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Cited by 126Cancer, Stress, Anesthesia, and Immune ResponseOvarian cancer diagnosis and treatmentTryptophan and brain disorders

Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients

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Lutgendorf, Susan K., Lamkin, Donald M., DeGeest, Koen, Anderson, Barrie, Dao, Minh, McGinn, Stephanie, Zimmerman, Bridget, Maiseri, Heena +2 more·2008·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2007.12.012PMC PMC2605940
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Abstract

The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFN gamma), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4(+)) and T-cytotoxic (CD8(+)) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values<0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values<0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4(+) cells producing IFN gamma (TH(1) cells) vs. IL-4 (TH(2) cells) in all compartments (depressed mood: P=0.012; anxiety: P=0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8(+) cells producing IFN gamma (TC(1)) vs. IL-4 (TC(2)) (P=0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.

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  • MDD may predict lower T-cell cytokine expression.

    “Some studies have also reported that MDD may predict lower T-cell cytokine expression and reduce treatment adherence or initiation87,88, while improvement in depressive symptoms has been associated with increased survival in people with cancer89.”

    From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [87]

    The Results (§3.5; page not specified) associate higher depressed-mood scores with lower Type-1/Type-2 cytokine-expressing T-cell ratios in polyclonally stimulated cells. The study measured self-reported mood, not an MDD diagnosis, and its Limitations (§4.2; page not specified) say the findings are correlational; they do not establish that MDD predicts lower T-cell cytokine expression generally. (LLM, conf=0.87)

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  • MDD may reduce treatment adherence or initiation in people with cancer.

    “Some studies have also reported that MDD may predict lower T-cell cytokine expression and reduce treatment adherence or initiation87,88, while improvement in depressive symptoms has been associated with increased survival in people with cancer89.”

    From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [87]

    The psychosocial assessments section measures depressed mood, not diagnosed MDD, and the Results examine its association with T-cell cytokine ratios. Searches for treatment adherence and initiation found no passage addressing either outcome, so our copy cannot verify the attributed claim. (LLM, conf=0.76)

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3 of the 68 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. American Cancer Society . Cancer facts and figures. Atlanta, GA: 2007. [Google Scholar]
  2. Antoni M, Cruess D, Wagner S, Lutgendorf S, Kumar M, Ironson G, Klimas N, Fletcher M, Schneiderman N. Cognitive behavioral stress management reduces anxiety and 24-hour urinary catecholamine output among symptomatic HIV-infected gay men. J. Consult. Clin. Psychol. 2000;66:31–45. doi: 10.1037//0022-006x.68.1.31. [DOI] [PubMed] [Google Scholar] · DOI
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Authors
Lutgendorf, S. K., Lamkin, D. M., DeGeest, K., Anderson, B., Dao, M., McGinn, S., Zimmerman, B., Maiseri, H., Sood, A. K., & Lubaroff, D. M.
Affiliations
  • University of Iowa (US)
  • The University of Texas Medical Branch at Galveston (US)
  • The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Lutgendorf, Susan K.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2008-08
Volume
22
Issue
6
Pages
890-900
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2007.12.012
PMC
PMC2605940
OpenAlex
W2095272581
Cited by
126
References
68
Citations by year
2026: 6 · 2025: 3 · 2023: 49 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 13
FWCI
3.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R21CA088293, R21 CA 88293, R01CA104825)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
ovarian cancer, depressive mood, anxiety, T cell cytokines, interferon-gamma, IL-4, Th1/Th2 balance, tumor-infiltrating lymphocytes, ascites, tumor microenvironment, adaptive immunity, psychosocial factors, CD4+ T cells, CD8+ T cells
MeSH terms
Aged, Anxiety, Cells, Cultured, Depression, Female, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Interferon Type I, Lymphocyte Activation, Lymphocytes, Middle Aged, Ovarian Neoplasms, Surveys and Questionnaires, T-Lymphocytes, Cytotoxic, Interleukin-4, Cytokines

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