Cited by 400Memory and Neural MechanismsStress Responses and CortisolAnimal Behavior and Welfare Studies

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Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

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Harrison, F.E., Hosseini, A.H., McDonald, M.P.·2009·Behavioural Brain Research

DOI 10.1016/j.bbr.2008.10.015PMC PMC2663577

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Abstract

The effects of abnormally high or low stress on learning are well established. The Barnes maze and Morris water maze are two commonly used tests of spatial memory, of which the water maze is considered more stressful; however, until now this has not been demonstrated empirically. In the present study, mice matched for performance on commonly used anxiety tasks were trained on either the Barnes maze or water maze or received no cognitive testing. Water-maze training induced greater increases in plasma corticosterone than did Barnes maze training, assessed 30 min after the final session. Importantly, spatial learning was inversely correlated with corticosterone levels in the water maze but not the Barnes maze, suggesting that performance on the water maze may be more affected by test-induced stress even within wild-type subjects of the same age and gender. These findings are important when considering the appropriate cognitive tasks for any experiment in which stress responses may differ systematically across groups.

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Authors: Harrison, F. E., Hosseini, A. H., & McDonald, M. P.
Affiliations: Vanderbilt University (US)
University of Tennessee Health Science Center (US)
Corresponding author: Harrison, F.E.
ORCID: Harrison, F.E.
McDonald, M.P.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2009-03
Volume: 198
Issue: 1
Pages: 247-251
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2008.10.015
PMC: PMC2663577
OpenAlex: W1983937997
Semantic Scholar: 2358b038bb4b6c3e5baca7861948d8bee4686ece
Cited by: 399
References: 30
Citations by year: 2026: 20 · 2025: 26 · 2024: 31 · 2023: 24 · 2022: 31 · 2021: 29 · 2020: 23 · 2019: 21 · 2018: 31 · 2017: 13 · 2016: 24 · 2015: 16 · 2014: 22 · 2013: 25 · 2012: 19
FWCI: 7.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG022439, AG-022439)
National Institute of Diabetes and Digestive and Kidney Diseases (DK59637, DK 20593, U24DK059637, P30DK020593)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
Keywords: spatial memory, water maze, Barnes maze, corticosterone, anxiety, stress hormones, spatial learning, mice, cognitive assessment
MeSH terms: Analysis of Variance, Animals, Anxiety, Cognition, Corticosterone, Exploratory Behavior, Male, Memory, Mice, Inbred C57BL, Psychomotor Performance, Radioimmunoassay, Social Behavior, Space Perception, Spatial Behavior, Stress, Psychological, Swimming, Maze Learning, Mice

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Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

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