Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices
Abstract
Distinct domains of the prefrontal cortex in primates have a set of connections suggesting that they have different roles in cognition, memory, and emotion. Caudal lateral prefrontal areas (areas 8 and 46) receive projections from cortices representing early stages in visual or auditory processing, and from intraparietal and posterior cingulate areas associated with oculomotor guidance and attentional processes. Cortical input to areas 46 and 8 is complemented by projections from the thalamic multiform and parvicellular sectors of the mediodorsal nucleus associated with oculomotor functions and working memory. In contrast, caudal orbitofrontal areas receive diverse input from cortices representing late stages of processing within every unimodal sensory cortical system. In addition, orbitofrontal and caudal medial (limbic) prefrontal cortices receive robust projections from the amygdala, associated with emotional memory, and from medial temporal and thalamic structures associated with long-term memory. Prefrontal cortices are linked with motor control structures related to their specific roles in central executive functions. Caudal lateral prefrontal areas project to brainstem oculomotor structures, and are connected with premotor cortices effecting head, limb and body movements. In contrast, medial prefrontal and orbitofrontal limbic cortices project to hypothalamic visceromotor centers for the expression of emotions. Lateral, orbitofrontal, and medial prefrontal cortices are…
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The vmPFC receives connections from all exteroceptive and interoceptive modalities and has been viewed as a polymodal convergence zone supporting the integration of external and internal stimuli with judgements about their affective relevance to the self.
“As this region receives connections from all exteroceptive (Barbas, 2000) and interoceptive modalities (Carmichael and Price, 1996), it has been viewed as a polymodal convergence zone (Rolls, 2000), supporting the integration of external and internal stimuli with judgements about their affective relevance to the self (Ochsner and Gross, 2005).”
From Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference (2007) · cites this paper as Barbas, 2000
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- Authors
- Barbas, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Barbas, Helen
- ORCID
- Barbas, Helen
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 52
- Issue
- 5
- Pages
- 319-330
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2087913227
- Cited by
- 664
- References
- 12
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 31 · 2023: 7 · 2022: 15 · 2021: 21 · 2020: 18 · 2019: 22 · 2018: 22 · 2017: 15 · 2016: 37 · 2015: 37 · 2014: 35 · 2013: 34 · 2012: 35
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prefrontal cortex, primate brain, orbitofrontal cortex, medial prefrontal cortex, mediodorsal thalamus, amygdala, emotional memory, working memory, oculomotor control, attention, central executive function, emotional expression
- MeSH terms
- Animals, Cognition, Emotions, Humans, Hypothalamus, Limbic System, Macaca mulatta, Memory, Nervous System Diseases, Neural Pathways, Neurons, Afferent, Thalamus, Prefrontal Cortex
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