The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.
Adaptive immunity affects learning behavior in mice
Abstract
Regulation of neuronal plasticity by the immune system is an evolving field of modern neuroscience. Here we employ immune deficient mice to examine the role of the immune system in learning behavior of mice in a variety of cognitive tasks. While no motivation or motor function deficits are evident in severe combined immune deficient (scid) mice, there was significant impairment in acquisition of cognitive tasks as compared to wild-type (WT) control mice. Moreover, acute depletion of adaptive immunity in adult WT mice significantly impaired learning behavior. Passive transfer of autologous T cells into WT mice following ablation of adaptive immunity restored previously impaired cognitive function. These results suggest that throughout lifetime, immune system supports cognitive function and may therefore have far-reaching therapeutic implications for cognitive disorders.
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“immune deficiency in mice causes cognitive impairments that are reversed by replenishment of CD4+ T cells (23–27)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [25]
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Self-citationAutoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
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Cytokine-induced sickness behavior
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Sex differences in neuronal differentiation of human stem cells
Doszyn, O. (2019) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
Li, H., Fu, Z., Hu, M., & Xu, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.739580
Wang, Y. (2023) · Lecture Notes in Education Psychology and Public Media · doi:10.54254/2753-7048/30/20231617
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Self-citationMi, T., Yang, S., Wang, N., Huo, F., Zhao, M., Lv, S., Su, T., Feng, S., Guo, L., Guo, L., et al. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00538-4
Self-citationAlbekairi, T. H., Albakheet, A. S., Alosaimi, T. H., Bakheet, S. A., Nadeem, A., Attia, S. M., Ansari, M. A., Hussein, M. H., Mahmoud, M. A., & Ahmad, S. F. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578810
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CD4 T lymphocytes shape the development and maturation of the central nervous system
de Carvalho, P. F., Xavier, F. H. D. C., Cerqueira, E., de Souza, L. B., Vianna, P. H. O., Santos, Á. R. C., Galvani, R. G. A., Savino, W., Frozza, R. L., & Bonomo, A. C. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112058
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Metadata
- Authors
- Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Kipnis, Jonathan
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 22
- Issue
- 6
- Pages
- 861-869
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2052042076
- Cited by
- 221
- References
- 36
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 15 · 2020: 11 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 20 · 2015: 12 · 2014: 14 · 2013: 18 · 2012: 12
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Nebraska Medical Center
- Nebraska Tobacco Settlement Biomedical Research Development Fund
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- adaptive immunity, learning behavior, cognitive function, immunodeficiency, T cell transfer, neuroplasticity, cognitive impairment, neuroimmunology
- MeSH terms
- Adaptation, Physiological, Animals, Behavior, Animal, Cognition, Immunity, Learning, Male, Memory, Mice, Inbred BALB C, Mice, Inbred C57BL, Motor Activity, Species Specificity, Mice, SCID, Maze Learning, Rotarod Performance Test, Mice
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