Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza a H1N1 virus vaccination
Open accessAbstract
BACKGROUND: Experimental studies in humans have yielded evidence that adaptive immune function, including the production of antigen-specific antibodies, is distinctly impaired when sleep is deprived at the time of first antigen exposure. Here we examined the effects of a regular 24-hour sleep-wake cycle (including 8 hours of nocturnal sleep) and a 24-hour period of continuous wakefulness on the 7-week antibody production in 11 males and 13 females in response to the H1N1 (swine flu) virus vaccination. The specific antibody titer in serum was assayed by the hemagglutination inhibition test on the days 5, 10, 17, and 52 following vaccination. RESULTS: In comparison to the sleep group, sleep-deprived males but not females had reduced serum concentration of H1N1-specific antibodies five days after vaccination, whereas antibody titers at later time points did not differ between the conditions. CONCLUSIONS: These findings concur with the notion that sleep is a supportive influence in the very early stage of an adaptive immune response to a viral antigen. However, our results do not support the view that acute sleep deprivation has lasting effects on the human antibody titer response to influenza vaccination.
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After H1N1 vaccination, no sleep at night could reduce antigen-specific antibody response.
“After H1N1 vaccination, if there is no sleep at night, antigen-specific antibody response could be reduced [89].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [89]
In humans, DAMPs increase in the brain, CSF, and blood following acute sleep deprivation.
“in humans, DAMPs increase in the brain (509), CSF (410), and blood (35) following acute sleep deprivation.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [35]
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Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Van Cauter, E. (2000) · JAMA · doi:10.1001/jama.284.7.861 · Cited by 773 · see citing works
Effect of Sleep Deprivation on Response to Immunizaton
Spiegel, K. (2002) · JAMA · doi:10.1001/jama.288.12.1469 · Cited by 633 · see citing works
Effects of sleep and circadian rhythm on human circulating immune cells
Born, J., Lange, T., Hansen, K., Mölle, M., & Fehm, H. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4454 · Cited by 611 · see citing works
Effects of sleep and circadian rhythm on the human immune system
Lange, T., Dimitrov, S., & Born, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05300.x · Cited by 591 · see citing works
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Effect of Sleep Deprivation on Response to Immunizaton
Spiegel, K., Sheridan, J. F., & Cauter, E. V. (2002) · JAMA · doi:10.1001/jama.288.12.1471-a · Cited by 423 · see citing works
Sleep Enhances the Human Antibody Response to Hepatitis A Vaccination
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000091382.61178.f1 · Cited by 351 · see citing works
Sleep loss activates cellular markers of inflammation: Sex differences
Irwin, M. R., Carrillo, C., & Olmstead, R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.06.001 · Cited by 287 · see citing works
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00031-x · Cited by 268 · see citing works
Coin Rubbing and Camphor Intoxication—Reply
Bächli, E., Rampini, S. K., & Schneemann, M. (2002) · JAMA · doi:10.1001/jama.288.12.1471-b · Cited by 244 · see citing works
Dendritic cells and C‐type lectin receptors: coupling innate to adaptive immune responses
van Vliet, S. J., García-Vallejo, J. J., & van Kooyk, Y. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.55 · Cited by 182 · see citing works
Number and Function of Circulating Human Antigen Presenting Cells Regulated by Sleep
Dimitrov, S., Lange, T., Nohroudi, K., & Born, J. (2007) · Sleep · doi:10.1093/sleep/30.4.401 · Cited by 164 · see citing works
Effect of growth hormone (GH) on the immune system.
Meazza, C., Pagani, S., Travaglino, P., & Bozzola, M. (2004) · PubMed · Cited by 69 · see citing works
A manual of standardized terminology, techniques and scoring system for sleep of human subjects
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 60 · see citing works
Sha, B. E. (2000) · JAMA · doi:10.1001/jama.284.21.2717 · Cited by 45 · see citing works
Sleep enhances serum interleukin-7 concentrations in humans
Benedict, C., Dimitrov, S., Marshall, L., & Born, J. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.004 · Cited by 40 · see citing works
Self-citationSlow Wave Sleep and Release of Growth Hormone
Feinberg, I. (2000) · JAMA · doi:10.1001/jama.284.21.2717-c · Cited by 40 · see citing works
Sadamatsu, M., Kato, N., Iida, H., Takahashi, S., Sakaue, K., Takahashi, K., Hashida, S., & Ishikawa, E. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00797.x · Cited by 31 · see citing works
The immune recovery function of sleep – Tracked by neutrophil counts
Lange, T., & Born, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.008 · Cited by 30 · see citing works
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Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“Vaccinations with hepatitis A virus (320, 325) and influenza A H1N1 (swine flu) virus (34) in healthy participants appeared to not cause any gross sleep changes in the night following the vaccination, but there was no comparison of sleep data to a placebo-vaccinated control group in these studies.”
BackgroundInfluentialProbiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529 · see citing works
Sleep and Antibody Response to Hepatitis B Vaccination
Prather, A. A., Hall, M., Fury, J. M., Ross, D. C., Muldoon, M. F., Cohen, S., & Marsland, A. L. (2012) · SLEEP · doi:10.5665/sleep.1990 · Cited by 207 · see citing works
Dimitrov, S., Besedovsky, L., Born, J., & Lange, T. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.017 · Cited by 56 · see citing works
Besedovsky, L., Linz, B., Born, J., & Lange, T. (2014) · European Journal of Immunology · doi:10.1002/eji.201344265 · Cited by 31 · see citing works
Prather, A. A. (2019) · Sleep and Health · doi:10.1016/b978-0-12-815373-4.00024-1 · Cited by 27 · see citing works
Paradoxical sleep deprivation impairs mouse survival after infection with malaria parasites
Lungato, L., Gazarini, M. L., Paredes-Gamero, E. J., Tufik, S., & D’Almeida, V. (2015) · Malaria Journal · doi:10.1186/s12936-015-0690-7 · Cited by 21 · see citing works
- Authors
- Benedict, C., Brytting, M., Markström, A., Broman, J.-E., & Schiöth, H. B.
- Affiliations
- Uppsala University (SE)
- Swedish Institute (SE)
- Uppsala University Hospital (SE)
- Corresponding author
- Benedict, Christian
- Venue
- BMC Immunology
- Published
- 2012-01-04
- Volume
- 13
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1471-2172 (ISSN-L)
- PMC
- PMC3266189
- OpenAlex
- W2129904810
- Cited by
- 119
- References
- 20
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 12 · 2019: 9 · 2018: 3 · 2017: 13 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 1
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brain Research Foundation
- AstraZeneca
- Novo Nordisk
- Vetenskapsrådet
- Uppsala Universitet
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Keywords
- acute sleep deprivation, humoral immune response, sex differences, hemagglutination inhibition, adaptive immunity, sleep and immunity
- MeSH terms
- Antibodies, Viral, Antibody Formation, Female, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines, Male, Sleep, Sleep Deprivation, Vaccination, Titrimetry, Influenza A Virus, H1N1 Subtype, Young Adult
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