Adaptive immunity affects learning behavior in mice

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882

CNS immune privilege: hiding in plain sight

Carson, M. J., Doose, J. M., Melchior, B., Schmid, C. D., & Ploix, C. C. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00441.x · Cited by 838

Cytokine-induced sickness behavior

Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510

Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

Flügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 407

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388

Neuroprotection by Encephalomyelitis: Rescue of Mechanically Injured Neurons and Neurotrophin Production by CNS-Infiltrating T and Natural Killer Cells

Hammarberg, H., Lidman, O., Lundberg, C., Eltayeb, S., Gielen, A. W., Muhallab, S., Svenningsson, A., Lindå, H., van der Meide, P. H., Cullheim, S., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05283.2000 · Cited by 311

Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

Sparkman, N. L., Buchanan, J. B., Heyen, J. R. R., Chen, J., Beverly, J. L., & Johnson, R. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3376-06.2006 · Cited by 307

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299

The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System

Pachter, J. S., de Vries, H. E., & Fábry, Z. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.6.593 · Cited by 293

Neurotrophic cross‐talk between the nervous and immune systems: Implications for neurological diseases

Kerschensteiner, M., Stadelmann, C., Dechant, G., Wekerle, H., & Hohlfeld, R. (2003) · Annals of Neurology · doi:10.1002/ana.10446 · Cited by 275

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

Kipnis, J., Yoles, E., Schori, H., Hauben, E., Shaked, I., & Schwartz, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04564.2001 · Cited by 230

Autoimmune T cells as potential neuroprotective therapy for spinal cord injury

Hauben, E., Nevo, U., Yoles, E., Moalem‐Taylor, G., Agranov, E., Mor, F., AKSELROD, S., Neeman, M., Cohen, I., & Schwartz, M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05140-5 · Cited by 213

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. W., Hope, C. E., Hatcher-Martin, J. M., DiCarlo, G., Gottschall, W. P. E., Morgan, D., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00249-9 · Cited by 199

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears β-amyloid in a mouse model of Alzheimer disease

Frenkel, D., Maron, R., Burt, D. S., & Weiner, H. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23241 · Cited by 189

Innate and Adaptive Immune Responses of the Central Nervous System

Bailey, S. L., Carpentier, P. A., McMahon, E., Begolka, W. S., & Miller, S. D. (2006) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v26.i2.40 · Cited by 182

Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response

Karni, A., Abraham, M., Monsonego, A., Cai, G., Freeman, G. J., Hafler, D. A., Khoury, S. J., & Weiner, H. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.4196 · Cited by 177

Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

Wilcock, D. M., Alamed, J., Gottschall, P. E., Grimm, J., Rosenthal, A., Pons, J., Ronan, V., Symmonds, K., Gordon, M. N., & Morgan, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0695-06.2006 · Cited by 155

Butovsky, O. et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl Acad. Sci. USA 103, 11784-11789

Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144

Subcutaneous Nogo Receptor Removes Brain Amyloid-β and Improves Spatial Memory in Alzheimer's Transgenic Mice

Park, J. H., Widi, G. A., Gimbel, D. A., Harel, N. Y., Lee, D. H. S., & Strittmatter, S. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4504-06.2006 · Cited by 109

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

Abraham, J., Jang, S., Godbout, J. P., Chen, J., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.002 · Cited by 74

Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS

Ling, C., Sándor, M., Suresh, M., & Fábry, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3502-05.2006 · Cited by 66

Immune Protection of the Brain—Efficient and Delicate

Wekerle, H. (2002) · The Journal of Infectious Diseases · doi:10.1086/344937 · Cited by 60

Intra-hippocampal microinjections of anisomycin did not block glucocorticoid-induced impairment of memory retrieval in rats: An evidence for non-genomic effects of glucocorticoids

Sajadi, A., Samaei, A., & Rashidy‐Pour, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.018 · Cited by 57

Breaking Ignorance: The Case of the Brain

Wekerle, H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_2 · Cited by 50

Intracerebral regulation of immune responses

Aloisi, F., Ambrosini, E., Cabezas, S. C., Magliozzi, R., & Serafini, B. (2001) · Annals of Medicine · doi:10.3109/07853890108995960 · Cited by 46

Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

Burgess, W., Gheusi, G., Yao, J. S., Johnson, R. W., Dantzer, R., & Kelley, K. W. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.6.r1829 · Cited by 43

Breaking or making immunological privilege in the central nervous system: The regulation of immunity by neuropeptides

Reinke, E. K., & Fábry, Z. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.11.009 · Cited by 32

Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine

Barnes, C. A., Eppich, C., & RAO, G. R. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90045-6 · Cited by 32

IL-1β Suppresses Prolonged Akt Activation and Expression of E2F-1 and Cyclin A in Breast Cancer Cells

Shen, W. H., Jackson, S. T., Broussard, S. R., McCusker, R. H., Strle, K., Freund, G. G., Johnson, R. W., Dantzer, R., & Kelley, K. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7272 · Cited by 21

Lethally irradiated normal strains of mice radioprotected with SCID bone marrow develop sensitivity to low doses of staphylococcal enterotoxin B

Aboud-Pirak, E., Lubin, I., Pirak, M., Canaan, A., Lowell, G. H., & Reisner, Y. (1995) · Immunology Letters · doi:10.1016/0165-2478(94)00005-c · Cited by 7

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682

Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval

Li, H., Fu, Z., Hu, M., & Xu, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.739580

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 102

Meningeal Immunity, Learning and Memory, and IL-4: Do T cells Make You Smart? (87.35)

Derecki, N. C., Cardani, A. N., Quinnies, K. M., Crihfield, A., Lynch, K., & Kipnis, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.87.35 · Cited by 3

Can a good immune system reduce ageing?

Siva, N. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70367-2

Effects of Brain-Derived IL-2 Deficiency and the Development of Autoimmunity on Spatial Learning and Fear Conditioning

Petitto, J. M. (2015) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000196 · Cited by 18