Cited by 115Bioactive Compounds in PlantsAlzheimer's disease research and treatmentsAntioxidants, Aging, Portulaca oleracea

Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-Accelerated Mouse

Nakajima, Akira, Aoyama, Yuki, Nguyen, Thuy-Ty Lan, Shin, Eun-Joo, Kim, Hyoung-Chun, Yamada, Shinnosuke, Nakai, Tsuyoshi, Nagai, Taku +4 more·2013·Behavioural Brain Research

Abstract

Senescence-accelerated mouse prone 8 (SAMP8) is a model of aging characterized by the early onset of learning and memory impairment and various pathological features of Alzheimer's disease (AD). Our recent studies have demonstrated that nobiletin, a polymethoxylated flavone from citrus peels, ameliorates learning and memory impairment in olfactory-bulbectomized mice, amyloid precursor protein transgenic mice, and NMDA receptor antagonist-treated mice. Here, we present evidence that this natural compound improves age-related cognitive impairment and reduces oxidative stress and tau phosphorylation in SAMP8 mice. Treatment with nobiletin (10 or 50mg/kg) reversed the impairment of recognition memory and context-dependent fear memory in SAMP8 mice. Treatment with nobiletin also restored the decrease in the GSH/GSSG ratio in the brain of SAMP8 mice. In addition, increases in glutathione peroxidase and manganese-superoxide dismutase activities, as well as a decrease in protein carbonyl level, were observed in the brain of nobiletin-treated SAMP8 mice. Furthermore, nobiletin reduced tau phosphorylation in the hippocampus of SAMP8 mice. Together, the markedly beneficial effects of nobiletin represent a potentially useful treatment for ameliorating the learning and memory deficits, oxidative stress, and hyperphosphorylation of tau in aging as well as age-related neurodegenerative diseases such as AD.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2013.05.025

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Nobiletin attenuates senescence-related cognitive deficits in SAMP8 mice by counteracting amyloid ß accumulation in the brain.

    “One of these, nobiletin, was demonstrated to attenuate senescence-related cognitive deficits in SAMP8 mice by counteracting amyloid ß accumulation in the brain [302,303].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nakajima, A., Aoyama, Y., Nguyen, T.-T. L., Shin, E.-J., Kim, H.-C., Yamada, S., Nakai, T., Nagai, T., Yokosuka, A., Mimaki, Y., Ohizumi, Y., & Yamada, K.
Affiliations
  • Nagoya University (JP)
  • Kangwon National University (KR)
  • Tokyo University of Pharmacy and Life Sciences (JP)
  • Shizuoka University (JP)
Corresponding author
Yamada, Kiyofumi
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2013-08
Volume
250
Pages
351-360
ISSN
0166-4328 (ISSN-L)
OpenAlex
W1975692706
Cited by
115
References
78
Citations by year
2026: 5 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 14 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 15 · 2017: 14 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 1
FWCI
8.04
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology (22390046, 23659135, 23790290, 24111518)
  • Ministry of Agriculture, Forestry and Fisheries
  • Smoking Research Foundation (2012k001115)
  • Ministry of Science and Technology, Croatia
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
nobiletin, citrus flavonoids, SAMP8 mice, aging, age-related cognitive impairment, Alzheimer's disease, tau hyperphosphorylation, oxidative stress, glutathione, glutathione peroxidase, manganese superoxide dismutase, protein carbonylation, recognition memory, fear memory, hippocampus, neuroprotection
MeSH terms
Aging, Analysis of Variance, Animals, Antioxidants, Body Weight, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Fear, Glutathione, Glutathione Peroxidase, Male, Mice, Transgenic, Phosphorylation, Superoxide Dismutase, Case-Control Studies, tau Proteins, Oxidative Stress, Maze Learning, Flavones, Protein Carbonylation, Lipid Metabolism, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review