Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845

Diagnostic and Statistical Manual of Mental Disorders.

Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120

Depression: a new animal model sensitive to antidepressant treatments

PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

The tail suspension test: A new method for screening antidepressants in mice

Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,320

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666

The Tail Suspension Test

Can, A., Dao, D. T., Terrillion, C. E., Piantadosi, S. C., Bhat, S., & Gould, T. D. (2011) · Journal of Visualized Experiments · doi:10.3791/3769 · Cited by 691

The Mouse Forced Swim Test

Can, A., Dao, D. T., Arad, M., Terrillion, C. E., Piantadosi, S. C., & Gould, T. D. (2011) · Journal of Visualized Experiments · doi:10.3791/3638 · Cited by 628

Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota

Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 563

Animal models of anxiety disorders and stress

Campos, A. C., Fogaça, M. V., de Aguiar, D. C., & Guimarães, F. S. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1139 · Cited by 510

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

Koolhaas, J. M., de Boer, S. F., Buwalda, B., & van Reenen, K. (2007) · Brain Behavior and Evolution · doi:10.1159/000105485 · Cited by 440

Chronic stress: Implications for neuronal morphology, function and neurogenesis

Joëls, M., Karst, H., Krugers, H. J., & Lucassen, P. J. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.04.001 · Cited by 381

Microbiota alteration is associated with the development of stress-induced despair behavior

Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., Wu, M., Overall, C. C., Kipnis, J., & Gaultier, A. (2017) · Scientific Reports · doi:10.1038/srep43859 · Cited by 369

Sex differences in anxiety and emotional behavior

Donner, N. C., & Lowry, C. A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1271-7 · Cited by 379

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

Guilloux, J., Seney, M. L., Edgar, N. M., & Sibille, E. L. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.01.019 · Cited by 362

Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress

Kaster, M. P., Machado, N. J., Silva, H. B., Nunes, A., Ardais, A. P., Santana, M., Baqi, Y., Müller, C. E., Rodrigues, A. L. S., Porciúncula, L. O., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423088112 · Cited by 312

Unpredictable chronic stress model in zebrafish (Danio rerio): Behavioral and physiological responses

Piato, Â., Capiotti, K. M., Tamborski, A. R., Oses, J. P., Barcellos, L. J. G., Bogo, M. R., Lara, D. R., Vianna, M. R. M. R., & Bonan, C. D. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.018 · Cited by 313

Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice

Isingrini, E., Camus, V., Le Guisquet, A.-M., Pingaud, M., Devers, S., & Belzung, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010404 · Cited by 277

Amygdala-Ventral Pallidum Pathway Decreases Dopamine Activity After Chronic Mild Stress in Rats

Chang, C.-H., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.020 · Cited by 239

Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability

Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Page, C. E., & Coutellier, L. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.024 · Cited by 213

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224

Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition

Suri, D., Veenit, V., Sarkar, A., Thiagarajan, D., Kumar, A., Nestler, E. J., Galande, S., & Vaidya, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.023 · Cited by 208

Behavioral and Brain Functions at 15

Crusio, W. E. (2020) · Behavioral and Brain Functions · doi:10.1186/s12993-020-00170-w · Cited by 201

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 203

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia

Couch, Y., Anthony, D. C., Dolgov, O., Revischin, A., Festoff, B., Santos, A. I., Steinbusch, H. W., & Strekalova, T. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.017 · Cited by 187

Neuroimmunological effects of physical exercise in depression

Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 201

Peripheral and central mechanisms of stress resilience

Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170

Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

Baptista, P., & Andrade, J. P. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00044 · Cited by 170

Functional implications of decreases in neurogenesis following chronic mild stress in mice

Mineur, Y. S., Belzung, C., & Crusio, W. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.045 · Cited by 166

Gender-Specific Impact of Brain-Derived Neurotrophic Factor Signaling on Stress-Induced Depression-Like Behavior

Autry, A. E., Adachi, M., Cheng, P., & Monteggia, L. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.007 · Cited by 154

Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in Mice

Logan, R. W., Edgar, N. M., Gillman, A. G., Hoffman, D., Zhu, X., & McClung, C. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.011 · Cited by 160

Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey

Yalçın, İ., Belzung, C., & Surget, A. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.021 · Cited by 155

The lonely mouse: Verification of a separation-induced model of depression in female mice

Martin, A. L., & Brown, R. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.006 · Cited by 158

Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain

Lomazzo, E., Bîndilă, L., Remmers, F., Lerner, R., Schwitter, C., Hoheisel, U., & Lutz, B. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.198 · Cited by 143

Identifying Molecular Substrates in a Mouse Model of the Serotonin Transporter × Environment Risk Factor for Anxiety and Depression

Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi‐Allegra, S., Cabib, S., Lesch, K., & Gross, C. T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.013 · Cited by 141

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice

Mineur, Y. S., Somenzi, O., & Picciotto, M. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.006 · Cited by 137

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

Zhu, W., Cao, F.-S., Feng, J., Chen, H.-W., Wan, J.-R., Lu, Q., & Wang, J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.037 · Cited by 134

Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity

Schweizer, M., Henniger, M. S. H., & Sillaber, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004326 · Cited by 146

Prenatal Alcohol Exposure and Chronic Mild Stress Differentially Alter Depressive‐ and Anxiety‐Like Behaviors in Male and Female Offspring

Hellemans, K. G. C., Verma, P., Yoon, E., Yu, W. K., Young, A. H., & Weinberg, J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01132.x · Cited by 133

Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior

Huynh, T. N., Krigbaum, A. M., Hanna, J. J., & Conrad, C. D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.038 · Cited by 133

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders

Shepard, R., Page, C. E., & Coutellier, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.038 · Cited by 118

Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice

Zhu, S., Shi, R., Wang, J., Wang, J., & Li, X. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000243 · Cited by 128

Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring

Babri, S., Doosti, M.-H., & Salari, A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.003 · Cited by 120

Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline

Marcon, M., Herrmann, A. P., Mocelin, R., Rambo, C. L., Koakoski, G., de Abreu, M. S., Conterato, G. M. M., Kist, L. W., Bogo, M. R., Zanatta, L. C. B., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4408-5 · Cited by 124

Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal

Ibargüen-Vargas, Y., Surget, A., Touma, C., Palme, R., & Belzung, C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.07.010 · Cited by 125

Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression

Laugeray, A., Launay, J., Callebert, J., Surget, A., Belzung, C., & Barone, P. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.014 · Cited by 117

Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice

Page, C. E., Shepard, R. M., Heslin, K. A., & Coutellier, L. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-56424-9 · Cited by 111

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Malatyńska, E., Steinbusch, H. W. M., Redkozubova, O. M., Bolkunov, A., Kubatiev, A. A., Yeritsyan, N., Vignisse, J., Бачурин, С. О., & Strekalova, T. V. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.04.010 · Cited by 114

Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions

Olugbemide, A. S., Ben‐Azu, B., Bakre, A. G., Ajayi, A. M., Femi-Akinlosotu, O. M., & Umukoro, S. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.12.003 · Cited by 110

Long-lasting effects of chronic rTMS to treat chronic rodent model of depression

Feng, S., Shi, T., FanYang, Wang, W.-N., Chen, Y.-C., & Tan, Q. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.019 · Cited by 110

Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

Barnum, C. J., Pace, T. W., Hu, F., Neigh, G. N., & Tansey, M. G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-9 · Cited by 107

DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress

Cao, W., Wang, C., Chin, Y., Chen, X., Gao, Y., Yuan, S., Xue, C., Wang, Y., & Tang, Q. (2018) · Food & Function · doi:10.1039/c8fo01404c · Cited by 104

Chronic stress and endothelial dysfunction: mechanisms, experimental challenges, and the way ahead

Sher, L. D., Geddie, H., Olivier, L., Cairns, M., Truter, N., Beselaar, L., & Essop, M. F. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00244.2020 · Cited by 111

Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress

Shepard, R., & Coutellier, L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0528-0 · Cited by 97

Models of Depression: Unpredictable Chronic Mild Stress in Mice

Nollet, M. (2021) · Current Protocols · doi:10.1002/cpz1.208 · Cited by 109

Dentate gyrus neurogenesis and depression

Sahay, A., Drew, M. R., & Hen, R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63038-6 · Cited by 104

Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex

Naik, R. R., Sotnikov, S., Diepold, R. P., Iurato, S., Markt, P. O., Bultmann, A., Brehm, N., Mattheus, T., Lutz, B., Erhardt, A., et al. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0025-2 · Cited by 111

Unpredictable chronic mild stress induces anxiety and depression-like behaviors and inactivates AMP-activated protein kinase in mice

Zhu, S., Wang, J., Zhang, Y., Li, V., Kong, J., He, J., & Li, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.002 · Cited by 101

The Clinical Implications of Mouse Models of Enhanced Anxiety

Sartori, S. B., Landgraf, R., & Singewald, N. (2011) · Future Neurology · doi:10.2217/fnl.11.34 · Cited by 103

Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm

Farley, S., Apazoglou, K., Witkin, J. M., Giros, B., & Tzavara, E. T. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991076 · Cited by 96

Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice

Patterson, Z. R., Ducharme, R., Anisman, H., & Abizaid, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07310.x · Cited by 95

Understanding neurobehavioral effects of acute and chronic stress in zebrafish

Demin, K. A., Taranov, A. S., Ilyin, N. P., Lakstygal, A. M., Volgin, A. D., de Abreu, M. S., Strekalova, T. V., & Kalueff, A. V. (2020) · Stress · doi:10.1080/10253890.2020.1724948 · Cited by 103

Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice

Juczewski, K., Koussa, J. A., Kesner, A. J., Lee, J. O., & Lovinger, D. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69132-6 · Cited by 95

Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway

Li, H., Lin, S., Qin, T., Li, H., Ma, Z., & Ma, S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.10.001 · Cited by 91

Stress and its impact on farm animals

Kumar, B. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e496 · Cited by 89

Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables

Markov, D. D., & Novosadova, E. V. (2022) · Biology · doi:10.3390/biology11111621 · Cited by 101

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Frisbee, J. C., Brooks, S., Stanley, S., & d’Audiffret, A. C. (2015) · Journal of Visualized Experiments · doi:10.3791/53109 · Cited by 89

Mechanisms underlying the antidepressant response and treatment resistance

Levinstein, M. R., & Samuels, B. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00208 · Cited by 93

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect

Rollema, H., Guanowsky, V., Mineur, Y. S., Shrikhande, A., Coe, J. W., Seymour, P. A., & Picciotto, M. R. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.002 · Cited by 87

Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling

Woo, H., Hong, C. J., Jung, S., Choe, S., & Yu, S. (2018) · Molecular Brain · doi:10.1186/s13041-018-0381-8 · Cited by 92

Evaluation of saphenous venipuncture and modified tail-clip blood collection in mice.

Abatan, O. I., Welch, K. B., & Nemzek, J. A. (2008) · PubMed Central · Cited by 86

Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway

Gawali, N. B., Bulani, V. D., Gursahani, M., Deshpande, P. S., Kothavade, P. S., & Juvekar, A. R. (2017) · Brain Research · doi:10.1016/j.brainres.2017.03.004 · Cited by 92

Chronic stress dysregulates amygdalar output to the prefrontal cortex

Lowery-Gionta, E. G., Crowley, N. A., Bukalo, O., Silverstein, S., Holmes, A., & Kash, T. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.032 · Cited by 84

Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior

Wu, T.-C., Chen, H.-T., Chang, H.-Y., Yang, C., Hsiao, M., Cheng, M., & Chen, J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.011 · Cited by 87

The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species

Seney, M. L., Chang, L.-C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00104 · Cited by 78

Mice Do Not Habituate to Metabolism Cage Housing–A Three Week Study of Male BALB/c Mice

Kalliokoski, O., Jacobsen, K. R., Darusman, H. S., Henriksen, T., Weimann, A., Poulsen, H. E., Hau, J., & Abelson, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058460 · Cited by 85

Beneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety- and depression-like behaviors

Lapmanee, S., Charoenphandhu, J., & Charoenphandhu, N. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.018 · Cited by 78

Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats

Shi, M., Wang, J., & Luo, F. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.07.002 · Cited by 79

Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?

d’Audiffret, A. C., Frisbee, S. J., Stapleton, P. A., Goodwill, A. G., Isingrini, E., & Frisbee, J. C. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01440.2009 · Cited by 79

Cytisine-based nicotinic partial agonists as novel antidepressant compounds

Mineur, Y. S., Eibl, C., Young, G., Kochevar, C., Papke, R. L., Gündisch, D., & Picciotto, M. R. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149609 · Cited by 75

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Burstein, O., & Doron, R. (2018) · Journal of Visualized Experiments · doi:10.3791/58184 · Cited by 82

Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice

Gould, T. D., O’Donnell, K. C., Picchini, A. M., Dow, E. R., Chen, G., & Manji, H. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.028 · Cited by 74

Effects of chronic and acute stressors and CRF on depression-like behavior in mice

Swiergiel, A. H., Leskov, I. L., & Dunn, A. J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.018 · Cited by 77

Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity

Mahati, K., Bhagya, V. R., Christofer, T., Sneha, A., & Rao, B. S. S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.017 · Cited by 80

Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine

Cuccurazzu, B., Bortolotto, V., Valente, M. M., Ubezio, F., Koverech, A., Canonico, P. L., & Grilli, M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.121 · Cited by 76

Mutant mice with reduced NMDA-NR1 glycine affinity or lack of d-amino acid oxidase function exhibit altered anxiety-like behaviors

Labrie, V., Clapcote, S. J., & Roder, J. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.09.016 · Cited by 73

Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling

Xiao, X., Shang, X., Zhai, B., Zhang, H., & Zhang, T. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.01.004 · Cited by 78

Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice

Jung, Y., Hong, S., Ma, S., Hwang, J.-Y., Kim, J.-S., Lee, J., Seo, J., Lee, S., & Jang, C. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.058 · Cited by 75

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

White, A. G., Elias, E., Orozco, A., Robinson, S. A., & Manners, M. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105085 · Cited by 78

Melatonin ameliorates chronic mild stress induced behavioral dysfunctions in mice

Haridas, S., Kumar, M., & Manda, K. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.06.015 · Cited by 77

Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression

Xiao, Z., Cao, Z., Yang, J., Jia, Z., Du, Y., Sun, G., Lu, Y. F., & Pei, L. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114594 · Cited by 74

Encore: Behavioural animal models of stress, depression and mood disorders

Petković, A., & Chaudhury, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.931964 · Cited by 74

Chronic unpredictable mild stress alters an anxiety-related defensive response, Fos immunoreactivity and hippocampal adult neurogenesis

de Andrade, J. S., Céspedes, I. C., Abrão, R. O., Santos, T. B., Diniz, L., Britto, L. R. G., Spadari-Bratfisch, R. C., Ortolani, D., Melo-Thomas, L., da Silva, R. C. B., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.031 · Cited by 70

Social instability is an effective chronic stress paradigm for both male and female mice

Yohn, C. N., Ashamalla, S. A., Bokka, L., Gergues, M. M., Garino, A., & Samuels, B. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107780 · Cited by 71

Mice Genetically Depleted of Brain Serotonin Do Not Display a Depression-like Behavioral Phenotype

Angoa‐Pérez, M., Kane, M. J., Briggs, D. I., Herrera‐Mundo, N., Sykes, C. E., Francescutti, D. M., & Kuhn, D. M. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500096g · Cited by 68

Chronic variable stress alters hypothalamic–pituitary–adrenal axis function in the female mouse

Borrow, A. P., Heck, A. L., Miller, A. M., Sheng, J. A., Stover, S. A., Daniels, R. M., Bales, N. J., Fleury, T. K., & Handa, R. J. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112613 · Cited by 68

Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?

Takatsu-Coleman, A. L., Patti, C. L., Zanin, K. A., Zager, A., Carvalho, R. C., Borçoi, A. R., Ceccon, L. M. B., Berro, L. F., Tufik, S., Andersen, M. L., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120050 · Cited by 66

Effects of the chronic restraint stress induced depression on reward-related learning in rats.

Xu, P., Wang, K., Lu, C., Dong, L., Chen, Y., Wang, Q., Shi, Z., Yang, Y., Chen, S., & Liu, X. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.045 · Cited by 61

Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones

Karisetty, B. C., Joshi, P., Kumar, A., & Chakravarty, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.020 · Cited by 65

Sex chromosome complement regulates expression of mood-related genes

Seney, M. L., Ekong, K. I., Ding, Y., Tseng, G. C., & Sibille, E. L. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-20 · Cited by 62

Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice

Del Boca, C., Lutz, P. E., Le Merrer, J., Koebel, P., & Kieffer, B. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.022 · Cited by 59

Between and within laboratory reliability of mouse behaviour recorded in home-cage and open-field

Robinson, L., Spruijt, B. M., & Riedel, G. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.11.019 · Cited by 59

Antidepressant-like effects of 071031B, a novel serotonin and norepinephrine reuptake inhibitor

Xue, R., Jin, Z., Chen, H., Li, Y., He, X., Zhang, Y., Meng, Y., Xu, J., Zheng, J., Zhong, B., et al. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.001 · Cited by 58

Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience

Ricon, T., Toth, E., Leshem, M., Braun, K., & Richter-Levin, G. (2012) · Stress · doi:10.3109/10253890.2011.572207 · Cited by 55

Differential effect of chronic mild stress on anxiety and depressive-like behaviors in three strains of male and female laboratory mice

Medina-Saldivar, C., Cruz-Visalaya, S. R., Zevallos-Arias, A., Pardo, G. V. E., & Otalora, L. F. P. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114829 · Cited by 12

Behavioral effects of unpredictable chronic mild stress (UCMS) in a murine model of depression

Foglio, B., Rossi, G. S. D., & Panzica, G. (2013) · Institutional Research Information System University of Turin (University of Turin) · Cited by 1

Of Depressed Mice and Men: Similar Genetic Expression in the Amygdala

Yager, J. (2009) · Journal watch · doi:10.1056/jp200908100000006

Sex differences in response to unpredictable chronic mild stress model of depression in mice

Foglio, B., A., R. G., & PANZICA, G. (2013) · Institutional Research Information System University of Turin (University of Turin)

Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal

Ibargüen-Vargas, Y., Surget, A., Touma, C., Palme, R., & Belzung, C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.07.010 · Cited by 125