Cited by 214Gut microbiota and healthAutism Spectrum Disorder ResearchProbiotics and Fermented Foods

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Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders

Tabouy, Laure, Getselter, Dimitry, Ziv, Oren, Karpuj, Marcela, Tabouy, Timothée, Lukic, Iva, Maayouf, Rasha, Werbner, Nir, Ben-Amram, Hila, Nuriel-Ohayon, Meital, Koren, Omry, Elliott, Evan·2018·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2018.05.015

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Abstract

Recent studies have determined that the microbiome has direct effects on behavior, and may be dysregulated in neurodevelopmental conditions. Considering that neurodevelopmental conditions, such as autism, have a strong genetic etiology, it is necessary to understand if genes associated with neurodevelopmental disorders, such as Shank3, can influence the gut microbiome, and if probiotics can be a therapeutic tool. In this study, we have identified dysregulation of several genera and species of bacteria in the gut and colon of both male and female Shank3 KO mice. L. reuteri, a species with decreased relative abundance in the Shank3 KO mice, positively correlated with the expression of gamma-Aminobutyric acid (GABA) receptor subunits in the brain. Treatment of Shank3 KO mice with L. reuteri induced an attenuation of unsocial behavior specifically in male Shank3 mice, and a decrease in repetitive behaviors in both male and female Shank3 KO mice. In addition, L. reuteri treatment affected GABA receptor gene expression and protein levels in multiple brain regions. This study identifies bacterial species that are sensitive to an autism-related mutation, and further suggests a therapeutic potential for probiotic treatment.

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Authors: Tabouy, L., Getselter, D., Ziv, O., Karpuj, M., Tabouy, T., Lukic, I., Maayouf, R., Werbner, N., Ben-Amram, H., Nuriel-Ohayon, M., Koren, O., & Elliott, E.
Affiliations: Bar-Ilan University (IL)
AgroParisTech (FR)
Corresponding author: Elliott, Evan
ORCID: Karpuj, Marcela
Tabouy, Timothée
Koren, Omry
Elliott, Evan
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2018-10
Volume: 73
Pages: 310-319
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2018.05.015
OpenAlex: W2803873435
Cited by: 214
References: 67
Citations by year: 2026: 17 · 2025: 33 · 2024: 37 · 2023: 31 · 2022: 28 · 2021: 25 · 2020: 22 · 2019: 16 · 2018: 5
FWCI: 6.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: autism spectrum disorder, gut dysbiosis, probiotics, Shank3 knockout mice, Lactobacillus reuteri, repetitive behavior, sex differences, neurodevelopmental disorders
MeSH terms: Autism Spectrum Disorder, Gastrointestinal Microbiome, Animals, Behavior, Animal, Brain, Disease Models, Animal, Female, Male, Microfilament Proteins, Models, Genetic, Nerve Tissue Proteins, Receptors, GABA, Mice, Knockout, Probiotics, Mice, Limosilactobacillus reuteri, Dysbiosis

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Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders

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