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Cited by 166

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p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

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Ewen, M E, Oliver, C J, Sluss, H K, Miller, S J, Peeper, D S·1995·Genes & Development
DOI 10.1101/gad.9.2.204
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Abstract

Transforming growth factor beta 1 (TGF-beta 1) can cause a cell-cycle arrest in G1. Inhibition of cyclin-dependent kinase 4 (cdk4) synthesis plays a significant role in the mechanism by which this cytokine causes G1 growth arrest. Deregulated expression of cdk4 confers resistance to TGF-beta 1. Here, we show that TGF-beta 1 down-regulates cdk4 expression by inhibiting its translation. Moreover, mutant p53 confers resistance to TGF-beta 1 by interfering with the down-regulation of cdk4 in response to the cytokine. In contrast, we demonstrate that wild-type p53 represses the translation of CDK4. Regulation of cdk4 synthesis by both p53 and TGF-beta 1 is mediated by the 5'-untranslated region of the CDK4 message. Thus, regulation of CDK4 translation may be involved in control of G1 progression by p53.

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Metadata

Authors
Ewen, M. E., Oliver, C. J., Sluss, H. K., Miller, S. J., & Peeper, D. S.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1995-01-15
Volume
9
Issue
2
Pages
204-217
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.9.2.204
OpenAlex
W2069533174
Cited by
166
References
7
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest. https://app.cochat.ai/papers/10.1101/gad.9.2.204
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Ewen, M. E., Oliver, C. J., Sluss, H. K., Miller, S. J., & Peeper, D. S. (1995). p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest. Genes & Development. https://doi.org/10.1101/gad.9.2.204

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