The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
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Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells release toxic cytokines and free radicals, resulting in secondary neuronal damage. In this study, we show that the endocannabinoid system is highly activated during CNS inflammation and that the endocannabinoid anandamide (AEA) protects neurons from inflammatory damage by CB(1/2) receptor-mediated rapid induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) in microglial cells associated with histone H3 phoshorylation of the mkp-1 gene sequence. As a result, AEA-induced rapid MKP-1 expression switches off MAPK signal transduction in microglial cells activated by stimulation of pattern recognition receptors. The release of AEA in injured CNS tissue might therefore represent a new mechanism of neuro-immune communication during CNS injury, which controls and limits immune response after primary CNS damage.
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AEA inhibits microglial nitric oxide synthesis through the mitogen-activated protein kinase pathway.
“AEA inhibits microglial nitric oxide (NO) synthesis through the mitogen-activated protein kinase pathway (Eljaschewitsch et al, 2006) and inhibits tumor necrosis factor α (TNF-α) activation of the transcription nuclear factor kappa B (Sancho et al, 2003).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Eljaschewitsch et al, 2006
Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913 · see citing works
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
Galiègue, S., Mary, S., Marchand, J., Dussossoy, D., Carrière, D., Carayon, P., Bouaboula, M., Shire, D. J., Fur, G. L., & Casellas, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20780.x · Cited by 1,751 · see citing works
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
Marzo, V. D., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., & Piomelli, D. (1994) · Nature · doi:10.1038/372686a0 · Cited by 1,585 · see citing works
Characterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300 · see citing works
Endocannabinoid Signaling in the Brain
Wilson, R. I., & Nicoll, R. A. (2002) · Science · doi:10.1126/science.1063545 · Cited by 1,260 · see citing works
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutiérrez, S. O., van der Stelt, M., et al. (2003) · Science · doi:10.1126/science.1088208 · Cited by 1,208 · see citing works
Kreitzer, A. C., & Regehr, W. G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00246-x · Cited by 873 · see citing works
Inflammation and glial responses in ischemic brain lesions
Stoll, G. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00034-3 · Cited by 794 · see citing works
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M. A., & Piomelli, D. (1999) · Nature Neuroscience · doi:10.1038/7268 · Cited by 771 · see citing works
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Panikashvili, D., Simeonidou, C., Ben‐Shabat, S., Hanuš, L., Breuer, A., Mechoulam, R., & Shohami, E. (2001) · Nature · doi:10.1038/35097089 · Cited by 752 · see citing works
Cannabinoid-based drugs as anti-inflammatory therapeutics
Klein, T. W. (2005) · Nature Reviews Immunology · doi:10.1038/nri1602 · Cited by 728 · see citing works
Galve‐Roperh, I., Sánchez, C., Cortés, M. L., del Pulgar, T. G., Izquierdo, M., & Guzmán, M. (2000) · Nature Medicine · doi:10.1038/73171 · Cited by 684 · see citing works
Modulation of transmitter release via presynaptic cannabinoid receptors
Schlicker, E., & Kathmann, M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01805-8 · Cited by 671 · see citing works
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
Walter, L. M., Franklin, A. A., Witting, A., Wade, C. B., Xie, Y., Kunos, G., Mackie, K., & Stella, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01398.2003 · Cited by 666 · see citing works
Self-citationNew concepts in the immunopathogenesis of multiple sclerosis
Hemmer, B., Archelos, J., & Hartung, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn784 · Cited by 605 · see citing works
Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
Alger, B. E. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00080-1 · Cited by 599 · see citing works
Brewer, G. J. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420510 · Cited by 546 · see citing works
Bouaboula, M., Poinot‐Chazel, C., Bourrié, B., Canat, X., Calandra, B., Rinaldi, M. L., Fur, G. L., & Casellas, P. (1995) · Biochemical Journal · doi:10.1042/bj3120637 · Cited by 542 · see citing works
Llano, I., Leresche, N., & Marty, A. (1991) · Neuron · doi:10.1016/0896-6273(91)90059-9 · Cited by 494 · see citing works
Pain modulation by release of the endogenous cannabinoid anandamide
Walker, J. M., Huang, S. M., Strangman, N. M., Tsou, K., & Sañudo-Peña, M. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12198 · Cited by 486 · see citing works
An immortalized cell line expresses properties of activated microglial cells
Bocchini, V., Mazzolla, R., Barluzzi, R., Blasi, E., Sick, P., & Kettenmann, H. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310405 · Cited by 364 · see citing works
Carrier, E. J., Kearn, C. S., Barkmeier, A. J., Breese, N. M., Yang, W., Nithipatikom, K., Pfister, S. L., Campbell, W. B., & Hillard, C. J. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.999 · Cited by 336 · see citing works
Functional CB1 cannabinoid receptors in human vascular endothelial cells
Liu, J., Gao, B., Mirshahi, F., Sanyal, A. J., Khanolkar, A. D., Makriyannis, A., & Kunos, G. (2000) · Biochemical Journal · doi:10.1042/bj3460835 · Cited by 335 · see citing works
Cannabinoids and neuroinflammation
Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 334 · see citing works
Regulation of Extracellular Signal-Regulated Kinase by Cannabinoids in Hippocampus
Derkinderen, P., Valjent, E., Toutant, M., Corvol, J., Enslen, H., Ledent, C. A., Trzăskos, J. M., Caboche, J., & Girault, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02371.2003 · Cited by 331 · see citing works
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
Arévalo‐Martín, Á., Vela, J. M., Molina‐Holgado, E., Borrell, J. I., & Guaza, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02511.2003 · Cited by 314 · see citing works
Behavioral Effects of Cannabinoid Agents in Animals
Chaperon, F., & Thiébot, M.-H. (1999) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v13.i3.20 · Cited by 311 · see citing works
Marzo, V. D., Bisogno, T., PETROCELLIS, L. D., Melck, D. J., Orlando, P., Wagner, J. A., & Kunos, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00631.x · Cited by 296 · see citing works
Signaling Pathway Associated with Stimulation of CB2 Peripheral Cannabinoid Receptor
Bouaboula, M., Poinot‐Chazel, C., Marchand, J., Canat, X., Bourrié, B., Rinaldi, M. L., Calandra, B., Fur, G. L., & Casellas, P. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0704p.x · Cited by 285 · see citing works
Mabuchi, T., Kitagawa, K., Ohtsuki, T., Kuwabara, K., Yagita, Y., Yanagihara, T., Hori, M., & Matsumoto, M. (2000) · Stroke · doi:10.1161/01.str.31.7.1735 · Cited by 280 · see citing works
Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide
Facchinetti, F., Giudice, E. D., Furegato, S., Passarotto, M., & Leon, A. (2002) · Glia · doi:10.1002/glia.10177 · Cited by 275 · see citing works
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
del Pulgar, T. G., Velasco, G., & Guzmán, M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470369 · Cited by 260 · see citing works
Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705304 · Cited by 244 · see citing works
Liu, J., Bátkai, S., Pacher, P., Harvey-White, J. D., Wagner, J. A., Cravatt, B. F., Gao, B., & Kunos, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306062200 · Cited by 234 · see citing works
Franklin, A. A., Parmentier‐Batteur, S., Walter, L. M., Greenberg, D. A., & Stella, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07767.2003 · Cited by 230 · see citing works
Waksman, Y., Olson, J. M., Carlisle, S. J., & Cabral, G. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38093-0 · Cited by 223 · see citing works
Control of the cell survival/death decision by cannabinoids
Guzmán, M., Sánchez, C., & Galve‐Roperh, I. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000177 · Cited by 223 · see citing works
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
Hansen, H. H., Schmid, P. C., Bittigau, P., Lastres‐Becker, I., Berrendero, F., Manzanares, J., Ikonomidou, C., Schmid, H. H. O., Fernández‐Ruiz, J. J., & Hansen, H. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00542.x · Cited by 215 · see citing works
Safety, tolerability, and efficacy of orally administered cannabinoids in MS
Killestein, J., Hoogervorst, E. L. J., Reif, M., Kalkers, N. F., Loenen, A. C. V., Staats, P. G. M., Gorter, R. W., Uitdehaag, B. M. J., & Polman, C. H. (2002) · Neurology · doi:10.1212/wnl.58.9.1404 · Cited by 209 · see citing works
The CB1 Cannabinoid Receptor Is Coupled to the Activation of c-Jun N-Terminal Kinase
Rueda, D., Galve‐Roperh, I., Haro, A., & Guzmán, M. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.4.814 · Cited by 200 · see citing works
Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling
Piomelli, D., & Greengard, P. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90182-8 · Cited by 194 · see citing works
F‐ATPase: specific observation of the rotating c subunit oligomer of EFoEF1
Pänke, O., Gumbiowski, K., Junge, W., & Engelbrecht, S. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01436-8 · Cited by 189 · see citing works
P2X 7 receptors control 2-arachidonoylglycerol production by microglial cells
Witting, A., Walter, L. M., Wacker, J. L., Möller, T., & Stella, N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306707101 · Cited by 187 · see citing works
Self-citationSafety, tolerability, and efficacy of orally administered cannabinoids in MS
Russo, E. B. (2003) · Neurology · doi:10.1212/wnl.60.4.729-a · Cited by 184 · see citing works
Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide
Derkinderen, P., Toutant, M., Burgaya, F., Bert, M. L., Siciliano, J. C., de Franciscis, V., Gelman, M., & Girault, J. (1996) · Science · doi:10.1126/science.273.5282.1719 · Cited by 180 · see citing works
Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1
Ullrich, O., Diestel, A., Eyüpoglu, I. Y., & Nitsch, R. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-1035 · Cited by 175 · see citing works
Self-citationStimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells
Bouaboula, M., Bourrié, B., Rinaldi, M. L., Shire, D. J., Fur, G. L., & Casellas, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.13973 · Cited by 175 · see citing works
Li, J., Gorospe, M., Hutter, D., Barnes, J., Keyse, S. M., & Liu, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.8213-8224.2001 · Cited by 173 · see citing works
The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide
Wartmann, M., Campbell, D., Subramanian, A., BURSTEIN, S. H., & Davis, R. J. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00027-7 · Cited by 173 · see citing works
Berdyshev, E. V., Boichot, E., Germain, N., Allain, N., Anger, J.-P., & Lagente, V. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01007-8 · Cited by 167 · see citing works
Gallily, R., Breuer, A., & Mechoulam, R. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00653-1 · Cited by 163 · see citing works
Diestel, A., Aktas, O., Hackel, D., Häke, I., Meier, S., Raine, C. S., Nitsch, R., Zipp, F., & Ullrich, O. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030975 · Cited by 155 · see citing works
Self-citationAnandamide induces apoptosis of PC‐12 cells: involvement of superoxide and caspase‐3
Sarker, K. P., Obara, S., Nakata, M., Kitajima, I., & Maruyama, I. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01425-3 · Cited by 151 · see citing works
Laake, J. H., Haug, F. Š., Wieloch, T. W., & Ottersen, O. P. (1999) · Brain Research Protocols · doi:10.1016/s1385-299x(99)00021-5 · Cited by 150 · see citing works
Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds
Howlett, A. C. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90278-9 · Cited by 150 · see citing works
Induction of tolerance in rat cortical neurons: hypoxic preconditioning
Bruer, U., Weih, M., Исаев, Н. К., Meisel, A., Ruscher, K., Bergk, A., Trendelenburg, G., Wiegand, F., Victorov, I. V., & Dirnagl, U. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00954-x · Cited by 131 · see citing works
Endocannabinoids accumulate in spinal cord of SOD1G93A transgenic mice
Witting, A., Weydt, P., Hong, S. Y., Kliot, M., Möller, T., & Stella, N. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02544.x · Cited by 112 · see citing works
Self-citationFranklin, A., & Stella, N. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02074-0 · Cited by 111 · see citing works
Trettel, J., & Levine, E. S. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01037.2002 · Cited by 109 · see citing works
Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures
Adamchik, Y., Frantseva, M. V., Weisspapir, M., Carlen, P. L., & Perez Velazquez, J. L. (2000) · Brain Research Protocols · doi:10.1016/s1385-299x(00)00007-6 · Cited by 101 · see citing works
Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability
Jacobsson, S. O. P., Rongård, E., Stridh, M., Tiger, G., & Fowler, C. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00492-5 · Cited by 94 · see citing works
Guo, Y., Kang, B., & WILLIAMSON, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10362 · Cited by 83 · see citing works
Heppner, F. L., Skutella, T., Hailer, N. P., Haas, D., & Nitsch, R. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00379.x · Cited by 78 · see citing works
Self-citationEmerging properties of cannabinoid medicines in management of multiple sclerosis
Pryce, G., & Baker, D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.006 · Cited by 76 · see citing works
Cannabinoids and neuroprotection in CNS inflammatory disease
Jackson, S. J., Diemel, L. T., Pryce, G., & Baker, D. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.002 · Cited by 70 · see citing works
Shapiro, P. S., & Ahn, N. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1788 · Cited by 68 · see citing works
Stout Guards of the Central Nervous System
Mechoulam, R., & Lichtman, A. H. (2003) · Science · doi:10.1126/science.1091256 · Cited by 67 · see citing works
Biosynthesis and turnover of anandamide and other N‐acylethanolamines in peritoneal macrophages
Kuwae, T., Shiota, Y., Schmid, P. C., Krebsbach, R. J., & Schmid, H. H. O. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01226-0 · Cited by 41 · see citing works
Thompson, A. J., & Baker, D. (2002) · Neurology · doi:10.1212/wnl.58.9.1323 · Cited by 15 · see citing works
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Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529 · see citing works
Pathological and protective roles of glia in chronic pain
Milligan, E. D., & Watkins, L. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2533 · Cited by 1,404 · see citing works
MAPK phosphatases — regulating the immune response
Liu, Y., Shepherd, E. G., & Nelin, L. D. (2007) · Nature reviews. Immunology · doi:10.1038/nri2035 · Cited by 679 · see citing works
Neurotransmitter receptors on microglia
Pocock, J. M., & Kettenmann, H. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.07.007 · Cited by 650 · see citing works
The CB2 receptor and its role as a regulator of inflammation
Turcotte, C., Blanchet, M., Laviolette, M., & Flamand, N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2300-4 · Cited by 598 · see citing works
Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas
Stella, N. (2010) · Glia · doi:10.1002/glia.20983 · Cited by 529 · see citing works
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 482 · see citing works
A biosynthetic pathway for anandamide
Liu, J., Wang, L., Harvey-White, J. D., Osei‐Hyiaman, D., Razdan, R. J., Gong, Q., Chan, A. C., Zhou, Z., Huang, B. X., Kim, H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601832103 · Cited by 468 · see citing works
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity
Palazuelos, J., Aguado, T., Pazos, M. R., Julien, B., Carrasco, C., Resel, E., Sagredo, O., Benito, C., Romero, J., Azcoitia, I., et al. (2009) · Brain · doi:10.1093/brain/awp239 · Cited by 382 · see citing works
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
Munoz, L., & Ammit, A. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.010 · Cited by 370 · see citing works
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
Fernández‐Ruíz, J., Romero, J., Velasco, G., Tolón, R. M., Ramos, J. A., & Guzmán, M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.11.001 · Cited by 362 · see citing works
The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration
Ashton, J. C., & Glass, M. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866884 · Cited by 336 · see citing works
DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response
Lang, R., Hammer, M., & Mages, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7497 · Cited by 332 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Cannabinoid CB 2 receptors in human brain inflammation
Benito, C., Tolón, R. M., Pazos, M. R., Núñez, E., Castillo, A. I., & Romero, J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707505 · Cited by 293 · see citing works
Endocannabinoid signaling in microglial cells
Stella, N. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.037 · Cited by 271 · see citing works
Regulation of MAP kinases by MAP kinase phosphatases
Kondoh, K., & Nishida, E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.12.002 · Cited by 268 · see citing works
Benito, C., Romero, J. P., Tolón, R. M., Clemente, D., Docagne, F., Hillard, C. J., Guaza, C., & Romero, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4814-06.2007 · Cited by 256 · see citing works
Neuronal damage in brain inflammation
Aktas, O., Ullrich, O., Infante-Duarte, C., Nitsch, R., & Zipp, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.2.185 · Cited by 249 · see citing works
Turcotte, C., Chouinard, F., Lefebvre, J. S., & Flamand, N. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0115-021r · Cited by 249 · see citing works
Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation
Rom, S., & Persidsky, Y. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9445-9 · Cited by 240 · see citing works
Price, D. A., Martinez, A. A., Seillier, A., Koek, W., Acosta, Y. P. V., Fernández, E., Strong, R., Lutz, B., Marsicano, G., Roberts, J. L., et al. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06764.x · Cited by 231 · see citing works
Endocannabinoids and immune regulation☆
Pandey, R., Mousawy, K. M., Nagarkatti, M., & Nagarkatti, P. S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.019 · Cited by 232 · see citing works
Endocannabinoids drive the acquisition of an alternative phenotype in microglia
Mecha, M., Feliú, A., Carrillo-Salinas, F. J., Rueda-Zubiaurre, A., Ortega-Gutiérrez, S., de Sola, R. G., & Guaza, C. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.002 · Cited by 234 · see citing works
Non‐psychoactive CB 2 cannabinoid agonists stimulate neural progenitor proliferation
Palazuelos, J., Aguado, T., Egia, A., Mechoulam, R., Guzmán, M., & Galve‐Roperh, I. (2006) · The FASEB Journal · doi:10.1096/fj.06-6164fje · Cited by 222 · see citing works
An overview of the cannabinoid type 2 receptor system and its therapeutic potential
Bie, B., Wu, J., Foss, J. F., & Naguib, M. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000616 · Cited by 208 · see citing works
Centonze, D., Bari, M., Rossi, S., Prosperetti, C., Furlan, R., Fezza, F., De Chiara, V., Battistini, L., Bernardi, G., Bernardini, S., et al. (2007) · Brain · doi:10.1093/brain/awm160 · Cited by 207 · see citing works
Cyclooxygenase-2 in synaptic signaling
Yang, H., & Chen, C. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480144 · Cited by 195 · see citing works
Racz, I., Nadal, X., Alferink, J., Baños, J. E., Rehnelt, J., Martín, M., Pintado, B., Gutierrez-Adan, A., Sanguino, E., Manzanares, J., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3400-08.2008 · Cited by 195 · see citing works
Rosenberg, E. C., Patra, P. H., & Whalley, B. J. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.11.006 · Cited by 193 · see citing works
Microglia in central nervous system repair after injury
Jin, X., & Yamashita, T. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw009 · Cited by 191 · see citing works
Therapeutic approaches to inflammation in neurodegenerative disease
Klegeris, A., McGeer, E. G., & McGeer, P. L. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3280adc943 · Cited by 186 · see citing works
Correa, F., Hernangómez, M., Mestre, L., Loría, F., Spagnolo, A., Docagne, F., Marzo, V. D., & Guaza, C. (2009) · Glia · doi:10.1002/glia.20907 · Cited by 183 · see citing works
The endocannabinoid system in targeting inflammatory neurodegenerative diseases
Centonze, D., Finazzi‐Agrò, A., Bernardi, G., & Maccarrone, M. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.004 · Cited by 180 · see citing works
The endocannabinoid system as a target for the treatment of neurodegenerative disease
Scotter, E. L., Abood, M. E., & Glass, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00735.x · Cited by 181 · see citing works
Anti-inflammatory lipoxin A 4 is an endogenous allosteric enhancer of CB 1 cannabinoid receptor
Pamplona, F. A., Ferreira, J., de Lima, O. M., Duarte, F. S., Bento, A. F., Forner, S., Villarinho, J. G., Bellocchio, L., Wotjak, C. T., Lerner, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202906109 · Cited by 178 · see citing works
Munhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C., & Sapolsky, R. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0303-09.2010 · Cited by 169 · see citing works
Romero-Sandoval, A., Nutile-McMenemy, N., & DeLeo, J. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318167af74 · Cited by 168 · see citing works
The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking
Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado, T., Mechoulam, R., Benito, C., Romero, J., Silva, A., Guzmán, M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707960200 · Cited by 168 · see citing works
Bisogno, T., & Marzo, V. D. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710793361568 · Cited by 159 · see citing works
Romero-Sandoval, E. A., Horvath, R. J., Landry, R. P., & DeLeo, J. A. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-25 · Cited by 159 · see citing works
Microglia activation states and cannabinoid system: Therapeutic implications
Mecha, M., Carrillo-Salinas, F. J., Feliú, A., Mestre, L., & Guaza, C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.011 · Cited by 160 · see citing works
Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease
von Bernhardi, R., Cornejo, F., Parada, G. E., & Eugenín, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00426 · Cited by 149 · see citing works
Murikinati, S. R., Jüttler, E., Keinert, T., Ridder, D. A., Muhammad, S., Waibler, Z., Ledent, C. A., Zimmer, A., Kalinke, U., & Schwaninger, M. (2009) · The FASEB Journal · doi:10.1096/fj.09-141275 · Cited by 157 · see citing works
The endocannabinoid system in normal and pathological brain ageing
Bilkei‐Gorzó, A. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0388 · Cited by 157 · see citing works
Tronel, C., Largeau, B., Ribeiro, M. J., Guilloteau, D., Dupont, A.-C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040802 · Cited by 154 · see citing works
Kaminska, B., Mota, M., & Pizzi, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.026 · Cited by 153 · see citing works
Epigenetics Control Microglia Plasticity
Cheray, M., & Joseph, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00243 · Cited by 151 · see citing works
Anti-inflammatory mechanism of ginseng saponins in activated microglia
Park, J., Park, E., Kim, D., Jung, K., Jung, J.-S., Lee, E.-J., Hyun, J., Kang, J. L., & Kim, H.-S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.020 · Cited by 143 · see citing works
Neuroimmune interactions and pain: focus on glial-modulating targets.
Romero-Sandoval, E. A., Horvath, R. J., & DeLeo, J. A. (2008) · PubMed · Cited by 140 · see citing works
Chiurchiù, V., van der Stelt, M., Centonze, D., & Maccarrone, M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.007 · Cited by 140 · see citing works
Cannabinoids and autoimmune diseases: A systematic review
Katchan, V., David, P., & Shoenfeld, Y. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.008 · Cited by 143 · see citing works
Endocannabinoids in Synaptic Plasticity and Neuroprotection
Xu, J., & Chen, C. (2014) · The Neuroscientist · doi:10.1177/1073858414524632 · Cited by 138 · see citing works
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Wancket, L. M., Frazier, W. J., & Liu, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.11.017 · Cited by 134 · see citing works
Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation
Zhang, J., & Chen, C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800524200 · Cited by 135 · see citing works
Inhibition of COX‐2 expression by endocannabinoid 2‐arachidonoylglycerol is mediated via PPAR‐γ
Du, H., Chen, X., Zhang, J., & Chen, C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01444.x · Cited by 133 · see citing works
Interferon-γ Is a Critical Modulator of CB2Cannabinoid Receptor Signaling during Neuropathic Pain
Rácz, I., Nadal, X., Alferink, J., Baños, J.-E., Rehnelt, J., Martín, M., Pintado, B., Gutiérrez‐Adán, A., Sanguino, E., Bellora, N., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3402-08.2008 · Cited by 134 · see citing works
Bouchard, C., Pagé, J., Bédard, A., Tremblay, P., & Vallières, L. (2007) · Glia · doi:10.1002/glia.20506 · Cited by 132 · see citing works
Snider, N. T., Walker, V. J., & Hollenberg, P. F. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.001081 · Cited by 132 · see citing works
Hernangómez, M., Mestre, L., Correa, F., Loría, F., Mecha, M., Iñigo, P. M., Docagne, F., Williams, R. O., Borrell, J. I., & Guaza, C. (2012) · Glia · doi:10.1002/glia.22366 · Cited by 130 · see citing works
The Endocannabinoid System and Neurogenesis in Health and Disease
Galve‐Roperh, I., Aguado, T., Palazuelos, J., & Guzmán, M. (2007) · The Neuroscientist · doi:10.1177/1073858406296407 · Cited by 129 · see citing works
The endocannabinoid system is modulated in response to spinal cord injury in rats
García‐Ovejero, D., Arévalo‐Martín, Á., Petrosino, S., Docagne, F., Hagen, C., Bisogno, T., Watanabe, M., Guaza, C., Marzo, V. D., & Molina‐Holgado, E. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.015 · Cited by 125 · see citing works
Role of CB2 receptors in neuroprotective effects of cannabinoids
Fernández‐Ruíz, J., Pazos, M. R., Garcı́a-Arencibia, M., Sagredo, O., & Ramos, J. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.01.001 · Cited by 125 · see citing works
Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults
Chen, X., Zhang, J., & Chen, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.024 · Cited by 123 · see citing works
Effects of pro‐inflammatory cytokines on cannabinoid CB 1 and CB 2 receptors in immune cells
Jean-Gilles, L., Braitch, M. K., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., Robins, R. A., Tănăsescu, R., Tighe, P. J., Gran, B., et al. (2015) · Acta Physiologica · doi:10.1111/apha.12474 · Cited by 123 · see citing works
Pálóczi, J., Varga, Z. V., Hasko, G., & Pacher, P. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7144 · Cited by 121 · see citing works
Mechanisms of Control of Neuron Survival by the Endocannabinoid System
Galve‐Roperh, I., Aguado, T., Palazuelos, J., & Guzmán, M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208785740117 · Cited by 121 · see citing works
Neuroprotective agents: Cannabinoids
Sánchez, A., & Garcı́a-Merino, A. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.02.010 · Cited by 119 · see citing works
MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
Hollins, S. L., & Cairns, M. J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.005 · Cited by 117 · see citing works
Juknat, A., Pietr, M., Kozela, E., Rimmerman, N., Levy, R., Gao, F., Coppola, G., Geschwind, D. H., & Vogel, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061462 · Cited by 117 · see citing works
Taylor, D. M., Moser, R., Régulier, E., Breuillaud, L., Dixon, M. A., Beesen, A. A., Elliston, L., Santos, M. D. F. S., Kim, J., Jones, L., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4965-11.2013 · Cited by 116 · see citing works
Małek, N., Popiołek-Barczyk, K., Mika, J., Przewłocka, B., & Starowicz, K. (2015) · Neural Plasticity · doi:10.1155/2015/130639 · Cited by 114 · see citing works
Zhou, Y., Ling, E., & Dheen, S. T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04535.x · Cited by 115 · see citing works
Cannabinoids and Multiple Sclerosis
Pertwee, R. G. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0005-2 · Cited by 113 · see citing works
Concannon, R. M., Okine, B. N., Finn, D. P., & Dowd, E. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.007 · Cited by 112 · see citing works
Huo, Y., Rangarajan, P., Ling, E., & Dheen, S. T. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-49 · Cited by 112 · see citing works
Tabrizi, M. A., Baraldi, P. G., Borea, P. A., & Varani, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00411 · Cited by 110 · see citing works
Galve‐Roperh, I., Palazuelos, J., Aguado, T., & Guzmán, M. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0028-y · Cited by 110 · see citing works
Köfalvi, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3 · Cited by 110 · see citing works
Maccarrone, M., Battista, N., & Centonze, D. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.006 · Cited by 106 · see citing works
Persidsky, Y., Ho, W., Ramirez, S. H., Potula, R., Abood, M. E., Unterwald, E. M., & Tuma, R. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.001 · Cited by 106 · see citing works
The role of endocannabinoids in pain modulation
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works
Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
Marchalant, Y., Brothers, H. M., Norman, G. J., Karelina, K., DeVries, A. C., & Wenk, G. L. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.014 · Cited by 103 · see citing works
Tiwari, V., Guan, Y., & Raja, S. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.002 · Cited by 103 · see citing works
Microglial Activation in Alzheimers Disease
Schlachetzki, J. C. M., & Hüll, M. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147179 · Cited by 102 · see citing works
Cannabinoid signaling in health and disease
Lu, Y., & Anderson, H. D. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0346 · Cited by 102 · see citing works
Endocannabinoids in immune regulation and immunopathologies
Rahaman, O., & Ganguly, D. (2021) · Immunology · doi:10.1111/imm.13378 · Cited by 102 · see citing works
Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke
Zhang, M., Martin, B. R., Adler, M. W., Razdan, R. J., Kong, W., Ganea, D., & Tuma, R. F. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9148-4 · Cited by 101 · see citing works
Plasma endocannabinoid levels in multiple sclerosis
Jean-Gilles, L., Feng, S., Tench, C. R., Chapman, V., Kendall, D. A., Barrett, D. A., & Constantinescu, C. S. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.07.021 · Cited by 100 · see citing works
Wilkerson, J. L., Gentry, K. R., Dengler, E. C., Wallace, J. A., Kerwin, A. A., Armijo, L. M., Kuhn, M. N., Thakur, G. A., Makriyannis, A., & Milligan, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.02.015 · Cited by 99 · see citing works
Correa, F., Docagne, F., Mestre, L., Clemente, D., Hernangómez, M., Loría, F., & Guaza, C. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.014 · Cited by 98 · see citing works
The cannabinoid system and microglia in health and disease
Duffy, S. S., Hayes, J. P., Fiore, N. T., & Moalem‐Taylor, G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108555 · Cited by 96 · see citing works
Amtul, Z., Uhrig, M., Wang, L., Rozmahel, R. F., & Beyreuther, K. T. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.014 · Cited by 96 · see citing works
Lowin, T., Apitz, M., Anders, S., & Straub, R. H. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0845-5 · Cited by 94 · see citing works
Malcher‐Lopes, R., Franco, A. J., & Tasker, J. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.033 · Cited by 92 · see citing works
Sang, N., Zhang, J., & Chen, C. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04668.x · Cited by 91 · see citing works
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
Young, A. P., & Denovan‐Wright, E. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.806417 · Cited by 90 · see citing works
Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity?
Fowler, C. J., Rojo, M. L., & Rodríguez‐Gaztelumendi, A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.021 · Cited by 88 · see citing works
- Authors
- Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., & Ullrich, O.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Washington (US)
- Charité – Universitätsmedizin Berlin (DE)
- Max Delbrück Center (DE)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Ullrich, Oliver
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 49
- Issue
- 1
- Pages
- 67-79
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968740815
- Cited by
- 445
- References
- 76
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 12 · 2023: 14 · 2022: 26 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 18 · 2016: 25 · 2015: 29 · 2014: 23 · 2013: 20 · 2012: 31
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- University of Miami
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Heart, Lung, and Blood Institute (N01-HO-3284)
- National Institute of Mental Health (R24-MH-59724, R24MH059724)
- National Institute of Neurological Disorders and Stroke (NS-08952, NS-11920, R01NS008952)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- anandamide, endocannabinoid system, MKP-1, microglia, neuroinflammation, neuroprotection, CB1 receptor, CB2 receptor, MAPK signaling, histone H3 phosphorylation, neuroimmune interactions, pattern recognition receptors, excitotoxicity, secondary neuronal damage
- MeSH terms
- Adult, Animals, Arachidonic Acids, Cell Survival, Cells, Cultured, Encephalitis, Humans, Middle Aged, Multiple Sclerosis, Neurons, Nitric Oxide, Phosphoprotein Phosphatases, Phosphorylation, Tissue Distribution, Protein Tyrosine Phosphatases, Rats, Wistar, Microglia, Immediate-Early Proteins, Neuroprotective Agents, Cell Cycle Proteins, Nitric Oxide Synthase, MAP Kinase Signaling System, Receptors, Cannabinoid, Extracellular Signal-Regulated MAP Kinases, Mice, Rats, Polyunsaturated Alkamides, Dual Specificity Phosphatase 1, Protein Phosphatase 1, Cannabinoid Receptor Modulators, Endocannabinoids
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