Induction of Fear Extinction with Hippocampal-Infralimbic BDNF
Open accessAbstract
Pharmacological Forgetting: Extinction of conditioned fear forms a new memory in the infralimbic medial prefrontal cortex that is critical for subsequent retrieval of the extinction memory. Understanding the mechanisms that underlie this extinction-related plasticity could help in the treatment of anxiety disorders. By infusing BDNF (brain-derived neurotrophic factor) into the infralimbic cortex, Peters et al. (p. 1288 ) caused the extinction of conditioned fear, even without an extinction trial. In fact, BDNF infusion seemed to act as if an extinction training session had been given. Thus, the hippocampus is a likely source of the BDNF input to the infralimbic cortex, and individual differences in extinction memory may reflect variations in hippocampal BDNF content.
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Both the consolidation of new memory and extinction require BDNF.
“both the consolidation of new memory and extinction requires BDNF (Lee et al., 2004; Peters et al., 2010)”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Peters et al., 2010
The paper’s introductory discussion (page unavailable in our copy) calls BDNF a major mediator of memory consolidation. Its rat experiments show that BDNF strengthens extinction memory and that augmenting it can prevent extinction failure. These findings support a role for BDNF in both processes, but do not establish the unqualified claim that both require it. (LLM, conf=0.86)
Experimental — accuracy not yet measuredInfusion of Bdnf into IL after threat acquisition is sufficient to diminish threat responses in the absence of extinction training.
“infusion of Bdnf into IL after threat acquisition is sufficient to diminish threat responses in the absence of extinction training [60].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [60]
Direct administration of BDNF into the rodent brain alleviates several depressive phenotypes, curbs addiction, and enhances fear extinction.
“direct administration of BDNF into the rodent brain has been shown to alleviate several depressive phenotypes, curb addiction, and enhance fear extinction (130–133)”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [133]
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- Authors
- Peters, J., Dieppa-Perea, L. M., Melendez, L. M., & Quirk, G. J.
- Affiliations
- University of Puerto Rico, Medical Sciences Campus (PR)
- Department of Microbiology, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA.
- Corresponding author
- Quirk, Gregory J.
- Venue
- Science
- Published
- 2010-06-04
- Volume
- 328
- Issue
- 5983
- Pages
- 1288-1290
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3570764
- OpenAlex
- W2071580102
- Cited by
- 462
- References
- 5
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 27 · 2023: 20 · 2022: 23 · 2021: 39 · 2020: 25 · 2019: 28 · 2018: 34 · 2017: 31 · 2016: 25 · 2015: 40 · 2014: 36 · 2013: 33 · 2012: 27
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health (5r01mh081975-05)
- National Institute of Mental Health (MH085383, MH-058883, MH083516, R01-MH081975, F32MH085383, R01MH058883, R37MH058883, MH081975, R29MH058883, R01MH083516)
- National Institute of Neurological Disorders and Stroke (NS043011, U54NS043011)
- National Center for Research Resources (RR003051, G12RR003051)
- National Institute on Minority Health and Health Disparities (G12MD007600)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear extinction, brain-derived neurotrophic factor, hippocampus, auditory fear conditioning, NMDA receptor, synaptic plasticity, conditioned fear memory
- MeSH terms
- Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Hippocampus, Humans, Male, Memory, Neural Pathways, Piperazines, Recombinant Proteins, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Excitatory Amino Acid Antagonists, Brain-Derived Neurotrophic Factor, Rats
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