Sleep enhances serum interleukin-7 concentrations in humans
Abstract
Growing evidence points towards a beneficial effect of sleep on immune function. Human studies indicate that the T cell mediated adaptive immune function including formation of antigen specific antibodies is facilitated by sleep. Along this line, here we aimed to dissociate the effect of sleep and circadian rhythm on circulating interleukin-7 (IL-7) and interleukin-15 (IL-15). These cytokines play a key role in the homeostatic regulation of naïve and memory T cell numbers and are critical for the differentiation of memory T cells. Serum IL-7 concentration and expression of membrane-bound IL-15 (mIL-15) on CD14(+) monocytes were measured in 18 men on two occasions: once during a regular 24-h sleep-wake cycle and another time during a 24-h period of continuous wakefulness. During sleep and especially during late sleep serum IL-7 concentrations were distinctly increased as compared to wakefulness (p<0.05). mIL-15 density on monocytes remained unchanged by sleep. The sleep-dependent increase in IL-7 concentration was associated with increased REM sleep, but did not correlate with concentrations of GH, cortisol or norepinephrine during sleep. The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory.
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There is evidence that sleep increases blood concentrations of IL-7, a cytokine fostering differentiation of T memory cells.
“Finally, there is evidence that sleep increases blood concentrations of IL-7, a cytokine fostering differentiation of T memory cells (76).”
From About Sleep's Role in Memory (2013) · cites this paper as [76]
Cites
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“The IL-7 signal and the ability to express IL-7Ra are essential during the contraction phase after the acute immune response, in which more than 95% of antigen-specific effector T cells become eliminated due to apoptosis, and for the development of CD8+ effector T cells to CD8+ memory T cells (Kaech et al., 2003).”
BackgroundStress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983 · see citing works
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Born, J., & Fehm, H. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211969 · Cited by 169 · cited 1× · see citing works
“In the present study, sleep induced the expected surge in GH concentration peaking during the early hours of the night (Born et al., 1988; Born and Fehm, 1998).”
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
“Finally, there is evidence that sleep increases blood concentrations of IL-7, a cytokine fostering differentiation of T memory cells (76).”
BackgroundSelf-citationBesedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153 · see citing works
Self-citationCrosstalk between the circadian clock circuitry and the immune system
Cermakian, N., Lange, T., Golombek, D., Sarkar, D., Nakao, A., Shibata, S., & Mazzoccoli, G. (2013) · Chronobiology International · doi:10.3109/07420528.2013.782315 · Cited by 279 · see citing works
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Self-citationSleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
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- Authors
- Benedict, C., Dimitrov, S., Marshall, L., & Born, J.
- Affiliations
- University of Lübeck (DE)
- Corresponding author
- Benedict, Christian
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 21
- Issue
- 8
- Pages
- 1058-1062
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2050705882
- Cited by
- 40
- References
- 4
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep, IL-7, IL-15, circadian rhythm, REM sleep, T cell homeostasis, memory T cells, naive T cells, CD14+ monocytes, memory T cell differentiation, immune function
- MeSH terms
- Adult, Circadian Rhythm, Humans, Hydrocortisone, Male, Monocytes, Norepinephrine, Reference Values, Sleep, T-Lymphocytes, Wakefulness, Interleukin-7, Lipopolysaccharide Receptors, Human Growth Hormone, Interleukin-15
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