The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex
Open accessAbstract
A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.
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“Consistent with the original FDA label, rTMS for MDD most commonly targets the left hemisphere DLPFC, a key node in the functional pathophysiology thought to underlie depressive symptoms (21).”
From Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods (2025) · cites this paper as [21]
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“Furthermore, damage to the ventromedial prefrontal cortex has been associated with emotional deficits including diminished guilt (Koenigs & Grafman, 2009)”
From A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression (2017) · cites this paper as Koenigs & Grafman, 2009
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“Substantial evidence indicates that mPFC dysfunction plays a critical role in the pathology of major depressive disorder (MDD) 203.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [203]
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“One recent review of brain function in depression [71] concluded that depression is typified by hypoactivation in dorsolateral PFC (including dorsal ACC), as well as hyperactivation in ventromedial PFC (including subgenual ACC).”
From Arrested development? Reconsidering dual-systems models of brain function in adolescence and disorders (2012) · cites this paper as [71]
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“Research efforts aimed at understanding the neural circuits underlying depression have been mainly devoted to the prefrontal cortex, hippocampus, and mesolimbic structures [12, 55, 56].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [12]
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977
Damage to the prefrontal cortex increases utilitarian moral judgements
Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., & Damasio, A. (2007) · Nature · doi:10.1038/nature05631 · Cited by 1,545
Self-citationReduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression
Baxter, L. R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810030049007 · Cited by 1,320
DAMASIO, A. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90144-4 · Cited by 1,275
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · cited 1×
“…4 February 2009 Accepted 3 March 2009 Available online 17 March 2009 Keywords: Depression Ventromedial prefrontal cortex Dorsolateral prefrontal cortex a b s t r a c t A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms.”
BackgroundMayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.030 · Cited by 892
The Involvement of the Orbitofrontal Cortex in the Experience of Regret
Camille, N., Coricelli, G., Sallet, J., Pradat-Diehl, P., Duhamel, J.-R., & Sirigu, A. (2004) · Science · doi:10.1126/science.1094550 · Cited by 716
Neural circuitry underlying voluntary suppression of sadness
Lévesque, J., Eugène, F., Joanette, Y., Paquette, V., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., & Beauregard, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01817-6 · Cited by 689
Barbas, H. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00245-2 · Cited by 664
Cognitive control and brain resources in major depression: An fMRI study using the n-back task
Harvey, P.-O., Fossati, P., Pochon, J.-B., Levy, R., LeBastard, G., Lehéricy, S., Allilaire, J.-F., & Dubois, B. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.048 · Cited by 534
Functional neuroimaging studies of depression: The anatomy of melancholia
Drevets, W. C. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.341 · Cited by 500 · cited 1×
“…4 February 2009 Accepted 3 March 2009 Available online 17 March 2009 Keywords: Depression Ventromedial prefrontal cortex Dorsolateral prefrontal cortex a b s t r a c t A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms.”
BackgroundBeer, J. S., John, O. P., Scabini, D., & Knight, R. T. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.6.871 · Cited by 455
Regulation of emotional responses elicited by threat-related stimuli
Eippert, F., Veit, R., Weiskopf, N., Erb, M., Birbaumer, N., & Anders, S. (2007) · Human Brain Mapping · doi:10.1002/hbm.20291 · Cited by 419
Orbitofrontal cortex function and structure in depression
DREVETS, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.029 · Cited by 417 · cited 1×
“…4 February 2009 Accepted 3 March 2009 Available online 17 March 2009 Keywords: Depression Ventromedial prefrontal cortex Dorsolateral prefrontal cortex a b s t r a c t A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms.”
BackgroundBarrash, J., Tranel, D., & Anderson, S. W. (2000) · Developmental Neuropsychology · doi:10.1207/s1532694205barrash · Cited by 412
Frontal and parietal metabolic disturbances in unipolar depression
Biver, F., Goldman, S., Delvenne, V., Luxen, A., De Maertelaer, V., Hubain, P., Mendlewicz, J., & Lotstra, F. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91213-0 · Cited by 313
Functional heterogeneity of the prefrontal cortex in the monkey: a review
Rosenkilde, C. E. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90404-7 · Cited by 306
Loo, C. K. A., & Mitchell, P. B. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.08.001 · Cited by 300
Wagner, G., Sinsel, E., Sobanski, T., Köhler, S., Marinou, V., Mentzel, H.-J., Sauer, H., & Schlösser, R. G. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.025 · Cited by 278
Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression
Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., & Grafman, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2324-08.2008 · Cited by 243
Self-citationHypofrontality and negative symptoms in major depressive disorder.
GALYNKER, I. I., Cai, J., Ongseng, F., Finestone, H., Dutta, E., & Serseni, D. (1998) · PubMed · Cited by 238
Brain metabolic changes associated with symptom factor improvement in major depressive disorder
Brody, A. L., Saxena, S., Mandelkern, M. A., Fairbanks, L. A., Ho, M. L., & Baxter, L. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01117-9 · Cited by 212
Zald, D. H., Mattson, D. L., & Pardo, J. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042457199 · Cited by 186
A Further Review of the Results of Stereotactic Subcaudate Tractotomy
Göktepe, E. O., Young, L. B., & Bridges, P. K. (1975) · The British Journal of Psychiatry · doi:10.1192/bjp.126.3.270 · Cited by 163
Psychosurgery: Stereotactic Subcaudate Tractotomy
Bridges, P. K., Bartlett, J. R., Hale, A. S., Poynton, A., Malizia, A. L., & Hodgkiss, A. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.5.599 · Cited by 132
Neurostimulation therapies in depression: a review of new modalities
Marangell, L. B., Martínez, M., Jurdi, R. A., & Zboyan, H. A. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01033.x · Cited by 107
Long-Term Outcome of Neurosurgery for the Treatment of Resistant Depression
Sachdev, P. S., & Sachdev, J. (2005) · Journal of Neuropsychiatry · doi:10.1176/jnp.17.4.478 · Cited by 46
The Lesion in Stereotactic Subcaudate Tractotomy
Newcombe, R. L. G. (1975) · The British Journal of Psychiatry · doi:10.1192/bjp.126.5.478 · Cited by 40
Orbital Versus Dorsolateral Prefrontal Cortex
Zald, D. H. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.012 · Cited by 33
Ventromedial frontal lobe trauma
Ellenbogen, J. M., Hurford, M. O., Liebeskind, D. S., Neimark, G. B., & Weiss, D. (2005) · Neurology · doi:10.1212/wnl.64.4.757 · Cited by 20
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Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
Lefaucheur, J., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F. M., Cotelli, M., Ridder, D. D., Ferrucci, R., Langguth, B., et al. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.10.087 · Cited by 1,968
“The rationale for the use of tDCS in the treatment of depressive disorders is based on the knowledge of functional and structural abnormalities in the left and right dorsolateral and ventromedial prefrontal cortex, amygdala and hippocampus in depressed patients (Campbell et al., 2004; Hamilton et al., 2008; Koenigs an…”
BackgroundA technical guide to tDCS, and related non-invasive brain stimulation tools
Woods, A. J., Antal, A., Bikson, M., Boggio, P. S., Brunoni, A. R., Celnik, P. A., Cohen, L. G., Fregni, F., Herrmann, C. S., Kappenman, E. S., et al. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.11.012 · Cited by 1,548
“Thus, in most cases, electrodes are positioned over the area associated with the pathology under study – for instance, in depression electrodes are placed over the dorsolateral prefrontal cortex, an area in which activity is pathologically altered (Koenigs and Grafman, 2009).”
BackgroundFox, M. D., Buckner, R. L., White, M. P., Greicius, M. D., & Pascual-Leone, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.028 · Cited by 1,270
Resting-state functional connectivity in major depressive disorder: A review
Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial
Cole, E. J., Phillips, A. L., Bentzley, B. S., Stimpson, K. H., Nejad, R., Barmak, F., Veerapal, C., Khan, N., Cherian, K., Felber, E., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.20101429 · Cited by 795
Metadata
- Authors
- Koenigs, M., & Grafman, J.
- Affiliations
- University of Wisconsin–Madison (US)
- National Institutes of Health (US)
- Corresponding author
- Koenigs, Michael
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 201
- Issue
- 2
- Pages
- 239-243
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2680780
- OpenAlex
- W2156809536
- Cited by
- 956
- References
- 39
- Citations by year
- 2026: 43 · 2025: 54 · 2024: 60 · 2023: 60 · 2022: 83 · 2021: 88 · 2020: 64 · 2019: 80 · 2018: 77 · 2017: 52 · 2016: 70 · 2015: 55 · 2014: 38 · 2013: 41 · 2012: 38
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (Z01NS002792)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, prefrontal cortex, functional neuroanatomy, brain lesions, transcranial magnetic stimulation, functional imaging
- MeSH terms
- Brain Mapping, Depression, Depressive Disorder, Humans, Prefrontal Cortex, Transcranial Magnetic Stimulation
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