Adaptive immunity affects learning behavior in mice

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882

CNS immune privilege: hiding in plain sight

Carson, M. J., Doose, J. M., Melchior, B., Schmid, C. D., & Ploix, C. C. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00441.x · Cited by 838

Cytokine-induced sickness behavior

Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510

Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

Flügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 407

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388

Neuroprotection by Encephalomyelitis: Rescue of Mechanically Injured Neurons and Neurotrophin Production by CNS-Infiltrating T and Natural Killer Cells

Hammarberg, H., Lidman, O., Lundberg, C., Eltayeb, S., Gielen, A. W., Muhallab, S., Svenningsson, A., Lindå, H., van der Meide, P. H., Cullheim, S., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05283.2000 · Cited by 311

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682

IL-4 in the brain: a cytokine to remember

Gadani, S. P., Cronk, J. C., Norris, G. T., & Kipnis, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202246 · Cited by 549

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514

Human immunodeficiency virus‐associated neurocognitive disorders: Mind the gap

McArthur, J. C., Steiner, J. P., Sacktor, N. C., & Nath, A. (2010) · Annals of Neurology · doi:10.1002/ana.22053 · Cited by 454

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348

Modeling an autism risk factor in mice leads to permanent immune dysregulation

Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340

Depression and immunity: A role for T cells?

Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 345

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis

Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801218 · Cited by 329

Advances in Meningeal Immunity

Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326

Neuroplastic changes in depression: A role for the immune system

Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 295

Inflammatory T helper 17 cells promote depression-like behavior in mice

Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246

The role of T cells in age-related diseases

Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 250

Cytokines as emerging regulators of central nervous system synapses

Zipp, F., Bittner, S., & Schafer, D. P. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.011 · Cited by 257

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236

Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders

Garay, P. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00136 · Cited by 217

Peripheral immune system in aging and Alzheimer’s disease

Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214

Interactions of innate and adaptive immunity in brain development and function

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 229

Microglial Activation – Tuning and Pruning Adult Neurogenesis

Ekdahl, C. T. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00041 · Cited by 218

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Hait, N. C., Wise, L. E., Allegood, J. C., O'Brien, M., Avni, D., Reeves, T. M., Knapp, P. E., Lu, J., Luo, C., Miles, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3728 · Cited by 209

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms

Heuer, L., Ashwood, P., Schauer, J., Goines, P., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., Croen, L. A., Pessah, I. N., & Van de Water, J. (2008) · Autism Research · doi:10.1002/aur.42 · Cited by 190

Neuroimmunological effects of physical exercise in depression

Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 201

Learning and memory … and the immune system

Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

Ricci, S., Businaro, R., Ippoliti, F., Vasco, V. R. L., Massoni, F., Onofri, E., Troili, G. M., Pontecorvi, V., Morelli, M., Ricciardi, M. R., et al. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9393-4 · Cited by 170

Evidence supporting an altered immune response in ASD

Mead, J., & Ashwood, P. (2015) · Immunology Letters · doi:10.1016/j.imlet.2014.11.006 · Cited by 165

Role of neuro-immunological factors in the pathophysiology of mood disorders

Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149

Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

Eyre, H. A., Papps, E., & Baune, B. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00003 · Cited by 153

Alterations in Immune Cells and Mediators in the Brain: It's Not Always Neuroinflammation!

Estes, M. L., & McAllister, A. K. (2014) · Brain Pathology · doi:10.1111/bpa.12198 · Cited by 150

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

Smith, C. J., Emge, J. R., Berzins, K., Lung, L., Khamishon, R., Shah, P., Rodrigues, D. M., Sousa, A. J., Reardon, C., Sherman, P. M., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00238.2014 · Cited by 143

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

Brunkhorst, R., Vutukuri, R., & Pfeilschifter, W. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00283 · Cited by 150

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

Radjavi, A., Smirnov, I., & Kipnis, J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.013 · Cited by 141

Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice

Brachman, R. A., Lehmann, M. L., Maric, D., & Herkenham, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2278-14.2015 · Cited by 130

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer’s Disease

Melchior, B., Garcia, A., Hsiung, B., Lo, K. M., Doose, J. M., Thrash, J. C., Stalder, A. K., Staufenbiel, M., Neumann, H., & Carson, M. J. (2010) · ASN NEURO · doi:10.1042/an20100010 · Cited by 134

IL-13–Mediated Regulation of Learning and Memory

Brombacher, T. M., Nono, J. K., Gouveia, K. S. D., Makena, N., Darby, M., Womersley, J. S., Tamgue, O., & Brombacher, F. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601546 · Cited by 133

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129

Cognitive Function and the Microbiome

Gareau, M. G. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.001 · Cited by 138

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 134

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

Monteiro, S., Ferreira, F. M., Pinto, V., Roque, S., Morais, M., Calçada, D. D. S., Mota, C., Correia‐Neves, M., & Cerqueira, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.194 · Cited by 133

Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats

Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117

Correlates of cognitive dysfunction in multiple sclerosis

Heesen, C., Schulz, K., Fiehler, J., Mark, U., Otte, C., Jung, R., Poettgen, J., Krieger, T., & Gold, S. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.05.006 · Cited by 116

Meningeal macrophages protect against viral neuroinfection

Rebejac, J., Eme‐Scolan, E., Arnaud, L., Kharbouche, S., Teleman, M., Spinelli, L., Gallo, E., Roussel‐Queval, A., Zarubica, A., Sansoni, A., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.005 · Cited by 116

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

Radjavi, A., Smirnov, I., Derecki, N., & Kipnis, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.79 · Cited by 112

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

Rattazzi, L., Piras, G., Ono, M., Deacon, R. M. J., Pariante, C. M., & D’Acquisto, F. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.54 · Cited by 108

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Worthen, R. J., Zighelboim, S. S. G., Jaramillo, C., & Beurel, E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01922-1 · Cited by 113

Affective immunology: where emotions and the immune response converge

D’Acquisto, F. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/fdacquisto · Cited by 108

Ingestion of mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice

Matthews, D. M., & Jenks, S. M. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.02.007 · Cited by 105

The immune system as a novel regulator of sex differences in brain and behavioral development

Nelson, L. H., & Lenz, K. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23821 · Cited by 118

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 102

Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?

Kipnis, J., Derecki, N. C., Yang, C., & Scrable, H. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.007 · Cited by 90

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88

Immune Dysregulation in Autism Spectrum Disorder

Hsiao, E. Y. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00009-5 · Cited by 87

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity

Schwartz, M., London, A., & Shechter, R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.013 · Cited by 91

The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia

Vidal, P. M., & Pacheco, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00394 · Cited by 92

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 87

Unique aspects of IFN ‐γ/ STAT1 signaling in neurons

Clark, D. N., Begg, L. R., & Filiano, A. J. (2022) · Immunological Reviews · doi:10.1111/imr.13092 · Cited by 82

Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

Matejuk, A., Vandenbark, A. A., & Offner, H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.672455 · Cited by 81

Neuroimmunology of depression

Sarno, E., Moeser, A. J., & Robison, A. J. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.03.004 · Cited by 84

Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression

Bhattacharya, A., & Drevets, W. C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_43 · Cited by 76

Immunity to self and self-maintenance: a unified theory of brain pathologies

Schwartz, M., & Ziv, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.01.003 · Cited by 74

Brain interference: Revisiting the role of IFNγ in the central nervous system

Monteiro, S., Roque, S., Marques, F., Correia‐Neves, M., & Cerqueira, J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.003 · Cited by 75

Age-dependent spatial memory loss can be partially restored by immune activation

Ron-Harel, N., Segev, Y., Lewitus, G. M., Cardon, M., Ziv, Y., Netanely, D., Jacob-Hirsch, J., Amariglio, N., Rechavi, G., Domany, E., et al. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0755 · Cited by 73

The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges

Kuijer, E. J., & Steenbergen, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105296 · Cited by 76

A conceptual revolution in the relationships between the brain and immunity

Schwartz, M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.015 · Cited by 73

Active Immunization with Amyloid-β 1–42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

Vollmar, P., Kullmann, J. S., Thilo, B., Claussen, M. C., Rothhammer, V., Jacobi, H., Sellner, J., Nessler, S., Korn, T., & Hemmer, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001765 · Cited by 68

T cells establish and maintain CNS viral infection in HIV-infected humanized mice

Honeycutt, J. B., Liao, B., Nixon, C. C., Cleary, R. A., Thayer, W. O., Birath, S., Swanson, M. D., Sheridan, P. A., Zakharova, O. I., Prince, F., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98968 · Cited by 63

Adaptive Immunity in Schizophrenia: Functional Implications of T Cells in the Etiology, Course and Treatment

Debnath, M. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9626-9 · Cited by 60

Breaking Boundaries in Neural-Immune Interactions

McAllister, A. K., & de Water, J. V. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.038 · Cited by 59

Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?

Ron‐Harel, N., & Schwartz, M. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.03.003 · Cited by 60

CD8+ T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity

Zarif, H., Nicolas, S., Guyot, M., Hosseiny, S., Lazzari, A., Canali, M. M., Cazareth, J., Brau, F., Golzné, V., Dourneau, E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.016 · Cited by 56

Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

Garofalo, S., Cocozza, G., Mormino, A., Bernardini, G., Russo, E., Ielpo, D., Andolina, D., Ventura, R., Martinello, K., Renzi, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38899-3 · Cited by 55

A Non-inflammatory Role for Microglia in Autism Spectrum Disorders

Edmonson, C. A., Ziats, M. N., & Rennert, O. M. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00009 · Cited by 56

Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases

Salimi, H., & Klein, R. S. (2019) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-19515-1_7 · Cited by 56

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

Petersen, L. E., Grassi‐Oliveira, R., Baptista, T. S. A., dos Santos, S. G. R., Ilha, M., Nardi, T. D., Keisermann, M., & Bauer, M. E. (2014) · NeuroImmunoModulation · doi:10.1159/000358437 · Cited by 52

Contributions of monocytes to nervous system disorders

Garré, J. M., & Yang, G. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1672-3 · Cited by 53

Rett syndrome and other autism spectrum disorders—brain diseases of immune malfunction?

Derecki, N. C., Privman, E., & Kipnis, J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.21 · Cited by 50

Increased circulating regulatory T cells in medicated people with schizophrenia

Kelly, D. L., Li, X., Kilday, C., Feldman, S. M., Clark, S. M., Liu, F., Buchanan, R. W., & Tonelli, L. H. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.006 · Cited by 53

The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology

Amoriello, R., Memo, C., Ballerini, L., & Ballerini, C. (2024) · Molecular Brain · doi:10.1186/s13041-024-01077-7 · Cited by 47

Senescence-accelerated Mice (SAMs) as a Model for Brain Aging and Immunosenescence.

Shimada, A., & Hasegawa‐Ishii, S. (2011) · Europe PMC (PubMed Central) · Cited by 45

Lymphocytes in neuroprotection, cognition and emotion: Is intolerance really the answer?

Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.005 · Cited by 44

Cohorts based on decade of death: No evidence for secular trends favoring later cohorts in cognitive aging and terminal decline in the AHEAD study.

Hülür, G., Infurna, F. J., Ram, N., & Gerstorf, D. (2012) · Psychology and Aging · doi:10.1037/a0029965 · Cited by 43

Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

Beurel, E., Harrington, L. E., Buchser, W., Lemmon, V., & Jope, R. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086257 · Cited by 43

Meningeal immunity: Structure, function and a potential therapeutic target of neurodegenerative diseases

Ma, T., Wang, F., Xu, S., & Huang, J. H. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.028 · Cited by 38

Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?

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