Cited by 108Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Acute amygdaloid response to systemic inflammation.

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Engler, Harald, Doenlen, Raphael, Engler, Andrea, Riether, Carsten, Prager, Geraldine, Niemi, Maj-Britt, Pacheco-López, Gustavo, Krügel, Ute +1 more·2011·Brain, Behavior, and Immunity

Abstract

The amygdala, a group of nuclei located in the medial temporal lobe, is a key limbic structure involved in mood regulation, associative learning, and modulation of cognitive functions. Functional neuroanatomical studies suggest that this brain region plays also an important role in the central integration of afferent signals from the peripheral immune system. In the present study, intracerebral electroencephalography and microdialysis were employed to investigate the electrophysiological and neurochemical consequences of systemic immune activation in the amygdala of freely moving rats. Intraperitoneal administration of bacterial lipopolysaccharide (100 μg/kg) induced with a latency of about 2 h a significant increase in amygdaloid neuronal activity and a substantial rise in extracellular noradrenaline levels. Activated neurons in the amygdaloid complex, identified by c-Fos immunohistochemistry, were mainly located in the central nucleus and, to a lesser extent, in the basolateral nucleus of the amygdala. Gene expression analysis in micropunches of the amygdala revealed that endotoxin administration induced a strong time-dependent increase in IL-1β, IL-6, and TNF-α mRNA levels indicating that these cytokines are de novo synthesized in the amygdala in response to peripheral immune activation. The changes in amygdaloid activity were timely related to an increase in anxiety-like behavior and decreased locomotor activity and exploration in the open-field. Taken together, these dat…

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Crossref · 10.1016/j.bbi.2011.04.005

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  • Recent work in rodents demonstrated enhanced neural activity in the amygdala after peripheral LPS-administration.

    “This hypothesis is supported by recent work in rodents, which demonstrated enhanced neural activity in the amygdala after peripheral LPS-administration [59], [60].”

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Authors
Engler, H., Doenlen, R., Engler, A., Riether, C., Prager, G., Niemi, M.-B., Pacheco-López, G., Krügel, U., & Schedlowski, M.
Affiliations
  • ETH Zurich (CH)
  • Essen University Hospital (DE)
  • Leipzig University (DE)
Corresponding author
Engler, Harald
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2011-10
Volume
25
Issue
7
Pages
1384-1392
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2058197277
Cited by
108
References
71
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 11 · 2012: 12
FWCI
2.59
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • Cooper Fund
  • German Research Foundation (SCHE 341/13-1, SCHE 341/19-1, KR 3614/2-1)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amygdala, systemic inflammation, lipopolysaccharide, norepinephrine, c-fos, central amygdala, basolateral amygdala, cytokine gene expression, IL-1β, interleukin-6, TNF-α, anxiety-like behavior, locomotor activity, microdialysis, neuroimmune interactions
MeSH terms
Amygdala, Animals, Inflammation, Lipopolysaccharides, Male, Motor Activity, Neural Pathways, Neurons, Norepinephrine, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, Proto-Oncogene Proteins c-fos, Microdialysis, Rats, Interleukin-1beta

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