Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella, Roberto; Luzi, Livio; Terruzzi, Ileana

doi:10.1016/j.dld.2017.11.016

Cited by 158Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases

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Codella, Roberto, Luzi, Livio, Terruzzi, Ileana·2018·Digestive and Liver Disease

DOI 10.1016/j.dld.2017.11.016

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Abstract

Limited animal and human research findings suggests that exercise might have a beneficial role for health gut. Cardiorespiratory fitness correlates with health-associated gut parameters such as taxonomic diversity and richness. Physical exercise may augment intestinal microbial diversity through several mechanisms including promotion of an anti-inflammatory state. Disease-associated microbial functions were linked to distinct taxa in previous studies of familial type 1 diabetes mellitus (T1D). An integrated multi-approach in the study of T1D, including physical exercise, is advocated. The present review explores how exercise might modulate gut microbiota and microbiome characteristics in chronic and immune-based diseases, given the demonstrated relationship between gut function and human health.

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Psychological stress, physical activity, tobacco use, alcohol consumption, and antibiotic exposure are modifying factors for the gut microbiome.
“Other modifying factors (Figure 1) include psychological stress33,34, physical activity35, tobacco use36, alcohol consumption37, and antibiotic exposure38, 39,40.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [35]

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Authors: Codella, R., Luzi, L., & Terruzzi, I.
Affiliations: University of Milan (IT)
IRCCS Ospedale San Raffaele (IT)
Corresponding author: Codella, Roberto
ORCID: Codella, Roberto
Luzi, Livio
Terruzzi, Ileana
Venue: Digestive and Liver Disease
Publisher: Elsevier BV
Published: 2018-04
Volume: 50
Issue: 4
Pages: 331-341
ISSN: 1590-8658 (ISSN-L)
DOI: 10.1016/j.dld.2017.11.016
OpenAlex: W2768098416
Cited by: 158
References: 130
Citations by year: 2026: 7 · 2025: 15 · 2024: 9 · 2023: 22 · 2022: 27 · 2021: 34 · 2020: 25 · 2019: 13 · 2018: 6
FWCI: 1.13
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Digestive and Liver Disease (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: physical activity, gut microbiota, cardiorespiratory fitness, microbial diversity, anti-inflammatory activity, type 1 diabetes, chronic disease, microbiome
MeSH terms: Gastrointestinal Microbiome, Animals, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Exercise, Gastrointestinal Tract, Mice, Rats

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Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases

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