The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.
Adaptive immunity affects learning behavior in mice
Abstract
Regulation of neuronal plasticity by the immune system is an evolving field of modern neuroscience. Here we employ immune deficient mice to examine the role of the immune system in learning behavior of mice in a variety of cognitive tasks. While no motivation or motor function deficits are evident in severe combined immune deficient (scid) mice, there was significant impairment in acquisition of cognitive tasks as compared to wild-type (WT) control mice. Moreover, acute depletion of adaptive immunity in adult WT mice significantly impaired learning behavior. Passive transfer of autologous T cells into WT mice following ablation of adaptive immunity restored previously impaired cognitive function. These results suggest that throughout lifetime, immune system supports cognitive function and may therefore have far-reaching therapeutic implications for cognitive disorders.
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“immune deficiency in mice causes cognitive impairments that are reversed by replenishment of CD4+ T cells (23–27)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [25]
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From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209
Self-citationAutoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882
CNS immune privilege: hiding in plain sight
Carson, M. J., Doose, J. M., Melchior, B., Schmid, C. D., & Ploix, C. C. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00441.x · Cited by 838
Cytokine-induced sickness behavior
Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716
Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510
Self-citationFlügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431
Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 407
Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388
Hammarberg, H., Lidman, O., Lundberg, C., Eltayeb, S., Gielen, A. W., Muhallab, S., Svenningsson, A., Lindå, H., van der Meide, P. H., Cullheim, S., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05283.2000 · Cited by 311
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Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800
Self-citationUnexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697
Self-citationRevisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682
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Metadata
- Authors
- Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Kipnis, Jonathan
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 22
- Issue
- 6
- Pages
- 861-869
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2052042076
- Cited by
- 221
- References
- 36
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 15 · 2020: 11 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 20 · 2015: 12 · 2014: 14 · 2013: 18 · 2012: 12
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Nebraska Medical Center
- Nebraska Tobacco Settlement Biomedical Research Development Fund
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- adaptive immunity, learning behavior, cognitive function, immunodeficiency, T cell transfer, neuroplasticity, cognitive impairment, neuroimmunology
- MeSH terms
- Adaptation, Physiological, Animals, Behavior, Animal, Cognition, Immunity, Learning, Male, Memory, Mice, Inbred BALB C, Mice, Inbred C57BL, Motor Activity, Species Specificity, Mice, SCID, Maze Learning, Rotarod Performance Test, Mice
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