The effects of moderate exercise on chronic stress-induced intestinal barrier dysfunction and antimicrobial defense
Abstract
The purpose of this study was to examine the effect of moderate exercise on repeated restraint stress (RRS)-induced intestinal barrier dysfunction and explore possible mechanisms in a mouse model. Male Balb/c mice (6weeks) were randomized into 7 groups: CON functioned as controls with no intervention; RRS was subjected to 6h per day RRS for 7 consecutive days; RRS+SWIM received 30min per day of swimming prior to RRS; CON+SWIM only received 30min per day of swimming; and the other groups received one session of 30min swimming prior to sacrifice at 1-, 3- and 6h recovery. Intestinal permeability was quantified with FITC-dextran. Bacterial translocation was determined by quantification of bacterial colony forming units (CFUs) in cultured mesenteric lymph nodes (MLN), and with fluorescence in situ hybridization (FISH). Antimicrobial related gene expression at baseline and 1h after one session of 30min swimming was tested by quantitative real-time polymerase chain reaction (Q-PCR) in small intestinal segments. Protein expression of 5 genes with statistically significant increase was measured at baseline, and 1-, 3- and 6h post-swimming using enzyme-linked immunosorbent assay (ELISA). Thirty minutes per day of swimming before RRS attenuated bacterial translocations and maintained intestinal permeability. Gene expression and protein levels for four antimicrobial peptides (α-defensin 5, β-defensin 1, RegIIIβ and RegIIIγ) were significantly increased after one 30min swimming session. In conclusion, moderate exercise attenuated chronic stress-induced intestinal barrier dysfunction in mice, possibly due to augmentation of antimicrobial responses in the small intestine.
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Together these changes might help mitigate the effects of stress-induced intestinal barrier dysfunction.
“Together these changes might help mitigate the effects of stress-induced intestinal barrier dysfunction.”
From The athletic gut microbiota (2020) · cites this paper as [131]
Moderate endurance exercise in mice has been associated with lesser intestinal permeability, preservation of mucous thickness, lower rates of bacterial translocation, and up-regulated anti-microbial protein production and gene expression in small intestinal tissue.
“Moderate endurance exercise in mice has been associated with a lesser degree of intestinal permeability, preservation of mucous thickness, and lower rates of bacterial translocation along with up-regulated anti-microbial protein production and gene expression in small intestinal tissue (α-defensin, β-defensin, Reg IIIb and Reg IIIc) [131].”
From The athletic gut microbiota (2020) · cites this paper as [131]
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TITLE: Exercise and the microbiota
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- Authors
- Luo, B., Xiang, D., Nieman, D. C., & Chen, P.
- Affiliations
- Shanghai University of Sport (CN)
- Second Military Medical University (CN)
- Appalachian State University (US)
- Corresponding author
- Chen, Peijie
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 39
- Pages
- 99-106
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W1993365569
- Cited by
- 74
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanghai University of Sport
- Shanghai Municipal Education Commission
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- moderate-intensity exercise, swimming training, chronic stress, restraint stress, intestinal barrier dysfunction, intestinal permeability, bacterial translocation, antimicrobial peptides, alpha-defensin 5, beta-defensin 1, small intestine, mesenteric lymph nodes, stress recovery
- MeSH terms
- Animals, Intestinal Mucosa, Intestines, Male, Mice, Inbred BALB C, Permeability, Physical Conditioning, Animal, Restraint, Physical, Stress, Psychological, Swimming, Gene Expression, Bacterial Physiological Phenomena, Antimicrobial Cationic Peptides, Mice
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