Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
Open accessAbstract
Up to 80% of people develop a cutaneous condition closely connected to their exposure to stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with multifactorial etiology, including genetic background, environmental factors, and immune system disturbances with a strong cytokine component. Moreover, psoriasis is variably associated with sleep disturbance and sleep deprivation. This study evaluated the influence of sleep loss in the context of an animal model of psoriasis by measuring cytokine and stress-related hormone levels. Male adult Balb/C mice with or without psoriasis were subjected to 48 h of selective paradoxical sleep deprivation (PSD). Sleep deprivation potentiated the activities of kallikrein-5 and kallikrein-7 in the skin of psoriatic groups. Also, mice with psoriasis had significant increases in specific pro-inflammatory cytokines (IL-1β, IL-6 and IL-12) and decreases in the anti-inflammatory cytokine (IL-10) after PSD, which were normalized after 48 h of sleep rebound. Linear regression showed that IL-2, IL-6 and IL-12 levels predicted 66% of corticosterone levels, which were selectively increased in psoriasis mice subject to PSD. Kallikrein-5 was also correlated with pro-inflammatory cytokines, explaining 58% of IL-6 and IL-12 variability. These data suggest that sleep deprivation plays an important role in the exacerbation of psoriasis through modulation of the immune system in the epidermal barrier. Thus, sleep loss should be considered a risk factor for the development of psoriasis.
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Objective PSG and actigraphy show indicators of disrupted sleep in RA patients compared with healthy controls, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time.
“Based on objective PSG and actigraphy assessment, various indicators of disrupted sleep have been reported in RA patients compared with healthy control participants, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time (54, 160, 237, 351, 472).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [237]
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- Authors
- Hirotsu, C., Rydlewski, M., Araújo, M. S., Tufik, S., & Andersen, M. L.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-11-30
- Volume
- 7
- Issue
- 11
- Pages
- e51183
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3511390
- OpenAlex
- W2040997161
- Cited by
- 103
- References
- 76
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 12 · 2014: 10 · 2013: 1
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion, cc-by)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (98/14303-3)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CEPID 98/14303-3)
- Associação Fundo de Incentivo à Pesquisa (CEPID 98/14303-3)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- psoriasis, sleep deprivation, REM sleep deprivation, cytokines, kallikrein 5, kallikrein 7, interleukin-6, IL-12, IL-10, IL-1β, corticosterone, stress hormones, sleep rebound, skin barrier, immunomodulation
- MeSH terms
- Animals, Body Weight, Corticosterone, Disease Models, Animal, Kallikreins, Male, Mice, Inbred BALB C, Psoriasis, Skin, Sleep Deprivation, Stress, Psychological, Cytokines, Mice
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