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Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in mice
Open accessAbstract
There is a current controversy regarding whether non-human animals have a capacity for episodic memory, defined by the ability to remember what happened and where and when it occurred. It is also unclear which brain structures support the "what," "where," and "when" aspects of episodic memory. Here we addressed these issues by testing episodic memory in mice, using an object recognition task that has previously been employed to assess the "what," "where," and "when" components of recognition memory. Whereas intact mice remembered which objects they had explored, as well as when and where they were experienced, mice with damage to the hippocampus were impaired on all three components of the task. In contrast, animals with medial prefrontal cortical lesions were selectively impaired on the "where" component of the task, but had intact memory for "what" and "when." These results are consistent with the hypothesis that the hippocampus integrates the "what," "where," and "when" features of unique experiences, whereas the prefrontal cortex makes a more selective contribution to retrieving source information about where events occurred.
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“These observations are supported by research using established episodic-like memory paradigms, showing that rodents with hippocampal lesions fail in both what–where–when tasks [70,72] as well as incidental encoding tasks [82].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [72]
In the citing paper
“Mice with lesion of the mPFC showed the impaired where, but not what or when, component assessed in the ELM2–1 test (DeVito and Eichenbaum, 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito and Eichenbaum, 2010
In the citing paper
“Mice with hippocampal lesions were impaired in the what, where and when components in the ELM2–1 paradigm”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito and Eichenbaum, 2010
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Metadata
- Authors
- DeVito, L. M., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Eichenbaum, Howard
- ORCID
- Eichenbaum, Howard
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 215
- Issue
- 2
- Pages
- 318-325
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2891645
- OpenAlex
- W2102411019
- Cited by
- 164
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 30 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 16 · 2014: 5 · 2013: 14 · 2012: 12
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH060450, R01MH059357)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- episodic-like memory, hippocampus, medial prefrontal cortex, object recognition memory, source memory, hippocampal lesions, prefrontal cortex lesions, mice, recognition memory
- MeSH terms
- Animals, Hippocampus, Ibotenic Acid, Male, Mice, Inbred C57BL, Microinjections, Mental Recall, N-Methylaspartate, Prefrontal Cortex, Mice
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