Cited by 172Posttraumatic Stress Disorder ResearchStress Responses and CortisolT-cell and B-cell Immunology

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Substantial reduction of naïve and regulatory T cells following traumatic stress

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Sommershof, Annette, Aichinger, Hannah, Engler, Harald, Adenauer, Hannah, Catani, Claudia, Boneberg, Eva-Maria, Elbert, Thomas, Groettrup, Marcus, Kolassa, Iris-Tatjana·2009·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2009.07.003

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Abstract

Posttraumatic stress disorder (PTSD) is associated with an enhanced susceptibility to various somatic diseases. However, the exact mechanisms linking traumatic stress to subsequent physical health problems have remained unclear. This study investigated peripheral T lymphocyte differentiation subsets in 19 individuals with war and torture related PTSD compared to 27 non-PTSD controls (n=14 trauma-exposed controls; n=13 non-exposed controls). Peripheral T cell subpopulations were classified by their characteristic expression of the lineage markers CD45RA and CCR7 into: naïve (CD45RA(+) CCR7(+)), central memory (T(CM): CD45RA(-) CCR7(+)) and effector memory (T(EM): CD45RA(-) CCR7(-) and T(EMRA): CD45RA(-) CCR7(-)) cells. Furthermore, we analyzed regulatory T cells (CD4(+)CD25(+)FoxP3(+)) and ex vivo proliferation responses of peripheral blood mononuclear cells after stimulation with anti-CD3 monoclonal antibody. Results show that the proportion of naïve CD8(+) T lymphocytes was reduced by 32% (p=0.01), whereas the proportions of CD3(+) central (p=0.02) and effector (p=0.01) memory T lymphocytes were significantly enhanced (+22% and +34%, respectively) in PTSD patients compared to non-PTSD individuals. To a smaller extent, this effect was also observed in trauma-exposed non-PTSD individuals, indicating a cumulative effect of traumatic stress on T cell distribution. Moreover, PTSD patients displayed a 48% reduction in the proportion of regulatory T cells (p<0.001). Functionally, these alterations were accompanied by a significantly enhanced (+34%) ex vivo proliferation of anti-CD3 stimulated T cells (p=0.05). The profoundly altered composition of the peripheral T cell compartment might cause a state of compromised immune responsiveness, which may explain why PTSD patients show an increased susceptibility to infections, and inflammatory and autoimmune diseases.

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Authors: Sommershof, A., Aichinger, H., Engler, H., Adenauer, H., Catani, C., Boneberg, E.-M., Elbert, T., Groettrup, M., & Kolassa, I.-T.
Affiliations: University of Konstanz (DE)
Essen University Hospital (DE)
Bielefeld University (DE)
ORCID: Engler, Harald
Catani, Claudia
Elbert, Thomas
Groettrup, Marcus
Kolassa, Iris-Tatjana
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2009-11
Volume: 23
Issue: 8
Pages: 1117-1124
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2009.07.003
OpenAlex: W1982301384
Semantic Scholar: 23eda2aa2cfa505a1b93574b87c419c3c31454ba
Cited by: 172
References: 55
Citations by year: 2026: 5 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 15 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 8
FWCI: 10.24
Type: journal article
Language: en
Open access: green
nbn-resolving.de
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
KOPS (University of Konstanz) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (FOR751)
European Refugee Fund
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: post-traumatic stress disorder, traumatic stress, T cell differentiation, naive T cells, regulatory T cells, central memory T cells, effector memory T cells, CD45RA, CCR7, T cell proliferation, immune dysfunction, trauma-exposed individuals
MeSH terms: Adult, Analysis of Variance, Cell Count, Combat Disorders, Female, Flow Cytometry, Humans, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Psychological Tests, Stress Disorders, Post-Traumatic, T-Lymphocytes, Cell Lineage, Cell Proliferation

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Substantial reduction of naïve and regulatory T cells following traumatic stress

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