Cited by 512Stress Responses and CortisolNeuroendocrine regulation and behaviorMemory and Neural Mechanisms

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Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat

Weiss, Isabelle C, Pryce, Christopher R, Jongen-Rêlo, Ana L, Nanz-Bahr, Nina I, Feldon, Joram·2004·Behavioural Brain Research

DOI 10.1016/j.bbr.2003.10.015

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Abstract

The present study investigated the effects of post-weaning social isolation (SI) on behavioural and neuroendocrine reactivity to stress of male and female rats. Innate aspects of fear and anxiety were assessed in the open field and elevated plus maze tests. Spontaneous startle reflex and conditioned fear response were further investigated. The neuroendocrine response of isolates was examined by measuring basal and stress release of ACTH and corticosterone and by evaluating the mRNA expression of mineralocorticoid (MR) and glucocorticoid (GR) receptors using in situ hybridization. Locomotor activity in the open field was not modified by chronic SI. In males, but not females, SI produced an anxiogenic profile in the elevated plus maze. Male isolates showed a trend towards increased startle reflex amplitude relative to socially-reared controls. Moreover, SI in males produced alterations of the HPA axis functioning as reflected by higher basal levels of ACTH, and enhanced release of ACTH and corticosterone following stress. In contrast, startle response or HPA axis functioning were not altered in female isolates. Social isolates from both genders showed reduced contextual fear-conditioning. Finally, the mRNA expression of MR and GR was not modified by SI. The results of the present study suggest that chronic SI increases emotional reactivity to stress and produces a hyperfunction of the HPA axis in adult rats, particularly in males.

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Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
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Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Tests for emotionality in rats and mice: A review
Archer, J. (1973) · Animal Behaviour · doi:10.1016/s0003-3472(73)80065-x · Cited by 1,577
Anxiety, defence and the elevated plus-maze.
Rodgers, R., & Dalvi, A. (1997) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00058-9 · Cited by 1,028
The serum transport of steroid hormones
SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770
Do early‐life events permanently alter behavioral and hormonal responses to stressors?
Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654
Variations in maternal care in infancy regulate the development of stress reactivity
Caldji, C., Diorio, J. C., & Meaney, M. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01084-2 · Cited by 588
Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
Selden, N. R. W., Everitt, B. J., Jarrard, L. E., & Robbins, T. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90379-3 · Cited by 578
Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences
Hall, F. S. (1998) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.50 · Cited by 512
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Goosens, K. A., & Maren, S. (2001) · Learning & Memory · doi:10.1101/lm.37601 · Cited by 451
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Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia
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Blanchard, R. J., Blanchard, D. C., Rodgers, J., & Weiss, S. Μ. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80069-7 · Cited by 366
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Dissociating context and space within the hippocampus: Effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning.
Richmond, M. A., Yee, B. K., Pouzet, B., Veenman, L., Rawlins, J. N. P., Feldon, J., & Bannerman, D. M. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.6.1189 · Cited by 332
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Wilkinson, L. S., Killcross, S., Humby, T., Hall, F. S., Geyer, M. A., & Robbins, T. W. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.8 · Cited by 268
Locomotor activity, defecation score and corticosterone levels during an openfield exposure: A comparison among individually and group-housed rats, and genetically selected rat lines
Gentsch, C., Lichtsteiner, M., & Feer, H. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90320-6 · Cited by 233
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Hatch, A., Wiberg, G., Balázs, T., & Grice, H. C. (1963) · Science · doi:10.1126/science.142.3591.507 · Cited by 228
A refined method for sequential blood sampling by tail incision in rats
Fluttert, M., Dalm, S., & Oitzl, M. S. (2000) · Laboratory Animals · doi:10.1258/002367700780387714 · Cited by 227
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Differential role of the medial and lateral prefrontal cortices in fear and anxiety.
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Isolation syndrome in the rat
Hatch, A., Wiberg, G., Zawidzka, Z., Cann, M. C., Airth, J. M., & Grice, H. C. (1965) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(65)90132-8 · Cited by 158
The interpretation of physiological correlates of differential housing in laboratory rats
Brain, P. F., & Benton, D. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90119-x · Cited by 156
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Parker, V., & Morinan, A. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90224-8 · Cited by 113
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Morgan, M. J., Einon, D. F., & Nicholas, D. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400524 · Cited by 97
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Weiss, I. C., Domeney, A. M., Moreau, J., Russig, H. D., & Feldon, J. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00166-8 · Cited by 91
A computer controlled analysis of freezing behaviour
Richmond, M. A., Murphy, C. A., Pouzet, B., Schmid, P., Rawlins, J. N. P., & Feldon, J. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00150-2 · Cited by 90
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Early handling and latent inhibition in the conditioned suppression paradigm
Weiner, I., Feldon, J., & Ziv‐Harris, D. (1987) · Developmental Psychobiology · doi:10.1002/dev.420200211 · Cited by 86
Different reaction patterns in individually and socially reared rats during exposures to novel environments
Gentsch, C., Lichtsteiner, M., Kräuchi, K., & Feer, H. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90163-2 · Cited by 84
Differential Startle Amplitude and Corticosterone Response in Rats
Glowa, J. R., Geyer, M. A., Gold, P. W., & Stemberg, E. M. (2008) · Neuroendocrinology · doi:10.1159/000126298 · Cited by 83
Environmental enrichment and deprivation: Effects on learning, memory and exploration
Gardner, E. B., Boitano, J. J., Mancino, N. S., D'Amico, D. P., & Gardner, E. L. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90040-2 · Cited by 77
The effects of pre- and postweaning rearing conditions on latent inhibition and partial reinforcement extinction effect in male rats
Feldon, J., Avnimelech-Gigus, N., & Weiner, I. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90407-w · Cited by 75
Inhibition and isolation rearing in the rat: Extinction and satiation
Morgan, M. K., Einon, D. F., & Morris, R. G. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90084-1 · Cited by 73
The Effects of Isolation-Rearing of Rats on Behavioural Responses to Food and Environmental Novelty
Hall, F. S., Humby, T., Wilkinson, L. S., & Robbins, T. W. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00115-7 · Cited by 73
Social isolation at weaning: Some effects on two measures of activity
Syme, L. A. (1973) · Animal Learning & Behavior · doi:10.3758/bf03199065 · Cited by 73
The development of intersession habituation and emergence in socially reared and isolated rats
Einon, D. F., Morgan, M. J., & Sahakian, B. J. (1975) · Developmental Psychobiology · doi:10.1002/dev.420080613 · Cited by 72
The Ontogeny of Glucocorticoid Negative Feedback: Influence of Maternal Deprivation1
van Oers, H. J. J., de Kloet, E. R., Li, C., & Levine, S. D. (1998) · Endocrinology · doi:10.1210/endo.139.6.6037 · Cited by 70
Isolation rearing-induced disruption of prepulse inhibition
Weiss, I. C., Feldon, J., & Domeney, A. M. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199903000-00003 · Cited by 69
The Effects of Isolation-Rearing on Preference by Rats for A Novel Environment
Hall, F. S., Humby, T., Wilkinson, L. S., & Robbins, T. W. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00117-0 · Cited by 66
Habituation of object contact in socially-reared and isolated rats (Rattus norvegicus)
Einon, D. F., & Morgan, M. J. (1976) · Animal Behaviour · doi:10.1016/s0003-3472(76)80051-6 · Cited by 66
Handling and Isolation in Three Strains of Rats Affect Open Field, Exploration, Hoarding and Predation
Rebouças, R. C. R., & Schmidek, W. R. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00312-0 · Cited by 61
Long-Term Effects of Repeated Maternal Separation on Three Different Latent Inhibition Paradigms
Lehmann, J., Stöhr, T., Schuller, J., Domeney, A. M., Heidbreder, C. A., & Feldon, J. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00529-7 · Cited by 51
Neuroendocrine and Immunocytochemical Demonstrations of Decreased Hypothalamo-Pituitary-Adrenal Axis Responsiveness to Restraint Stress after Long-Term Social Isolation
Sanchez, M. M. (1998) · Endocrinology · doi:10.1210/en.139.2.579 · Cited by 46
Adrenocortical, β-endorphin and behavioral responses to graded stressors in differentially reared rats
Holson, R. R., Scallet, A. C., Ali, S. F., Sullivan, P. A., & Gough, B. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90286-7 · Cited by 43
At issue: stress, hippocampal neuronal turnover, and neuropsychiatric disorders
Arango, C., Kirkpatrick, B., & Koenig, J. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006888 · Cited by 43
Some anatomical and physiological correlates of social isolation in the young rat
Morinan, A., & Leonard, B. E. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90265-6 · Cited by 40
Pre-weaning non-handling of rats disrupts latent inhibition in males, and results in persisting sex-and area-dependent increases in dopamine and serotonin turnover
Peters, S. L., Gray, J. A. B., & Joseph, M. H. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199106000-00005 · Cited by 39
Effects of social isolation and crowding upon adrenocortical reactivity and behavior in the rat.
Viveros, M., Hernández, R., Martínez, I. T. M., & González, P. (1988) · PubMed · Cited by 39
Individual Housing Modulates Daily Rhythms of Hypothalamic Catecholaminergic System and Circulating Hormones in Adult Male Rats
Gambardella, P., Greco, A. M., Sticchi, R., Bellotti, R., & Renzo, G. D. (1994) · Chronobiology International · doi:10.3109/07420529409067790 · Cited by 38
Behavioural Inhibition and the Age at Social Isolation in Rats
Dalrymple‐Alford, J. C., & Benton, D. (1984) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748408402192 · Cited by 38
Studies with chronically isolated rats: Tissue levels and urinary excretion of catecholamines and plasma levels of corticosterone
Moore, K. E. (1968) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y68-080 · Cited by 28
The Ontogeny of Glucocorticoid Negative Feedback: Influence of Maternal Deprivation
van Oers, H. J. J. (1998) · Endocrinology · doi:10.1210/en.139.6.2838 · Cited by 28
Acquisition and extinction of an operant response in differentially reared rats
Gluck, J. P., & Pearce, H. E. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100207 · Cited by 18
Comparison of central corticosteroid receptor expression in male Lewis and Fischer rats
Jongen‐Rêlo, A. L., Pothuizen, H. H. J., Feldon, J., & Pryce, C. R. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03293-6 · Cited by 15
Rat Latent Inhibition and Prepulse Inhibition are Sensitive to Different Manipulations of the Social Environment: A Comprehensive Study of the Environmental Approach to Neurodevelopmental Models of Schizophrenia
Feldon, J., Lehmann, J., Pryce, C. R., & Weiss, I. C. (2000) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-4860-4_13 · Cited by 12

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Authors: Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I., & Feldon, J.
Affiliations: ETH Zurich (CH)
Corresponding author: Feldon, Joram
ORCID: Pryce, Christopher R
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2004-07
Volume: 152
Issue: 2
Pages: 279-295
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2003.10.015
OpenAlex: W2076236287
Cited by: 512
References: 76
Citations by year: 2026: 7 · 2025: 20 · 2024: 26 · 2023: 18 · 2022: 29 · 2021: 33 · 2020: 46 · 2019: 25 · 2018: 19 · 2017: 30 · 2016: 22 · 2015: 25 · 2014: 25 · 2013: 24 · 2012: 26
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Branco Weiss Fellowship – Society in Science
Eidgenössische Technische Hochschule Zürich
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: social isolation, post-weaning social isolation, stress reactivity, hypothalamic-pituitary-adrenal axis, ACTH, corticosterone, mineralocorticoid receptor, glucocorticoid receptor, anxiety, fear conditioning, startle response, sex differences, neuroendocrine response, rats
MeSH terms: Adrenocorticotropic Hormone, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Brain, Conditioning, Psychological, Corticosterone, Fear, Female, Glucocorticoids, Immunohistochemistry, Kidney, Male, Motor Activity, Neurosecretory Systems, Radioimmunoassay, Random Allocation, Reflex, Acoustic, Sex Factors, Social Isolation, Stress, Physiological, Weaning, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Mineralocorticoid, Maze Learning, Rats

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Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat

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