Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-Accelerated Mouse
Abstract
Senescence-accelerated mouse prone 8 (SAMP8) is a model of aging characterized by the early onset of learning and memory impairment and various pathological features of Alzheimer's disease (AD). Our recent studies have demonstrated that nobiletin, a polymethoxylated flavone from citrus peels, ameliorates learning and memory impairment in olfactory-bulbectomized mice, amyloid precursor protein transgenic mice, and NMDA receptor antagonist-treated mice. Here, we present evidence that this natural compound improves age-related cognitive impairment and reduces oxidative stress and tau phosphorylation in SAMP8 mice. Treatment with nobiletin (10 or 50mg/kg) reversed the impairment of recognition memory and context-dependent fear memory in SAMP8 mice. Treatment with nobiletin also restored the decrease in the GSH/GSSG ratio in the brain of SAMP8 mice. In addition, increases in glutathione peroxidase and manganese-superoxide dismutase activities, as well as a decrease in protein carbonyl level, were observed in the brain of nobiletin-treated SAMP8 mice. Furthermore, nobiletin reduced tau phosphorylation in the hippocampus of SAMP8 mice. Together, the markedly beneficial effects of nobiletin represent a potentially useful treatment for ameliorating the learning and memory deficits, oxidative stress, and hyperphosphorylation of tau in aging as well as age-related neurodegenerative diseases such as AD.
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Nobiletin attenuates senescence-related cognitive deficits in SAMP8 mice by counteracting amyloid ß accumulation in the brain.
“One of these, nobiletin, was demonstrated to attenuate senescence-related cognitive deficits in SAMP8 mice by counteracting amyloid ß accumulation in the brain [302,303].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [302]
Cites
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
Paglia, D. E., & Valentine, W. N. (1967) · PubMed · Cited by 10,776 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,106 · see citing works
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
Li, J. W.-H., & Vederas, J. C. (2009) · Science · doi:10.1126/science.1168243 · Cited by 2,056 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · see citing works
Age-related changes in oxidized proteins.
Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works
Reed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, W. W., & Potter, D. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90118-9 · Cited by 1,178 · see citing works
Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903 · see citing works
Bains, J. S., & Shaw, C. A. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00045-3 · Cited by 716 · see citing works
Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657 · see citing works
Tau phosphorylation in neuronal cell function and dysfunction
Johnson, G. V. W., & Stoothoff, W. H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01558 · Cited by 624 · see citing works
Proline-directed and non-proline-directed phosphorylation of PHF-tau
Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Titani, K., & Ihara, Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.823 · Cited by 557 · see citing works
Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504 · see citing works
Forster, M. J., Dubey, A., Dawson, K. M., Stutts, W. A., Lal, H., & Sohal, R. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4765 · Cited by 494 · see citing works
On the delay-dependent involvement of the hippocampus in object recognition memory
HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works
Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., Butterfield, D. A., & Morley, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01580.x · Cited by 459 · see citing works
Goedert, M., Jakes, R., Crowther, R. A., Six, J., Lübke, U., Vandermeeren, M., Cras, P., Trojanowski, J. Q., & Lee, V. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5066 · Cited by 446 · see citing works
Kondo, T., Reaume, A. G., Huang, T., Carlson, E. J., Murakami, K., Chen, S. F., Hoffman, E. K., Scott, R. W., Epstein, C. J., & Chan, P. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04180.1997 · Cited by 429 · see citing works
Measurement of Oxidized/Reduced Glutathione Ratio
Owen, J. B., & Butterfield, D. A. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_18 · Cited by 411 · see citing works
Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
Miyamoto, M., Kiyota, Y., Yamazaki, N., Nagaoka, A., Matsuo, T., Nagawa, Y., & Takeda, T. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90112-5 · Cited by 375 · see citing works
Butterfield, D. A., & Poon, H. F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.05.007 · Cited by 328 · see citing works
Winters, B. D., & Bussey, T. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3827-04.2005 · Cited by 283 · see citing works
Cho, J., & Johnson, G. V. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02155.x · Cited by 282 · see citing works
Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration
Alonso, A. D., Di Clerico, J., Li, B., Corbo, C. P., Alaniz, M. E., Grundke-Iqbal, I., & Iqbal, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110957 · Cited by 236 · see citing works
Takeda, T. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9922-y · Cited by 233 · see citing works
Butterfield, D. A., Howard, B. J., Yatin, S. M., Allen, K. L., & Carney, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.674 · Cited by 231 · see citing works
Behavioral abnormality and pharmacologic response in social isolation-reared mice
Koike, H., Ibi, D., Mizoguchi, H., Nagai, T., Nitta, A., Takuma, K., Nabeshima, T., Yoneda, Y., & Yamada, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.028 · Cited by 221 · see citing works
Self-citationOnozuka, H., Nakajima, A., Matsuzaki, K., Shin, R., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., Sashida, Y., Mimaki, Y., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.140293 · Cited by 220 · see citing works
Self-citationβ-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory
Morley, J. E., Kumar, V. B., Bernardo, A. E., Farr, S. A., Uezu, K., Tumosa, N., & Flood, J. F. (2000) · Peptides · doi:10.1016/s0196-9781(00)00342-9 · Cited by 219 · see citing works
Kumar, V. B., Farr, S. A., Flood, J. F., Kamlesh, V., Franko, M. W., Banks, W. A., & Morley, J. E. (2000) · Peptides · doi:10.1016/s0196-9781(00)00339-9 · Cited by 193 · see citing works
Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works
Li, Q., Zhao, H., Zhang, Z. F., Liu, Z. G., Pei, X., Wang, J. B., & Li, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.014 · Cited by 165 · see citing works
Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., & Ohizumi, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.001 · Cited by 151 · see citing works
Self-citationHyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
Canudas, A. M., Cuesta, J., Rodríguez, M. I., Acuña-Castroviejo, D., Sureda, F. X., Camins, A., & Pallàs, M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.07.008 · Cited by 142 · see citing works
Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI
Ewers, M., Büerger, K., Teipel, S. J., Scheltens, P., Schröder, J., Zinkowski, R. P., Bouwman, F. H., Schönknecht, P., Schoonenboom, N. S. M., Andreasen, N. C., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000286944.22262.ff · Cited by 142 · see citing works
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood
Ibi, D., Nagai, T., Koike, H., Kitahara, Y., Mizoguchi, H., Niwa, M., Jaaro-Peled, H., Nitta, A., Yoneda, Y., & Nabeshima, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.027 · Cited by 137 · see citing works
Self-citationNakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Song, S.-Y., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A., Mimaki, Y., et al. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.sc0070155 · Cited by 137 · see citing works
Self-citationMatsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A. M., Shido, O., Mimaki, Y., Sashida, Y., & Ohizumi, Y. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.077 · Cited by 135 · see citing works
Self-citationYamamoto, Y., Shioda, N., Han, F., Moriguchi, S., Nakajima, A., Yokosuka, A., Mimaki, Y., Sashida, Y., Yamakuni, T., Ohizumi, Y., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.081 · Cited by 128 · see citing works
Self-citationRudrabhatla, P., Jaffe, H., & Pant, H. C. (2011) · The FASEB Journal · doi:10.1096/fj.11-181297 · Cited by 121 · see citing works
Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells
Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A. W., et al. (2005) · Biochemistry · doi:10.1021/bi050643x · Cited by 120 · see citing works
Self-citationMelatonin Reduces Oxidative Damage of Neural Lipids and Proteins in Senescence-Accelerated Mouse
Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00005-2 · Cited by 112 · see citing works
Shin, E., Ko, K. H., Kim, W.-K., Chae, J. S., Yen, T. P. H., Kim, H. J., Wie, M., & Kim, H. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.12.003 · Cited by 103 · see citing works
Self-citationMagnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice
Matsui, N., Takahashi, K., Takeichi, M., Kuroshita, T., Noguchi, K., Yamazaki, K., Tagashira, H., Tsutsui, K., Okada, H., Kido, Y., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.107 · Cited by 103 · see citing works
Pathological Substrates of Cognitive Decline in Alzheimer’s Disease
Giannakopoulos, P., Kövari, E., Gold, G., von Gunten, A., Hof, P. R., & Bouras, C. (2009) · Frontiers of Neurology and Neuroscience · doi:10.1159/000197881 · Cited by 101 · see citing works
Senescence-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain
Miyamoto, M., Kiyota, Y., Nishiyama, M., & Nagaoka, A. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90081-c · Cited by 96 · see citing works
Age-related defects in lifespan and learning ability in SAMP8 mice
Nomura, Y., & Okuma, Y. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00006-8 · Cited by 93 · see citing works
Ansari, M. A., Gururaj Joshi, A., Huang, Q., Opii, W. O., Abdul, H. M., Rukhsana Sultana, A., & Butterfield, D. A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.002 · Cited by 92 · see citing works
Lü, Y., Su, M.-Y., Hai-ya, H., Lin-li, & Yuan, C.-G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.078 · Cited by 89 · see citing works
Gong, Y.-S., Liu, L., Xie, B., Liao, Y., Yang, E.-L., & Sun, Z. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.029 · Cited by 88 · see citing works
Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence
Tomobe, K., & Nomura, Y. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9923-x · Cited by 83 · see citing works
Biochemical changes related to aging in the senescence-accelerated mouse
Nomura, Y., Wang, B.-X., Qi, S.-B., Namba, T., & Kaneko, S. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90034-x · Cited by 76 · see citing works
Shin, E., Duong, C., Nguyen, X. T., Li, Z., Bing, G., Bach, J., Park, D.-H., Nakayama, K. I., Ali, S. F., Kanthasamy, A., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.001 · Cited by 76 · see citing works
Self-citationYasui, F., Matsugo, S., Ishibashi, M., Kajita, T., Ezashi, Y., Oomura, Y., Kojo, S., & Sasaki, K. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01127-8 · Cited by 75 · see citing works
N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria
Martı́nez, M., Hernández, A. I., & Martínez-Banaclocha, N. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02349-5 · Cited by 72 · see citing works
Nakajima, A., Yamakuni, T., Matsuzaki, K., Nakata, N., Onozuka, H., Yokosuka, A., Sashida, Y., Mimaki, Y., & Ohizumi, Y. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.117010 · Cited by 71 · see citing works
Self-citationObara, Y., Aoki, T., Kusano, M., & Ohizumi, Y. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.803 · Cited by 70 · see citing works
Self-citationMaurice, T., Roman, F. J., Su, T., & Privat, A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00565-3 · Cited by 69 · see citing works
Ohizumi, Y. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.73.263 · Cited by 62 · see citing works
Self-citationNishikawa, T., Takahashi, J. A., Fujibayashi, Y., Fujisawa, H., Zhu, B., Nishimura, Y., Ohnishi, K., Higuchi, K., Hashimoto, N., & Hosokawa, M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00646-6 · Cited by 56 · see citing works
Jeng-Dian, S., Yen, J.-H., Li, S., Weng, C., Lin, M.-H., Ho, C., & Wu, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.002 · Cited by 56 · see citing works
Saigusa, D., Shibuya, M., Jinno, D., Yamakoshi, H., Iwabuchi, Y., Yokosuka, A., Mimaki, Y., Naganuma, A., Ohizumi, Y., Tomioka, Y., et al. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5031-2 · Cited by 53 · see citing works
Self-citationSartori, S. B., Hauschild, M., Bunck, M., Gaburro, S., Landgraf, R., & Singewald, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016849 · Cited by 52 · see citing works
Shin, E., Jeong, J. H., Bing, G., Park, E. S., Chae, J. S., Yen, T. P. H., Kim, W.-K., Wie, M., Jung, B.-D., Kim, H. J., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.014 · Cited by 52 · see citing works
Self-citationHe, X.-L., Zhou, W.-Q., Ming-gang, B., & Du, G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.084 · Cited by 50 · see citing works
Kim, H., Bing, G., Jhoo, W., Kim, W.-K., Shin, E., Park, E.-S., Choi, Y.-S., Lee, D., Shin, C. Y., Ryu, J. R., et al. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00382-5 · Cited by 49 · see citing works
Self-citationBrain lipid hydroperoxide level increases in senescence-accelerated mice at an early age
Yasui, F., Ishibashi, M., Matsugo, S., Kojo, S., Oomura, Y., & Sasaki, K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00827-9 · Cited by 48 · see citing works
Han, D., Qureshi, H. Y., Lu, Y., & Paudel, H. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901095200 · Cited by 40 · see citing works
Ohta, A., Akiguchi, I., Seriu, N., Ohnishi, K., Yagi, H., Higuchi, K., & Hosokawa, M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00206-8 · Cited by 32 · see citing works
Zhao, Q., Yokozawa, T., Yamabe, N., et al. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.07.016 · Cited by 32 · see citing works
Ohizumi, Y. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.60.263 · Cited by 26 · see citing works
Self-citationSian, J., Dexter, D. T., Cohen, G., et al. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06807.x · Cited by 20 · see citing works
Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Oh‐ishi, S., Haga, S., & Ohno, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.008 · Cited by 12 · see citing works
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Nakajima, A., Aoyama, Y., Shin, E.-J., Nam, Y., Kim, H.-C., Nagai, T., Yokosuka, A., Mimaki, Y., Yokoi, T., Ohizumi, Y., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.028 · Cited by 138 · see citing works
Self-citationHoyt, K. R., & Obrietan, K. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00537-9 · Cited by 77 · see citing works
- Authors
- Nakajima, A., Aoyama, Y., Nguyen, T.-T. L., Shin, E.-J., Kim, H.-C., Yamada, S., Nakai, T., Nagai, T., Yokosuka, A., Mimaki, Y., Ohizumi, Y., & Yamada, K.
- Affiliations
- Nagoya University (JP)
- Kangwon National University (KR)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Shizuoka University (JP)
- Corresponding author
- Yamada, Kiyofumi
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 250
- Pages
- 351-360
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1975692706
- Cited by
- 115
- References
- 78
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 14 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 15 · 2017: 14 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 1
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology (22390046, 23659135, 23790290, 24111518)
- Ministry of Agriculture, Forestry and Fisheries
- Smoking Research Foundation (2012k001115)
- Ministry of Science and Technology, Croatia
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- nobiletin, citrus flavonoids, SAMP8 mice, aging, age-related cognitive impairment, Alzheimer's disease, tau hyperphosphorylation, oxidative stress, glutathione, glutathione peroxidase, manganese superoxide dismutase, protein carbonylation, recognition memory, fear memory, hippocampus, neuroprotection
- MeSH terms
- Aging, Analysis of Variance, Animals, Antioxidants, Body Weight, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Fear, Glutathione, Glutathione Peroxidase, Male, Mice, Transgenic, Phosphorylation, Superoxide Dismutase, Case-Control Studies, tau Proteins, Oxidative Stress, Maze Learning, Flavones, Protein Carbonylation, Lipid Metabolism, Mice
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