T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works

The role of immune dysfunction in the pathophysiology of autism

Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635 · see citing works

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works

IL-4 in the brain: a cytokine to remember

Gadani, S. P., Cronk, J. C., Norris, G. T., & Kipnis, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202246 · Cited by 549 · see citing works

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works

The immune response in autism: a new frontier for autism research

Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works

The microbiota regulate neuronal function and fear extinction learning

Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421 · see citing works

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368 · see citing works

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

Schwartz, M., & Baruch, K. (2014) · The EMBO Journal · doi:10.1002/embj.201386609 · Cited by 349 · see citing works

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348 · see citing works

Modeling an autism risk factor in mice leads to permanent immune dysregulation

Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340 · see citing works

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory

Ribeiro, M., Brigas, H. C., Temido-Ferreira, M., Pousinha, P. A., Regen, T., Santa, C., Coelho, J. E., Marques-Morgado, I., Valente, C. A., Omenetti, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay5199 · Cited by 335 · see citing works

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis

Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801218 · Cited by 329 · see citing works

Advances in Meningeal Immunity

Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326 · see citing works

Altered T cell responses in children with autism

Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.002 · Cited by 281 · see citing works

Immune cells and CNS physiology: Microglia and beyond

Norris, G. T., & Kipnis, J. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180199 · Cited by 274 · see citing works

Inflammatory T helper 17 cells promote depression-like behavior in mice

Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254 · see citing works

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246 · see citing works

Systemic inflammatory cells fight off neurodegenerative disease

Schwartz, M., & Shechter, R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.71 · Cited by 240 · see citing works

Peripheral immune system in aging and Alzheimer’s disease

Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214 · see citing works

Adaptive immunity affects learning behavior in mice

Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.008 · Cited by 221 · see citing works

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199 · see citing works

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. (2021) · Science Advances · doi:10.1126/sciadv.abe4601 · Cited by 172 · see citing works

The Choroid Plexus in Healthy and Diseased Brain

Kaur, C., Rathnasamy, G., & Ling, E.-A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv030 · Cited by 176 · see citing works

Learning and memory … and the immune system

Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166 · see citing works

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167 · see citing works

Understanding the Role of T Cells in CNS Homeostasis

Ellwardt, E., Walsh, J. T., Kipnis, J., & Zipp, F. (2016) · Trends in Immunology · doi:10.1016/j.it.2015.12.008 · Cited by 156 · see citing works

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works

Reducing post-traumatic anxiety by immunization

Lewitus, G. M., Cohen, H., & Schwartz, M. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.05.002 · Cited by 123 · see citing works

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

Doty, K. R., Guillot-Sestier, M.-V., & Town, T. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.008 · Cited by 104 · see citing works

Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?

Kipnis, J., Derecki, N. C., Yang, C., & Scrable, H. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.007 · Cited by 90 · see citing works

Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia

Brambilla, P., Bellani, M., Isola, M., Bergami, A., Marinelli, V, Dusi, N., Rambaldelli, G., Tansella, M., Maria Finardi, A., Martino, G., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.46 · Cited by 86 · see citing works

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88 · see citing works

MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression

Nelson, P. A., Sage, J. R., Wood, S. C., Davenport, C. M., Anagnostaras, S. G., & Boulanger, L. M. (2013) · Learning & Memory · doi:10.1101/lm.031351.113 · Cited by 49 · see citing works

Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm

Panoskaltsis, N., McCarthy, N. E., Stagg, A. J., Mummery, C. J., Husni, M., Arebi, N., Greenstein, D., Price, C. L., Al-Hassi, H. O., Koutinas, M., et al. (2021) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-020-02725-2 · Cited by 16 · see citing works

TREM2-dependent senescent microglia conserved in aging and Alzheimer’s disease

Rachmian, N., Medina, S., Cherqui, U., Akiva, H., Deitch, D., Edilbi, D., Croese, T., Salame, T., Peralta Ramos, J., Cahalon, L., et al. (2023) · doi:10.1101/2023.03.20.533401 · Cited by 6 · see citing works