The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat
Abstract
The present study investigated the effects of post-weaning social isolation (SI) on behavioural and neuroendocrine reactivity to stress of male and female rats. Innate aspects of fear and anxiety were assessed in the open field and elevated plus maze tests. Spontaneous startle reflex and conditioned fear response were further investigated. The neuroendocrine response of isolates was examined by measuring basal and stress release of ACTH and corticosterone and by evaluating the mRNA expression of mineralocorticoid (MR) and glucocorticoid (GR) receptors using in situ hybridization. Locomotor activity in the open field was not modified by chronic SI. In males, but not females, SI produced an anxiogenic profile in the elevated plus maze. Male isolates showed a trend towards increased startle reflex amplitude relative to socially-reared controls. Moreover, SI in males produced alterations of the HPA axis functioning as reflected by higher basal levels of ACTH, and enhanced release of ACTH and corticosterone following stress. In contrast, startle response or HPA axis functioning were not altered in female isolates. Social isolates from both genders showed reduced contextual fear-conditioning. Finally, the mRNA expression of MR and GR was not modified by SI. The results of the present study suggest that chronic SI increases emotional reactivity to stress and produces a hyperfunction of the HPA axis in adult rats, particularly in males.
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“As with maternal separation, post-weaning social isolation results in enhanced sensitivity of the HPA axis, especially in male rats (Holson et al., 1991; Viveros et al., 1988; Weiss et al., 2004), as well as an overall anxiogenic phenotype.”
From The effects of early life stress on reward processing (2018) · cites this paper as Weiss et al., 2004
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Cites
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Dietary Choices and Habits during COVID-19 Lockdown: Experience from Poland
Sidor, A., & Rzymski, P. (2020) · Nutrients · doi:10.3390/nu12061657 · Cited by 1,178
“long isolation results in increased stress levels [57], while stress is a well-established risk factor for”
BackgroundSources of stress in captivity
Morgan, K. N., & Tromborg, C. T. (2007) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2006.05.032 · Cited by 1,085
“Similar effects of social isolation on physiological and behavioral parameters associated with stress are found in rats (Genaro et al., 2004; Weiss et al., 2004) and cattle (Boissy and Le Neindre, 1997).”
BackgroundFone, K. C. F., & Porkess, M. V. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.003 · Cited by 864
Epigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812
Animal models of schizophrenia
Jones, C., Watson, D., & Fone, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01386.x · Cited by 771
“For instance, post-weaning social isolation of rodents induces spontaneous locomotor hyperactivity, enhanced responses to novelty (neophobia), sensorimotor gating deficits, cognitive impairments, and heightened anxiety states and aggression (Valzelli, 1973; Einon and Morgan, 1977; Heidbreder et al., 2000; Weiss et al.…”
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Metadata
- Authors
- Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I., & Feldon, J.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Feldon, Joram
- ORCID
- Pryce, Christopher R
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 152
- Issue
- 2
- Pages
- 279-295
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2076236287
- Cited by
- 512
- References
- 76
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 26 · 2023: 18 · 2022: 29 · 2021: 33 · 2020: 46 · 2019: 25 · 2018: 19 · 2017: 30 · 2016: 22 · 2015: 25 · 2014: 25 · 2013: 24 · 2012: 26
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Branco Weiss Fellowship – Society in Science
- Eidgenössische Technische Hochschule Zürich
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social isolation, post-weaning social isolation, stress reactivity, hypothalamic-pituitary-adrenal axis, ACTH, corticosterone, mineralocorticoid receptor, glucocorticoid receptor, anxiety, fear conditioning, startle response, sex differences, neuroendocrine response, rats
- MeSH terms
- Adrenocorticotropic Hormone, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Brain, Conditioning, Psychological, Corticosterone, Fear, Female, Glucocorticoids, Immunohistochemistry, Kidney, Male, Motor Activity, Neurosecretory Systems, Radioimmunoassay, Random Allocation, Reflex, Acoustic, Sex Factors, Social Isolation, Stress, Physiological, Weaning, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Mineralocorticoid, Maze Learning, Rats
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