Cited by 716Neural and Behavioral Psychology StudiesDecision-Making and Behavioral EconomicsNeurotransmitter Receptor Influence on Behavior

The Involvement of the Orbitofrontal Cortex in the Experience of Regret

Camille, Nathalie, Coricelli, Giorgio, Sallet, Jerome, Pradat-Diehl, Pascale, Duhamel, Jean-René, Sirigu, Angela·2004·Science

Abstract

Facing the consequence of a decision we made can trigger emotions like satisfaction, relief, or regret, which reflect our assessment of what was gained as compared to what would have been gained by making a different decision. These emotions are mediated by a cognitive process known as counterfactual thinking. By manipulating a simple gambling task, we characterized a subject's choices in terms of their anticipated and actual emotional impact. Normal subjects reported emotional responses consistent with counterfactual thinking; they chose to minimize future regret and learned from their emotional experience. Patients with orbitofrontal cortical lesions, however, did not report regret or anticipate negative consequences of their choices. The orbitofrontal cortex has a fundamental role in mediating the experience of regret.

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Crossref · 10.1126/science.1094550

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Authors
Camille, N., Coricelli, G., Sallet, J., Pradat-Diehl, P., Duhamel, J.-R., & Sirigu, A.
Affiliations
  • University of Siena (IT)
  • Institut des Sciences Cognitives, CNRS, 67, Boulevard Pinel 69675 Bron, France.
Corresponding author
  • Camille, Nathalie
  • Coricelli, Giorgio
Venue
Science
Published
2004-05-21
Volume
304
Issue
5674
Pages
1167-1170
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2037444091
Cited by
716
References
16
Citations by year
2026: 16 · 2025: 21 · 2024: 20 · 2023: 22 · 2022: 20 · 2021: 36 · 2020: 68 · 2019: 37 · 2018: 20 · 2017: 27 · 2016: 23 · 2015: 42 · 2014: 41 · 2013: 35 · 2012: 40
FWCI
14.24
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
orbitofrontal cortex, regret, counterfactual reasoning, decision-making, emotional experience, gambling task, anticipated emotions
MeSH terms
Adult, Brain Diseases, Choice Behavior, Decision Making, Emotions, Female, Frontal Lobe, Galvanic Skin Response, Gambling, Humans, Male, Middle Aged, Models, Psychological, Thinking, Feedback, Psychological

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