Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
Open accessAbstract
Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of prion disease we applied gain- or loss-of CSF1R function, as means to stimulate or inhibit microglial proliferation, respectively, to dissect the contribution of these cells to neurogenesis. We found that increased hippocampal neurogenesis correlates with the expansion of the microglia population. The selective inhibition of microglial proliferation caused a reduction in neurogenesis and a restoration of normal neuronal differentiation, supporting a pro-neurogenic role for microglia. Using a gene screening strategy, we identified TGFβ as a molecule controlling the microglial pro-neurogenic response in chronic neurodegeneration, supported by loss-of-function mechanistic experiments. By the selective targeting of microglial proliferation we have been able to uncover a pro-neurogenic role for microglia in chronic neurodegeneration, suggesting promising therapeutic targets to normalise the neurogenic niche during neurodegeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microgliosis and astrocytosis were previously described in the dentate gyrus area of the hippocampus of prion disease mice.
“Microgliosis and astrocytosis were previously described in the dentate gyrus area of the hippocampus of prion disease mice [32, 38, 39].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [38]
The Results section reports significantly increased microglial density across the dentate gyrus in ME7 prion-diseased mice, supporting microgliosis there. The passages from our copy do not report astrocytosis in that area, so they support only part of the cited sentence. No page number is available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPharmacological modulation of microglia with GW2580 reduces neuronal population.
“pharmacological modulation of microglia with another CSF1R inhibitor, GW2580 was able to reduce neuronal population and aberrant neurogenesis and restore the normal neuronal differentiation [38].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [38]
The Results section reports that GW2580 prevented the expansion of DCX+ neuronal precursor cells in prion-diseased mice and restored baseline neurogenesis and normal neuronal differentiation. It does not establish a reduction in the overall neuronal population, as the claim states; the measured reduction concerns precursor cells. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCSF1R is not known to be expressed in neurons.
“However, CSF1R is not known to be expressed in neurons [38].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [38]
The Results report no evidence of CSF1R expression in neurons using the study’s reporter mice. But the Discussion acknowledges a recent report suggesting that CSF1R is expressed and functions in neurons, so the broader statement that neuronal expression is not known omits a qualification in the source. (LLM, conf=0.86)
Experimental — accuracy not yet measuredGW2580 reduces aberrant neurogenesis.
“pharmacological modulation of microglia with another CSF1R inhibitor, GW2580 was able to reduce neuronal population and aberrant neurogenesis and restore the normal neuronal differentiation [38].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [38]
GW2580 restores normal neuronal differentiation.
“pharmacological modulation of microglia with another CSF1R inhibitor, GW2580 was able to reduce neuronal population and aberrant neurogenesis and restore the normal neuronal differentiation [38].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Dendritic organization in the neurons of the visual and motor cortices of the cat.
Sholl, D. A. (1953) · Europe PMC (PubMed Central) · Cited by 2,204 · see citing works
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works
Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923 · see citing works
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Åberg, M. A. I., Åberg, N. D., Hedbäcker, H., Oscarsson, J., & Eriksson, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02896.2000 · Cited by 852 · see citing works
Brain inflammation and adult neurogenesis: The dual role of microglia
Ekdahl, C. T., Kokaia, Z., & Lindvall, O. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.052 · Cited by 801 · see citing works
Bett, A. J., Haddara, W. M. R., PREVEC, L., & Graham, F. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8802 · Cited by 742 · see citing works
Turnover of resident microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., & Gordon, S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90500-2 · Cited by 709 · see citing works
Self-citationKreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood · doi:10.1182/blood-2002-02-0569 · Cited by 662 · see citing works
Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K., & Pollard, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026317 · Cited by 649 · see citing works
Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.016 · Cited by 480 · see citing works
Migration and differentiation of neural precursor cells can be directed by microglia
Aarum, J., Sandberg, K., Haeberlein, S. L. B., & Persson, M. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237050100 · Cited by 450 · see citing works
Serum insulin-like growth factor I regulates brain amyloid-β levels
Carro, E., Trejo, J. L., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm793 · Cited by 448 · see citing works
Serum insulin-like growth factor I regulates brain amyloid-β levels
Carro, E., Jl, T., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm1202-793 · Cited by 442 · see citing works
Regulation of Microglial Proliferation during Chronic Neurodegeneration
Gómez-Nicola, D., Fransen, N. L., Suzzi, S., & Perry, V. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4440-12.2013 · Cited by 407 · see citing works
Self-citationMicroglia instruct subventricular zone neurogenesis
Walton, N. M., Sutter, B. M., Laywell, E. D., Levkoff, L. H., Kearns, S. M., Marshall, G. P., Scheffler, B., & Steindler, D. A. (2006) · Glia · doi:10.1002/glia.20419 · Cited by 400 · see citing works
Microglial Dynamics and Role in the Healthy and Diseased Brain: A Paradigm of Functional Plasticity
Gomez-Nicola, D., & Perry, V. H. (2015) · The Neuroscientist · doi:10.1177/1073858414530512 · Cited by 340 · see citing works
Self-citationInjury-Induced Neurogenesis in the Adult Mammalian Brain
Parent, J. M. (2003) · The Neuroscientist · doi:10.1177/1073858403252680 · Cited by 339 · see citing works
TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE
FLANDERS, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00066-x · Cited by 310 · see citing works
Battista, D., Ferrari, C. C., Gage, F. H., & Pitossi, F. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04539.x · Cited by 306 · see citing works
Microglia in Health and Disease
Ransohoff, R. M., & Khoury, J. E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020560 · Cited by 303 · see citing works
Li, G., Bien-Ly, N., Andrews-Zwilling, Y., Xu, Q., Bernardo, A., Ring, K., Halabisky, B., Deng, C., Mahley, R. W., & Huang, Y. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.015 · Cited by 288 · see citing works
A systems approach to prion disease
Hwang, D., Lee, I. Y., Yoo, H., Gehlenborg, N., Cho, J., Petritis, B., Baxter, D., Pitstick, R., Young, R., Spicer, D., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.10 · Cited by 287 · see citing works
Luo, J., Elwood, F., Britschgi, M., Villeda, S., Zhang, H., Ding, Z., Zhu, L., Alabsi, H., Getachew, R., Narasimhan, R., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20120412 · Cited by 262 · see citing works
Sendtner, M., Carrol, P., Holtmann, B., Hughes, R. A., & Thoenen, H. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251110 · Cited by 253 · see citing works
Sun, B., Halabisky, B., Zhou, Y., Palop, J. J., Yu, G., Mucke, L., & Gan, L. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.003 · Cited by 205 · see citing works
Valero, J., Mastrella, G., Neiva, I., Sánchez, S., & Malva, J. O. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00083 · Cited by 179 · see citing works
Transforming Growth Factor-β1 Is a Negative Modulator of Adult Neurogenesis
Wachs, F., Winner, B., Couillard‐Després, S., Schiller, T., Aigner, R., Winkler, J., Bogdahn, U., & Aigner, L. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000218444.53405.f0 · Cited by 174 · see citing works
Regulation of microglial activation by TGF-β, IL-10, and CSF-1
Lodge, P. A., & Sriram, S. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.60.4.502 · Cited by 156 · see citing works
Inflammation Regulates Functional Integration of Neurons Born in Adult Brain
Jakubs, K., Bonde, S., Iosif, R. E., Ekdahl, C. T., Kokaia, Z., Kokaia, M., & Lindvall, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3240-08.2008 · Cited by 148 · see citing works
Kempermann, G., & Neumann, H. (2003) · Science · doi:10.1126/science.1092864 · Cited by 139 · see citing works
Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration
Lunnon, K., Teeling, J. L., Tutt, A. L., Cragg, M. S., Glennie, M. J., & Perry, V. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0903833 · Cited by 138 · see citing works
Self-citationLlorens-Martı́n, M., Fuster-Matanzo, A., Teixeira, C. M., Jurado‐Arjona, J., Ulloa, F., DeFelipe, J., Rábano, A., Hernández, F., Soriano, E., & Ávila, J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.4 · Cited by 133 · see citing works
Innate and adaptive immune responses in neurodegeneration and repair
Amor, S., & Woodroofe, M. (2014) · Immunology · doi:10.1111/imm.12134 · Cited by 128 · see citing works
Kokjohn, T. A., & Roher, A. E. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.03.002 · Cited by 122 · see citing works
Neurotrophic factor control of adult SVZ neurogenesis
Bath, K. G., & Lee, F. S. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20781 · Cited by 105 · see citing works
ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis
He, Y., Zhang, H., Yung, A. R., Villeda, S., Jaeger, P. A., Olayiwola, O., Fainberg, N. A., & Wyss‐Coray, T. (2014) · Nature Neuroscience · doi:10.1038/nn.3732 · Cited by 102 · see citing works
Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions
Sabo, J. K., Aumann, T. D., Merlo, D., Kilpatrick, T. J., & Cate, H. S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5859-10.2011 · Cited by 93 · see citing works
TGFβ1 regulates the inflammatory response during chronic neurodegeneration
Boche, D., Cunningham, C. M., Docagne, F., Scott, H., & Perry, V. H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.004 · Cited by 89 · see citing works
Self-citationMüller, S., Chakrapani, P. S. B., Schwegler, H., Hofmann, H., & Kirsch, M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0234 · Cited by 88 · see citing works
Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration
Gomez-Nicola, D., Suzzi, S., Vargas-Caballero, M., Fransen, N. L., Al-Malki, H., Cebrian-Silla, A., Garcia-Verdugo, J. M., Riecken, K., Fehse, B., & Perry, V. H. (2014) · Brain · doi:10.1093/brain/awu155 · Cited by 84 · see citing works
Self-citationChronic Expression of Transforming Growth Factor-Beta Enhances Adult Neurogenesis
Mathieu, P., Piantanida, A. P., & Pitossi, F. J. (2010) · NeuroImmunoModulation · doi:10.1159/000258723 · Cited by 83 · see citing works
Kohman, R. A., Bhattacharya, T. K., Kilby, C. N., Bucko, P. J., & Rhodes, J. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.032 · Cited by 79 · see citing works
Adenovirus-mediated decorin gene transfer prevents TGF-β-induced inhibition of lung morphogenesis
Zhao, J., Sime, P. J., Bringas, P., Gauldie, J., & Warburton, D. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.2.l412 · Cited by 74 · see citing works
Fujioka, H., & Akema, T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.032 · Cited by 67 · see citing works
Gómez‐Nicola, D., Schetters, S. T. T., & Perry, V. H. (2014) · Glia · doi:10.1002/glia.22660 · Cited by 59 · see citing works
Self-citationIn-vivo RGB marking and multicolour single-cell tracking in the adult brain
Gómez‐Nicola, D., Riecken, K., Fehse, B., & Perry, V. H. (2014) · Scientific Reports · doi:10.1038/srep07520 · Cited by 47 · see citing works
Self-citationZen, A. A. H., Lafont, A. M., Durand, É., Brasselet, C., Lemarchand, P., Godeau, G., & Gogly, B. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00018-0 · Cited by 47 · see citing works
Kane, C. J. M., Brown, G. J., & Phelan, K. D. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00092-2 · Cited by 33 · see citing works
Gehlenborg, N., Hwang, D., Lee, I. Y., Yoo, H., Baxter, D. H., Petritis, B. O., Pitstick, R., Marzolf, B., DeArmond, S. J., Carlson, G. A., et al. (2009) · Database · doi:10.1093/database/bap011 · Cited by 21 · see citing works
Gómez‐Nicola, D., & Perry, V. H. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_18 · Cited by 13 · see citing works
Self-citationHow can we exploit the brain’s ability to repair itself?
Miller, V., & Gómez‐Nicola, D. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.985659 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
Askew, K., Li, K., Olmos-Alonso, A., Garcia-Moreno, F., Liang, Y., Richardson, P., Tipton, T., Chapman, M. A., Riecken, K., Beccari, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.041 · Cited by 726 · see citing works
Self-citationDevelopment of a Chimeric Model to Study and Manipulate Human Microglia In Vivo
Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.002 · Cited by 380 · see citing works
To Kill a Microglia: A Case for CSF1R Inhibitors
Green, K. N., Crapser, J. D., & Hohsfield, L. A. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.001 · Cited by 259 · see citing works
Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions
Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256 · see citing works
Infectious immunity in the central nervous system and brain function
Klein, R. S., Garber, C., & Howard, N. (2017) · Nature Immunology · doi:10.1038/ni.3656 · Cited by 235 · see citing works
Inflammatory Mediators and Pain in Endometriosis: A Systematic Review
Machairiotis, N., Vasilakaki, S., & Thomakos, N. (2021) · Biomedicines · doi:10.3390/biomedicines9010054 · Cited by 170 · see citing works
The P2X7 Receptor: Central Hub of Brain Diseases
Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works
Born this way: Hippocampal neurogenesis across the lifespan
Kozareva, D. A., Cryan, J. F., & Nolan, Y. M. (2019) · Aging Cell · doi:10.1111/acel.13007 · Cited by 146 · see citing works
Lannes, N., Eppler, E., Etemad, S., Yotovski, P., & Filgueira, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23106 · Cited by 139 · see citing works
Phenotypic clustering: a novel method for microglial morphology analysis
Verdonk, F., Roux, P., Flamant, P., Fiette, L., Bozza, F. A., Simard, S., Lemaire, M., Plaud, B., Shorte, S. L., Sharshar, T., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0614-7 · Cited by 132 · see citing works
Gerber, Y. N., Saint-Martin, G., Bringuier, C. M., Bartolami, S., Goze‐Bac, C., Noristani, H. N., & Perrin, F. E. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00368 · Cited by 117 · see citing works
Grabert, K., Sehgal, A., Irvine, K. M., Wollscheid-Lengeling, E., Ozdemir, D. D., Stables, J., Luke, G. A., Ryan, M. D., Adamson, A., Humphreys, N. E., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000835 · Cited by 114 · see citing works
Cellular and molecular pathophysiology in the progression of Parkinson’s disease
Zaman, V., Shields, D. C., Shams, R., Drasites, K. P., Matzelle, D. D., Haque, A., & Banik, N. L. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00689-5 · Cited by 115 · see citing works
Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
Hu, B., Duan, S., Wang, Z., Li, X., Zhou, Y., Zhang, X., Zhang, Y., Xu, H., & Zheng, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.789834 · Cited by 105 · see citing works
New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective
Pósfai, B., Cserép, C., Orsolits, B., & Dénes, Á. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.046 · Cited by 98 · see citing works
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
Chadarevian, J. P., Lombroso, S. I., Peet, G. C., Hasselmann, J., Tu, C. H., Marzan, D. E., Capocchi, J. K., Purnell, F. S., Nemec, K. M., Lahian, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220857 · Cited by 99 · see citing works
The emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works
Indulekha, K., Alam, S., Surendar, J., Frohberger, S. J., Hansen, J. N., Kuehlwein, J. M., Hölbling, B. V., Schumak, B., Hübner, M. P., Gräler, M. H., et al. (2019) · Glia · doi:10.1002/glia.23663 · Cited by 89 · see citing works
Jiang, X., Yi, S., Liu, Q., Su, D., Li, L., Xiao, C., & Zhang, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02478-y · Cited by 89 · see citing works
High-Fat Diet-Induced Obesity Causes Sex-Specific Deficits in Adult Hippocampal Neurogenesis in Mice
Robison, L. S., Albert, N. M., Camargo, L. A., Anderson, B. M., Salinero, A. E., Riccio, D. A., Abi‐Ghanem, C., Gannon, O. J., & Zuloaga, K. L. (2019) · eNeuro · doi:10.1523/eneuro.0391-19.2019 · Cited by 83 · see citing works
Microglia as Therapeutic Target for Radiation-Induced Brain Injury
Liu, Q., Yan, H., Duan, M., Yang, Q., Ren, B., & Tang, F. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158286 · Cited by 83 · see citing works
Gray, S. C., Kinghorn, K. J., & Woodling, N. S. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.272571 · Cited by 73 · see citing works
Microglial control of neuronal development via somatic purinergic junctions
Cserép, C., Schwarcz, A. D., Pósfai, B., László, Z. I., Kellermayer, A., Környei, Z., Kisfali, M., Nyerges, M., Lele, Z., Katona, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111369 · Cited by 67 · see citing works
Hare, D. J., Raven, E. P., Roberts, B. R., Bogeski, M., Portbury, S. D., McLean, C., Masters, C. L., Connor, J. R., Bush, A. I., Crouch, P. J., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.05.057 · Cited by 68 · see citing works
Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G. E., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J., & Coleman, P. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.019 · Cited by 65 · see citing works
Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases
D’Argenio, V., & Sarnataro, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194704 · Cited by 61 · see citing works
Poulen, G., Aloy, E., Bringuier, C. M., Mestre‐Francés, N., Artus, E. V. F., Cardoso, M., Perez, J., Goze‐Bac, C., Boukhaddaoui, H., Lonjon, N., et al. (2021) · Theranostics · doi:10.7150/thno.61833 · Cited by 60 · see citing works
Schartz, N. D., Liang, H. Y., Carvalho, K., Chu, S., Mendoza‐Arvilla, A., Petrisko, T. J., Gómez-Arboledas, Á., Mortazavi, A., & Tenner, A. J. (2024) · Nature Communications · doi:10.1038/s41467-024-51163-6 · Cited by 64 · see citing works
Fatty Acid Synthesis in Glial Cells of the CNS
Corrales, A. V. G., Haidar, M., Bogie, J. F. J., & Hendriks, J. J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158159 · Cited by 57 · see citing works
Glucocorticoids as Regulators of Macrophage-Mediated Tissue Homeostasis
Díaz-Jiménez, D., Kolb, J. P., & Cidlowski, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669891 · Cited by 55 · see citing works
Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration
Al‐Onaizi, M., Al-Khalifah, A., Qasem, D., & ElAli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186875 · Cited by 53 · see citing works
Faust, A. E., Kandakatla, A., van der Merwe, Y., Ren, T., Huleihel, L., Hussey, G. S., Naranjo, J. D., Johnson, S. A., Badylak, S. F., & Steketee, M. B. (2017) · Journal of Biomaterials Applications · doi:10.1177/0885328217698062 · Cited by 50 · see citing works
Wilkins, H., Koppel, S. J., Weidling, I. W., Roy, N., Ryan, L. N., Stanford, J. A., & Swerdlow, R. H. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9704-7 · Cited by 49 · see citing works
Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis
Stefani, J., Tschesnokowa, O., Parrilla, M., Robaye, B., Boeynaems, J. M., Acker‐Palmer, A., Zimmermann, H., & Gampe, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00134 · Cited by 48 · see citing works
FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism
Criado‐Marrero, M., Smith, T. M., Gould, L. A., Kim, S., Penny, H. J., Sun, Z., Gulick, D., Dickey, C. A., & Blair, L. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100143 · Cited by 42 · see citing works
Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 41 · see citing works
Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury
Navabi, S. P., Badreh, F., Shooshtari, M. K., Hajipour, S., Vastegani, S. M., & Khoshnam, S. E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35869 · Cited by 39 · see citing works
Carrier, M., Šimončičová, E., St‐Pierre, M., McKee, C., & Tremblay, M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.749737 · Cited by 37 · see citing works
Yao, X., Yang, C., Wang, C., Li, H., Zhao, J., Kang, X., Liu, Z., Chen, L., Chen, X., Pu, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158316 · Cited by 38 · see citing works
An overview of microglia ontogeny and maturation in the homeostatic and pathological brain
Mendes, M. S., & Majewska, A. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15225 · Cited by 35 · see citing works
Identifying molecular mediators of environmentally enhanced neurogenesis
Eisinger, B. E., & Zhao, X. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2718-5 · Cited by 34 · see citing works
Park, B.-K., Kim, Y. H., Kim, Y. R., Choi, J. J., Yang, C., Jang, I., & Lee, M. Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/7585896 · Cited by 33 · see citing works
Yadav, A., Tandon, A., Seth, B., Goyal, S., Singh, S. J., Tiwari, S. K., Agarwal, S., Nair, S., & Chaturvedi, R. K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02108-9 · Cited by 32 · see citing works
Yang, F. Y., Shi, B., Liu, X., Luo, J., Rao, Z., Rong, L., & Zeng, N. (2020) · Neural Plasticity · doi:10.1155/2020/8841332 · Cited by 31 · see citing works
Let’s make microglia great again in neurodegenerative disorders
Guillot‐Sestier, M., & Town, T. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1792-x · Cited by 26 · see citing works
Steroid hormones: risk and resilience in women’s Alzheimer disease
Calvo, N., & Einstein, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1159435 · Cited by 26 · see citing works
CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis
Muzio, L., & Perego, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094865 · Cited by 26 · see citing works
Honig, M. G., Dorian, C. C., Worthen, J. D., Micetich, A. C., Mulder, I. A., Sanchez, K. B., Pierce, W. F., Mar, N. A. D., & Reiner, A. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14711 · Cited by 24 · see citing works
Cai, Q., Li, Y., Mao, J., & Pei, G. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00280 · Cited by 23 · see citing works
The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis
Mabbott, N. A., Bradford, B. M., Pal, R., Young, R. A., & Donaldson, D. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197299 · Cited by 20 · see citing works
Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease
Vidovic, N., & Spittau, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063090 · Cited by 21 · see citing works
Prion disease pathogenesis in the absence of the commensal microbiota
Bradford, B. M., Tetlow, L., & Mabbott, N. A. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000860 · Cited by 18 · see citing works
Neuroprotective and Anti—Neuroinflammatory Effects of a Poisonous Plant Croton tiglium Linn. Extract
Gupta, D. P., Park, S. H., Yang, H., Suk, K., & Song, G. J. (2020) · Toxins · doi:10.3390/toxins12040261 · Cited by 18 · see citing works
Giacobbe, J., Pariante, C. M., & Borsini, A. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120936538 · Cited by 19 · see citing works
Vicente-Rodríguez, M., Mancuso, R., Peris-Yague, A., Simmons, C., NIMA Consortium, Wlazly, D., Dickinson, A., Foster, A., Knight, C., Leckey, C., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02769-y · Cited by 17 · see citing works
“Microgliosis and astrocytosis were previously described in the dentate gyrus area of the hippocampus of prion disease mice [32, 38, 39].”
BackgroundResultInfluentialIntranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease
Hay, A. J. D., Latham, A. S., Mumford, G., Hines, A. D., Risen, S. J., Gordon, E., Siebenaler, C., Gilberto, V. S., Zabel, M. D., & Moreno, J. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1158408 · Cited by 17 · see citing works
The role of the immune system in prion infection
Mabbott, N. A., Alibhai, J. D., & Manson, J. C. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63945-5.00005-2 · Cited by 17 · see citing works
Microglia, synaptic dynamics and forgetting
Wang, C., Wang, L., & Gu, Y. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.005 · Cited by 18 · see citing works
The influence of the commensal and pathogenic gut microbiota on prion disease pathogenesis
Donaldson, D. S., & Mabbott, N. A. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000507 · Cited by 16 · see citing works
Hoeijmakers, L., Amelianchik, A., Verhaag, F., Kotah, J. M., Lucassen, P. J., & Kőrösi, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00061 · Cited by 16 · see citing works
Zeller, M. V., Sebastião, A. M., & Valente, C. A. (2022) · Biomolecules · doi:10.3390/biom12050666 · Cited by 14 · see citing works
Microglia, physiology and behavior: A brief commentary
Walker, F. R., & Yirmiya, R. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.006 · Cited by 14 · see citing works
Immunology of Prion Protein and Prions
Mabbott, N. A. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.06.004 · Cited by 539 · see citing works
Manganese induces neuroinflammation via NF-κB/ROS NLRP3 pathway in rat brain striatum and HAPI cells
Zhao, X., Yin, L., Wu, Y., Han, M., Zhuang, Y., Cong, Y., Liu, Y., Chen, G., & Jiang, J. (2019) · Molecular & Cellular Toxicology · doi:10.1007/s13273-019-0021-0 · Cited by 13 · see citing works
Enhanced Cognition and Neurogenesis in miR-146b Deficient Mice
Chithanathan, K., Somelar, K., Jürgenson, M., Žarkovskaja, T., Periyasamy, K., Yan, L., Magilnick, N., Boldin, M., Rebane, A., Tian, L., et al. (2022) · Cells · doi:10.3390/cells11132002 · Cited by 14 · see citing works
Epigenetic Regulation of the Hippocampus, with Special Reference to Radiation Exposure
Saw, G., & Tang, F. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249514 · Cited by 12 · see citing works
Li, Q., Li, H., Yao, X., Wang, C., Liu, H., Xu, D., Yang, C., Zhuang, H., Xiao, Y. M., Liu, R., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.749925 · Cited by 13 · see citing works
Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice
Britton, R., Liu, A. T., Rege, S. V., Adams, J. M., Akrapongpisak, L., Le, D., Alcantara‐Lee, R., Estrada, R. A., Ray, R. D., Ahadi, S., et al. (2022) · Brain and Behavior · doi:10.1002/brb3.2736 · Cited by 12 · see citing works
Neurogenesis and Neuroinflammation in Dialogue: Mapping Gaps, Modulating Microglia, Rewiring Aging
Tanaka, M. (2026) · Cells · doi:10.3390/cells15010078 · Cited by 11 · see citing works
Peng, X., Yang, Z., Guo, H.-S., Wu, X., Ruganzu, J. B., Liu, Z., Wu, S., & Yang, W. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05449-5 · Cited by 11 · see citing works
Hay, A. J. D., Popichak, K. A., Mumford, G., Shirley, P. M., Bian, J., Wolfrath, L., Lei, S., Eggers, M., Nicholson, E. M., Tjalkens, R. B., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012582 · Cited by 10 · see citing works
Effects of Higher Normal Blood Pressure on Brain Are Detectable before Middle-Age and Differ by Sex
Alateeq, K., Walsh, E., Abhayaratna, W. P., & Cherbuin, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113127 · Cited by 9 · see citing works
Overview of peripheral and central inflammatory responses and their contribution to neurotoxicity
Filipov, N. M. (2018) · Advances in neurotoxicology · doi:10.1016/bs.ant.2018.10.001 · Cited by 9 · see citing works
CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation
Perez, J., Poulen, G., Cardoso, M., Boukhaddaoui, H., Gazard, C., Courtand, G., Bertrand, S. S., Gerber, Y. N., & Perrin, F. E. (2023) · Glia · doi:10.1002/glia.24451 · Cited by 8 · see citing works
Impaired response to sleep deprivation in heterozygous Disc1 mutant mice
Tsao, C.-Y., Tuan, L., Lee, L. J., Liu, C., Hwu, H., & Lee, L. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1907724 · Cited by 8 · see citing works
Hoeijmakers, L., Meerhoff, G., de Vries, J. W., Ruigrok, S., van Dam, A., Leuven, F. V., Korosi, A., & Lucassen, P. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.013 · Cited by 13 · see citing works
In Situ Temporospatial Characterization of the Glial Response to Prion Infection
Michael, A. V., Greenlee, J. J., Harm, T. A., Moore, S. J., Zhang, M., Lind, M. S., Greenlee, M. H. W., & Smith, J. D. (2019) · Veterinary Pathology · doi:10.1177/0300985819861708 · Cited by 6 · see citing works
Lorenzen, K. A., Mathy, N. W., Whiteford, E. R., Eischeid, A. N., Chen, J., Behrens, M., Chen, X., & Shibata, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-020-06092-0 · Cited by 6 · see citing works
Borjini, N., Fernández, M., Giardino, L., Sorokin, L. M., & Calzà, L. (2025) · Cells · doi:10.3390/cells14060414 · Cited by 5 · see citing works
The Role of Glial Cells in Neurobiology and Prion Neuropathology
Hay, A. J. D., Popichak, K. A., Moreno, J. A., & Zabel, M. D. (2024) · Cells · doi:10.3390/cells13100832 · Cited by 5 · see citing works
Felice, E. D., Bobotis, B. C., Rigillo, G., Khakpour, M., de Andrade, E. G., Benatti, C., Vilella, A., Tascedda, F., Limatola, C., Tremblay, M., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.11.034 · Cited by 5 · see citing works
Piccardo, P., & Asher, D. M. (2018) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20180111 · Cited by 5 · see citing works
Hippocampal Microglia Activation Induced by Acute Pancreatic Injury in Rats
Cabral-França, T., Cruz, F. F., Silva, P. C., Pannain, V. L., Fernandes, A., Eulálio, J. M. R., Paiva, M. M., Ramos, H. M., Manso, J. E. F., & Baetas‐da‐Cruz, W. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08167-x · Cited by 5 · see citing works
Ma, Y., Lee, H., Chan, K., Eskandarian, L., Gaudet, K., Tian, Q., Bhatt, A., Gerold, J., Russo, A. W., Salat, D. H., et al. (2025) · Aging Cell · doi:10.1111/acel.70274 · Cited by 5 · see citing works
Godeanu, S., Mușat, M. I., Scheller, A., Osiac, E., & Cătălin, B. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1507140 · Cited by 4 · see citing works
Schartz, N. D., Liang, H. Y., Carvalho, K., Chu, S., Mendoza‐Arvilla, A., Petrisko, T. J., Gómez-Arboledas, Á., Mortazavi, A., & Tenner, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.22.554306 · Cited by 4 · see citing works
Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography
Tahmasian, N., Feng, M. Y., Arbabi, K., Rusu, B., Cao, W., Kukreja, B., Lubotzky, A., Wainberg, M., Tripathy, S. J., & Kalish, B. T. (2024) · eNeuro · doi:10.1523/eneuro.0224-24.2024 · Cited by 3 · see citing works
Versatile use of rtTA-expressing retroviruses in the study of neurodegeneration
Teixeira, C. M., Ávila, J., & Llorens-Martı́n, M. (2016) · Oncotarget · doi:10.18632/oncotarget.14386 · Cited by 3 · see citing works
Functional Analysis of a Novel Immortalized Murine Microglia Cell Line in 3D Spheroid Model
Angst, G., Tang, X., & Wang, C. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03952-6 · Cited by 3 · see citing works
Contactomics of Microglia and Intercellular Communication
Cserép, C., Pósfai, B., Szabadits, E., & Dénes, Á. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_8 · Cited by 1 · see citing works
Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular BiogeographyPreprint
Tahmasian, N., Feng, M. Y., Arbabi, K., Rusu, B., Cao, W., Kukreja, B., Lubotzky, A., Wainberg, M., Tripathy, S. J., & Kalish, B. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.25.581974 · Cited by 1 · see citing works
Reactive Neurogenesis in the Forebrain of the Leopard Gecko
Austin, L. E. (2020) · The Atrium (University of Guelph)
Microglia induce neurogenesis by stimulating PI3K/AKT intracellular signaling in vitroPreprint
Lorenzen, K. A., Mathy, N. W., Whiteford, E. R., Eischeid, A. N., Chen, J., Behrens, M., Chen, X., & Shibata, A. (2019) · doi:10.21203/rs.2.11343/v1
Somatic junctions connect microglia and developing neuronsPreprint
Cserép, C., Schwarcz, A. D., Pósfai, B., László, Z. I., Kellermayer, A., Nyerges, M., Lele, Z., Katona, I., & Dénes, Á. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.25.436920
Microglia induce neurogenesis by stimulating PI3K/AKT intracellular signaling in vitroPreprint
Lorenzen, K. A., Mathy, N. W., Whiteford, E. R., Eischeid, A. N., Chen, J., Behrens, M., Chen, X., & Shibata, A. (2020) · doi:10.21203/rs.2.11343/v3
Microglia induce neurogenesis by stimulating PI3K/AKT intracellular signaling in vitroPreprint
Lorenzen, K. A., Mathy, N. W., Whiteford, E. R., Eischeid, A. N., Chen, J., Behrens, M., Chen, X., & Shibata, A. (2019) · doi:10.21203/rs.2.11343/v2
Kukuia, K. K. E., Takyi, F. Y., Dugbartey, G. J., Amoateng, P., Kudzi, W., Amponsah, S. K., Koomson, A. E., Appiah, F., Adi‐Dako, O., Ameyaw, E. O., et al. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17508.1
Microglia activation induced by a rat model of mild acute pancreatitisPreprint
Cabral-França, T., Cruz, F. F., Silva, P. C., Pannain, V. L., Fernandes, A., Eulálio, J. M. R., Paiva, M. M., Ramos, H. M., Manso, J. E. F., & Baetas‐da‐Cruz, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3083187/v1
Kukuia, K. K. E., Takyi, F. Y., Dugbartey, G. J., Amoateng, P., Kudzi, W., Amponsah, S. K., Koomson, A. E., Appiah, F., Adi‐Dako, O., Ameyaw, E. O., et al. (2024) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17508.2
Shtrahman, M., Parylak, S., Toda, T., & Gage, F. H. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0009
- Authors
- De Lucia, C., Rinchon, A., Olmos-Alonso, A., Riecken, K., Fehse, B., Boche, D., Perry, V. H., & Gomez-Nicola, D.
- Affiliations
- University of Southampton (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 55
- Pages
- 179-190
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4907582
- OpenAlex
- W2119211366
- Cited by
- 110
- References
- 58
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 8
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- ORBi UMONS (submittedVersion)
- Funders
- Wessex Medical Research
- Medical Research Council (MR/K022687/1)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, hippocampal neurogenesis, chronic neurodegeneration, prion disease, CSF1R, microglial proliferation, TGF-beta, neuronal differentiation, neurogenic niche, neuroinflammation, innate immunity
- MeSH terms
- Animals, Disease Models, Animal, Hippocampus, Mice, Inbred C57BL, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Transforming Growth Factor beta, Prion Diseases, Microglia, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
