Recollection-like memory retrieval in rats is dependent on the hippocampus
Open accessAbstract
Recognition memory may be supported by two independent types of retrieval, conscious recollection of a specific experience and a sense of familiarity gained from previous exposure to particular stimuli. In humans, signal detection techniques have been used to distinguish recollection and familiarity, respectively, in asymmetrical and curvilinear components of their receiver operating characteristic (ROC) curves, standard curves that represent item recognition across different levels of confidence or bias. To determine whether animals also employ multiple processes in recognition memory and to explore the anatomical basis of this distinction, we adapted these techniques to examine odour recognition memory in rats. Their ROC curve had asymmetrical and curvilinear components, indicating the existence of both recollection and familiarity in rats. Furthermore, following selective damage to the hippocampus the ROC curve became entirely symmetrical and remained curvilinear, supporting the view that the hippocampus specifically mediates the capacity for recollection.
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Rats and mice show episodic-like memory, a prototype of episodic memory, defined by an integrated memory of the experience of an object or event, in a particular place and time.
“Rats and mice have been demonstrated to show episodic-like memory, a prototype of episodic memory, as defined by an integrated memory of the experience of an object or event, in a particular place and time.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Fortin et al., 2004
Animals can show a memory akin to human episodic memory, with arguments based on evolution, neuroanatomy and neurobiology.
“The past two decades studies have revealed new insight on this question with evidence that animals can show a memory akin to human episodic memory, with arguments based on evolution, neuroanatomy and neurobiology (Allen and Fortin, 2013; Fortin et al., 2004; Manns and Eichenbaum, 2006; Templer and Hampton, 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Fortin et al., 2004
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- Authors
- Fortin, N. J., Wright, S. P., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Eichenbaum, Howard
- Venue
- Nature
- Published
- 2004-09
- Volume
- 431
- Issue
- 7005
- Pages
- 188-191
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4053162
- OpenAlex
- W2068395896
- Cited by
- 460
- References
- 31
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 12 · 2023: 15 · 2022: 11 · 2021: 16 · 2020: 19 · 2019: 27 · 2018: 17 · 2017: 18 · 2016: 17 · 2015: 23 · 2014: 29 · 2013: 23 · 2012: 23
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (P01AG009973)
- National Institute of Mental Health (R01MH052090)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- recollection, familiarity, recognition memory, hippocampus, signal detection theory, receiver operating characteristic, rats
- MeSH terms
- Animals, Hippocampus, Humans, Language, Male, Odorants, Mental Recall, Smell, Bias, Rats, Long-Evans, Rats
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