Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear
Abstract
Anxiety disorders, characterized by anxiety and fearfulness, are found to be able to cause abnormal emotional responses' associated with memories of negative events, which implicate pressure on society with an increasingly large burden. Better treatment has been of concern to the community. Venlafaxine (VEN), a nonclassical antidepressant agent, is applied in the treatment of social phobia, major depression (MD) and general anxiety disorder (GAD) and, to a certain extent, posttraumatic stress disorder (PTSD), which improves working memory and spatial memory as well as ameliorates emotion by affecting specified brain regions. In this study, we committed to seek a new way for using VEN on treatment of anxiety disorders. To investigate the effect of VEN on extinction of auditory-cue conditioned fear, conditioned rats received a treatment with VEN before extinction training and tests for freezing level of within-session and between-session extinction. To investigate the effect of VEN on reinstatement, all conditioned rats received a treatment with VEN over a period for 21 days. After a rest for 7 days, two tests for freezing level were conducted. We found that: (1) VEN (40mg/kg) treatment at 30min prior to extinction training significantly facilitated the between-session extinction, but not the within-session extinction; (2) chronic administration with VEN (40mg/kg) prevented the return of extinguished auditory-cue fear. These data elucidate the critical role of VEN in auditory-cue fear memory, suggesting that VEN may be an ideal choice for the exposure-based drug treatment and maintenance treatment in patients with GAD, SAD and PTSD.
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Pre-clinical rodent studies have shown that venlafaxine and fluoxetine can prevent reinstatement of conditioned fear.
“Pre-clinical rodent studies have shown that monoaminergic specific antidepressants such as venlafaxine (serotonin–norepinephrine reuptake inhibitor; SNRI) and fluoxetine (serotonin specific reuptake inhibitor; SSRI) can facilitate between-session extinction (79, 80) and prevent reinstatement of conditioned fear (80, 81).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [80]
Pre-clinical rodent studies have shown that venlafaxine (an SNRI) and fluoxetine (an SSRI) can facilitate between-session extinction of conditioned fear.
“Pre-clinical rodent studies have shown that monoaminergic specific antidepressants such as venlafaxine (serotonin–norepinephrine reuptake inhibitor; SNRI) and fluoxetine (serotonin specific reuptake inhibitor; SSRI) can facilitate between-session extinction (79, 80) and prevent reinstatement of conditioned fear (80, 81).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [80]
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- Authors
- Yang, C.-H., Shi, H.-S., Zhu, W.-L., Wu, P., Sun, L.-L., Si, J.-J., Liu, M.-M., Zhang, Y., Suo, L., & Yang, J.-L.
- Affiliations
- Peking University (CN)
- Tianjin Anding Hospital (CN)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 230
- Issue
- 1
- Pages
- 268-273
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2021603453
- Cited by
- 25
- References
- 42
- Citations by year
- 2025: 1 · 2023: 1 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30870895)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- venlafaxine, fear reinstatement, anxiety disorders, generalized anxiety disorder, social anxiety disorder, post-traumatic stress disorder, fear memory, extinction training, antidepressants
- MeSH terms
- Venlafaxine Hydrochloride, Acoustic Stimulation, Animals, Anxiety Disorders, Conditioning, Psychological, Cues, Cyclohexanols, Disease Models, Animal, Dose-Response Relationship, Drug, Extinction, Psychological, Fear, Male, Motor Activity, Time Factors, Rats, Sprague-Dawley, Antidepressive Agents, Second-Generation, Rats
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