On the delay-dependent involvement of the hippocampus in object recognition memory

HAMMOND, R

doi:10.1016/j.nlm.2004.03.005

Cited by 476Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

On the delay-dependent involvement of the hippocampus in object recognition memory

HAMMOND, R·2004·Neurobiology of Learning and Memory

DOI 10.1016/j.nlm.2004.03.005

Open this paper in CoChat — free account

Abstract

The role of the hippocampus in object recognition memory processes is unclear in the current literature. Conflicting results have been found in lesion studies of both primates and rodents. Procedural differences between studies, such as retention interval, may explain these discrepancies. In the present study, acute lidocaine administration was used to temporarily inactivate the hippocampus prior to training in the spontaneous object recognition task. Male C57BL/6J mice were administered bilateral lidocaine (4%, 0.5 microl/side) or aCSF (0.5 microl/side) directly into the CA1 region of the dorsal hippocampus 5 min prior to sample object training, and object recognition memory was tested after a short ( 5 min) or long (24 h) retention interval. There was no effect of intra-hippocampal lidocaine on the time needed for mice to accumulate sample object exploration, suggesting that inactivation of the hippocampus did not affect sample session activity or the motivation to explore objects. Lidocaine-treated mice exhibited impaired object recognition memory, measured as reduced novel object preference, after a 24 h but not a 5 min retention interval. These data support a delay-dependent role for the hippocampus in object recognition memory, an effect consistent with the results of hippocampal lesion studies conducted in rats. However, these data are also consistent with the view that the hippocampus is involved in object recognition memory regardless of retention interval, and that object recognition processes of parahippocampal structures (e.g., perirhinal cortex) are sufficient to support object recognition memory over short retention intervals.

Integrity signals

Registry

Crossref · 10.1016/j.nlm.2004.03.005

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pre-sample intra-hippocampus infusions of lidocaine or muscimol disrupted NOP memory tested 24 hours later in mice.
“Alternatively, pre-sample intra-hippocampus infusions of lidocaine (Hammond et al., 2004) or muscimol (Cohen et al., 2013) was reported to disrupt NOP memory tested 24 hours later in mice.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Hammond et al., 2004
For the 24 h intertrial interval from familiarization to test phase used in this study, hippocampal activity is required.
“However, some human and primate studies have shown that hippocampal lesions result in impaired object recognition (41, 42) and that, for the 24 h intertrial interval from familiarization to test phase used in our study, hippocampal activity is required (43).”
From Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein (2010) · cites this paper as [43]

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413 · see citing works
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,867 · see citing works
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,555 · see citing works
Structure and function of declarative and nondeclarative memory systems
Squire, L. R., & Zola, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13515 · Cited by 1,327 · see citing works
Spatial learning with a minislab in the dorsal hippocampus.
Moser, M., Moser, E. I., Forrest, E., Andersen, P. N., & Morris, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9697 · Cited by 902 · see citing works
Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5
Morris, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03040.1989 · Cited by 765 · see citing works
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765 · see citing works
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740 · see citing works
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z. (2000) · Nature Neuroscience · doi:10.1038/72945 · Cited by 737 · see citing works
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714 · see citing works
Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix
Ennaceur, A., Neave, N., & Aggleton, J. P. (1997) · Experimental Brain Research · doi:10.1007/pl00005603 · Cited by 670 · see citing works
Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning
Morris, R., Schenk, F., Tweedie, F., & Jarrard, L. E. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00014.x · Cited by 661 · see citing works
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
Davis, S., Butcher, S., & Morris, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00021.1992 · Cited by 539 · see citing works
A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory
Blum, S., Moore, A. N., Adams, F., & Dash, P. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03535.1999 · Cited by 522 · see citing works
Reversible neural inactivation reveals hippocampal participation in several memory processes
Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V. L., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. (1999) · Nature Neuroscience · doi:10.1038/13202 · Cited by 478 · see citing works
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
Zola, S. M., Squire, L. R., Teng, E., Stefanacci, L., Buffalo, E. A., & Clark, R. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00451.2000 · Cited by 477 · see citing works
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction
Corcoran, K. A., & Maren, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01720.2001 · Cited by 455 · see citing works
Different Contributions of the Hippocampus and Perirhinal Cortex to Recognition Memory
Wan, H., Aggleton, J. P., & Brown, M. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01142.1999 · Cited by 449 · see citing works
Object Recognition and Location Memory in Monkeys with Excitotoxic Lesions of the Amygdala and Hippocampus
Murray, E. A., & Mishkin, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06568.1998 · Cited by 434 · see citing works
Activation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in Hippocampal Circuitry Is Required for Consolidation and Reconsolidation of Recognition Memory
Kelly, A. M., Laroche, S., & Davis, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05354.2003 · Cited by 361 · see citing works
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
The hippocampus and mechanisms of declarative memory
Eichenbaum, H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00044-3 · Cited by 353 · see citing works
A Necessity for MAP Kinase Activation in Mammalian Spatial Learning
Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.5.478 · Cited by 341 · see citing works
Impaired recognition memory in patients with lesions limited to the hippocampal formation.
Reed, J. M., & Squire, L. R. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.667 · Cited by 295 · see citing works
Effects of Stress and Hippocampal NMDA Receptor Antagonism on Recognition Memory in RatsPreprint
Baker, K. B., & Kim, J. J. (2002) · Learning & Memory · doi:10.1101/lm.46102 · Cited by 292 · see citing works
Time-Dependent Relationship between the Dorsal Hippocampus and the Prefrontal Cortex in Spatial Memory
Lee, I., & Kesner, R. P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01517.2003 · Cited by 287 · see citing works
Small Conductance Ca2+-Activated K+Channels Modulate Synaptic Plasticity and Memory Encoding
Stackman, R. W., Hammond, R., Linardatos, E., Gerlach, A. C., Maylie, J., Adelman, J. P., & Tzounopoulos, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10163.2002 · Cited by 275 · see citing works
Self-citation
Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat
Bussey, T. J., Duck, J., Muir, J. L., & Aggleton, J. P. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00155-8 · Cited by 252 · see citing works
Performance of different mouse strains in an object recognition task
Şık, A., van Nieuwehuyzen, P., Prickaerts, J., & Blokland, A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00117-7 · Cited by 215 · see citing works
Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks
Sutherland, R. J., Weisend, M. P., Mumby, D. G., Astur, R. S., Hanlon, F. M., Koerner, A., Thomas, M. J., Wu, Y., Moses, S. N., Cole, C., et al. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 190 · see citing works
Extensive Cytotoxic Lesions Involving Both the Rhinal Cortices and Area TE Impair Recognition But Spare Spatial Alternation in the Rat
Aggleton, J. P., Keen, S., Warburton, E. C., & Bussey, T. J. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00007-5 · Cited by 168 · see citing works
Retrograde and anterograde object recognition in rats with hippocampal lesions
Gaskin, S., Tremblay, A., & Mumby, D. G. (2003) · Hippocampus · doi:10.1002/hipo.10154 · Cited by 160 · see citing works
The use of local anaesthetic microinjections to identify central pathways: a quantitative evaluation of the time course and extent of the neuronal block
Sandk�hler, J., Maisch, B., & Zimmermann, M. (1987) · Experimental Brain Research · doi:10.1007/bf00255242 · Cited by 153 · see citing works
Scopolamine-induced deficits in a two-trial object recognition task in mice
Dodart, J., Mathis, C., & Ungerer, A. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00023 · Cited by 149 · see citing works
Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations
Mumby, D. G. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00097-2 · Cited by 145 · see citing works
Hippocampal lesions impair contextual fear conditioning in two strains of mice.
Chen, C., Kim, J. J., Thompson, R. F., & Tonegawa, S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.5.1177 · Cited by 142 · see citing works
Equivalent impairment of spatial and nonspatial memory following damage to the human hippocampus
Cave, C. B., & Squire, L. R. (1991) · Hippocampus · doi:10.1002/hipo.450010323 · Cited by 139 · see citing works
Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice
Cho, Y. H., Friedman, E. L., & Silva, A. J. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00054-0 · Cited by 134 · see citing works
The Parahippocampal Region and Object Identification
Murray, E. A., Bussey, T. J., Hampton, R. R., & Saksida, L. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06725.x · Cited by 127 · see citing works
The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks.
Liu, P., & Bilkey, D. K. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.1.94 · Cited by 117 · see citing works
The hippocampus and long-term object memory in the rat
Vnek, N., & Rothblat, L. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02780.1996 · Cited by 113 · see citing works
Mapping visual recognition memory through expression of the immediate early gene c-fos
Zhu, X.-O., McCabe, B. J., Aggleton, J. P., & Brown, M. W. (1996) · Neuroreport · doi:10.1097/00001756-199607290-00037 · Cited by 112 · see citing works
THE FIMBRIA-FORNIX/CINGULAR BUNDLE PATHWAYS: A REVIEW OF NEUROCHEMICAL AND BEHAVIOURAL APPROACHES USING LESIONS AND TRANSPLANTATION TECHNIQUES
Cassel, J., Duconseille, E., Jeltsch‐David, H., & Will, B. E. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00009-9 · Cited by 110 · see citing works
Disconnecting hippocampal projections to the anterior thalamus produces deficits on tests of spatial memory in rats
Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L., & Aggleton, J. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00039.x · Cited by 106 · see citing works
Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys
Zola, S. M., & Squire, L. R. (2001) · Hippocampus · doi:10.1002/hipo.1027 · Cited by 90 · see citing works
Recognition Memory for Complex Visual Discriminations Is Influenced by Stimulus Interference in Rodents With Perirhinal Cortex DamagePreprint
Gilbert, P. E., & Kesner, R. P. (2003) · Learning & Memory · doi:10.1101/lm.64503 · Cited by 62 · see citing works
NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice
Bardgett, M. E., Boeckman, R., Krochmal, D. J., Fernando, H., Ahrens, R. C., & Csernansky, J. G. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00023-6 · Cited by 56 · see citing works
Long lasting functional alterations in the rat dentate gyrus following entorhinal cortex lesion: A current source density analysis
Clusmann, H., Nitsch, R., & Heinemann, U. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90403-0 · Cited by 34 · see citing works
Differential neuronal responsiveness in primate perirhinal cortex and hippocampal formation during performance of a conditional visual discrimination task
Xiang, J. ‐., & Brown, M. W. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00790.x · Cited by 34 · see citing works
Perirhinal cortex ablation in rats selectively impairs object identification in a simultaneous visual comparison task.
Gaffan, E. A., Eacott, M. J., & Simpson, E. L. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.1.18 · Cited by 33 · see citing works
Untitled work
(1998) · doi:10.1002/(sici)1098-1063(1998)8:6
Untitled work
(1999) · doi:10.1002/(sici)1098-1063(1999)9:5

Flagged first, then by citations

Sorted by citations

The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684 · see citing works
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Colombo, L., Manzoni, C., Borsello, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911829107 · Cited by 466 · see citing works
Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice
Yang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6107-11.2012 · Cited by 369 · see citing works
Towards a functional organization of episodic memory in the medial temporal lobe
Eichenbaum, H., Sauvage, M., Fortin, N., Komorowski, R., & Lipton, P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.006 · Cited by 354 · see citing works
Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.068 · Cited by 363 · see citing works
The rodent hippocampus is essential for nonspatial object memory
Cohen, S. J., Munchow, A. H., Rios, L. M., Zhang, G., Ásgeirsdóttir, H. N., & Stackman, R. W. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.002 · Cited by 325 · see citing works
On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory
Rossato, J. I., Bevilaqua, L. R. M., Myskiw, J. C., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Learning & Memory · doi:10.1101/lm.422607 · Cited by 282 · see citing works
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition
Kvajo, M., McKellar, H., Arguello, P. A., Drew, L. J., Moore, H., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802615105 · Cited by 268 · see citing works
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
Haettig, J., Stefanko, D. P., Multani, M. L., Figueroa, D. X., McQuown, S. C., & Wood, M. A. (2011) · Learning & Memory · doi:10.1101/lm.1986911 · Cited by 211 · see citing works
Secreted protein lipocalin‐2 promotes microglial M1 polarization
Jang, E., Lee, S., Kim, J., Kim, J., Seo, J., Lee, W., Mori, K., Nakao, K., & Suk, K. (2013) · The FASEB Journal · doi:10.1096/fj.12-222257 · Cited by 198 · see citing works
Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer’s disease
Balducci, C., Frasca, A., Zotti, M., La Vitola, P., Mhillaj, E., Grigoli, E., Iacobellis, M., Grandi, F., Messa, M., Colombo, L., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.10.012 · Cited by 164 · see citing works
Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in mice
DeVito, L. M., & Eichenbaum, H. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.014 · Cited by 164 · see citing works
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex
Watson, D. J., Loiseau, F., Ingallinesi, M., Millan, M. J., Marsden, C. A., & Fone, K. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.254 · Cited by 151 · see citing works
PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model
Katsouri, L., Lim, Y. M., Blondrath, K., Eleftheriadou, I., Lombardero, L., Birch, A. M., Mirzaei, N., Irvine, E. E., Mazarakis, N. D., & Sastre, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606171113 · Cited by 146 · see citing works
Nobiletin, a Citrus Flavonoid, Improves Cognitive Impairment and Reduces Soluble Aβ Levels in a Triple Transgenic Mouse Model of Alzheimer’s Disease (3XTg-AD)
Nakajima, A., Aoyama, Y., Shin, E.-J., Nam, Y., Kim, H.-C., Nagai, T., Yokosuka, A., Mimaki, Y., Yokoi, T., Ohizumi, Y., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.028 · Cited by 138 · see citing works
Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type
Bassani, T. B., Turnes, J. M., Moura, E. L. R., Bonato, J. M., Cóppola-Segovia, V., Zanata, S. M., Oliveira, R. M. M. W., & Vital, M. A. B. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.014 · Cited by 134 · see citing works
Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-Accelerated Mouse
Nakajima, A., Aoyama, Y., Nguyen, T.-T. L., Shin, E.-J., Kim, H.-C., Yamada, S., Nakai, T., Nagai, T., Yokosuka, A., Mimaki, Y., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.025 · Cited by 115 · see citing works
Preventing adolescent stress-induced cognitive and microbiome changes by diet
Provensi, G., Schmidt, S. D., Boehme, M., Bastiaanssen, T. F. S., Rani, B., Costa, A., Busca, K., Fouhy, F., Strain, C., Stanton, C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820832116 · Cited by 110 · see citing works
Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.002 · Cited by 88 · see citing works
Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer's Disease
Davis, K. E., Easton, A., Eacott, M. J., & Gigg, J. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-121543 · Cited by 82 · see citing works
Study of CA1 place cell activity and exploratory behavior following spatial and nonspatial changes in the environment
Lenck-Santini, P.-P., Rivard, B., Muller, R. U., & Poucet, B. (2005) · Hippocampus · doi:10.1002/hipo.20060 · Cited by 81 · see citing works
Brain networks activated to form object recognition memory
Tanimizu, T., Kono, K., & Kida, S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.017 · Cited by 81 · see citing works
Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice
Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76 · see citing works
Paternal experience suppresses adult neurogenesis without altering hippocampal function in Peromyscus californicus
Glasper, E. R., Kozorovitskiy, Y., Pavlic, A., & Gould, E. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22628 · Cited by 66 · see citing works
Temporary inactivation reveals that the CA1 region of the mouse dorsal hippocampus plays an equivalent role in the retrieval of long-term object memory and spatial memory
Stackman, R. W., Cohen, S. J., Lora, J. C., & Rios, L. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.016 · Cited by 66 · see citing works
Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat
Jenkins, T. A., Harte, M. K., Stenson, G., & Reynolds, G. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.014 · Cited by 61 · see citing works
Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57BL/6J mice
Zhang, G., Cinalli, D., Cohen, S. J., Knapp, K. D., Rios, L. M., Martínez-Hernández, J., Luján, R., & Stackman, R. W. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.033 · Cited by 41 · see citing works
Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay
Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J. (2017) · Learning & Memory · doi:10.1101/lm.044784.116 · Cited by 35 · see citing works
Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo
Hopkins, S. C., Campbell, U. C., Heffernan, M. L. R., Spear, K. L., Jeggo, R. D., Spanswick, D. C., Varney, M. A., & Large, T. H. (2013) · Pharmacology Research & Perspectives · doi:10.1002/prp2.7 · Cited by 34 · see citing works
Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved
Ebrahimnejad, M., Azizi, P., Alipour, V., Zarrindast, M.-R., & Vaseghi, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03552-w · Cited by 21 · see citing works
Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition
Sugita, M., Yamada, K., Iguchi, N., & Ichitani, Y. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.001 · Cited by 14 · see citing works

The parahippocampal region in temporal lobe epilepsy
Scharfman, H. E. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198509172.003.0016 · Cited by 10 · see citing works
Perirhinal cortex and the recognition of relative familiarity
Ameen‐Ali, K. E., Sivakumaran, M. H., Eacott, M. J., O’Connor, A. R., Ainge, J. A., & Easton, A. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107439 · Cited by 8 · see citing works
Multiple routes to memory: distinct medial temporal lobe processes build item and source memories
Davachi, L., Mitchell, J. P., & Wagner, A. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337195100 · Cited by 899 · see citing works
Separate but interacting recognition memory systems for different senses: The role of the rat perirhinal cortexPreprint
Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M., & Aggleton, J. P. (2011) · Learning & Memory · doi:10.1101/lm.2132911 · Cited by 39 · see citing works
Flavor and object recognition memory impairment induced by excitotoxic lesions of the perirhinal cortex
Morillas, E., Gómez-Chacón, B., & Gallo, M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.08.002 · Cited by 24 · see citing works

Authors: HAMMOND, R.
Affiliations: Oregon Health & Science University (US)
Corresponding author: HAMMOND, R
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2004-07
Volume: 82
Issue: 1
Pages: 26-34
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/j.nlm.2004.03.005
OpenAlex: W2012482368
Cited by: 476
References: 57
Citations by year: 2026: 11 · 2025: 19 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 30 · 2020: 30 · 2019: 26 · 2018: 29 · 2017: 20 · 2016: 32 · 2015: 25 · 2014: 20 · 2013: 30 · 2012: 20
FWCI: 6.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (T32DA007262, 5T32 DA07262)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampus, object recognition memory, retention interval, lidocaine inactivation, CA1, novel object preference, perirhinal cortex, mice
MeSH terms: Anesthetics, Local, Animals, Exploratory Behavior, Form Perception, Hippocampus, Lidocaine, Male, Mice, Inbred C57BL, Microinjections, Reaction Time, Time Factors, Recognition, Psychology, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

On the delay-dependent involvement of the hippocampus in object recognition memory

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks