potential activation of MAPK pathways is the oxidative stress caused by reactive oxygen species (ROS). Generally, increased ROS production in a cell leads to the activation of ERKs, JNKs, or p38 MAPKs, but the mechanisms by which ROS can activate these kinases are unclear. Oxidative modifications of MAPK signaling proteins and inactivation and/or degradation of MKPs may provide the plausible mechanisms for activation of MAPK pathways by ROS, which will be reviewed in this paper.
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ROS can oxidize MAPK and hyper-activate MAPK/ERK pro-proliferative signaling.
“ROS can oxidize MAPK and hyper-activate MAPK/ERK pro-proliferative signaling (Son et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Son et al. 2011
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- Authors
- Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O.
- Affiliations
- Wonkwang University (KR)
- Wonkwang University Hospital (KR)
- University of Ulsan (KR)
- Corresponding author
- Pae, Hyun-Ock
- Venue
- Journal of Signal Transduction
- Publisher
- Wiley
- Published
- 2011-02-06
- Volume
- 2011
- Pages
- 1-6
- ISSN
- 2090-1739 (ISSN-L)
- 2090-1747
- PMC
- PMC3100083
- OpenAlex
- W1995986855
- Cited by
- 1,219
- References
- 38
- Citations by year
- 2026: 85 · 2025: 109 · 2024: 114 · 2023: 107 · 2022: 115 · 2021: 117 · 2020: 100 · 2019: 82 · 2018: 86 · 2017: 93 · 2016: 58 · 2015: 62 · 2014: 37 · 2013: 36 · 2012: 13
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Signal Transduction (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Daiichi Sankyo Korea Co., Ltd.
- Astellas Pharma
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- mitogen-activated protein kinase, reactive oxygen species, oxidative stress, MAPK activation, ERK, JNK, p38 MAPK, MAPK phosphatase, MAP3K, MEK, MAPK signaling
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