Nobiletin, a Citrus Flavonoid, Improves Cognitive Impairment and Reduces Soluble Aβ Levels in a Triple Transgenic Mouse Model of Alzheimer’s Disease (3XTg-AD)

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Glutathione peroxidase activity in selenium-deficient rat liver

Lawrence, R. A., & Burk, R. F. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90747-6 · Cited by 3,544 · see citing works

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

Li, J. W.-H., & Vederas, J. C. (2009) · Science · doi:10.1126/science.1168243 · Cited by 2,056 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

Alzheimer Mechanisms and Therapeutic Strategies

Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980 · see citing works

The neurobiological basis of spontaneous alternation

Lalonde, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00041-0 · Cited by 842 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536 · see citing works

On the delay-dependent involvement of the hippocampus in object recognition memory

HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.012 · Cited by 343 · see citing works

Synaptic changes in Alzheimer’s disease and its models

Pozueta, J., Lefort, R., & Shelanski, M. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.050 · Cited by 305 · see citing works

Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

Clinton, L. K., Billings, L. M., Green, K. N., Caccamo, A., Ngo, J., Oddo, S., McGaugh, J. L., & LaFerla, F. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.013 · Cited by 299 · see citing works

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

Hirata-Fukae, C., Li, H.-F., Hoe, H.-S., Gray, A. J., Minami, S. S., Hamada, K., Niikura, T., Hua, F., Tsukagoshi-Nagai, H., Horikoshi-Sakuraba, Y., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.079 · Cited by 284 · see citing works

Transient Inactivation of Perirhinal Cortex Disrupts Encoding, Retrieval, and Consolidation of Object Recognition Memory

Winters, B. D., & Bussey, T. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3827-04.2005 · Cited by 283 · see citing works

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

Carroll, J. C., Rosario, E. R., Kreimer, S., Villamagna, A., Gentzschein, E., Stanczyk, F. Z., & Pike, C. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.009 · Cited by 273 · see citing works

Oxidation of glutathione during hydroperoxide metabolism

Eklöw, L., Moldéus, P., & Orrenius, S. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb07938.x · Cited by 246 · see citing works

Behavioral abnormality and pharmacologic response in social isolation-reared mice

Koike, H., Ibi, D., Mizoguchi, H., Nagai, T., Nitta, A., Takuma, K., Nabeshima, T., Yoneda, Y., & Yamada, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.028 · Cited by 221 · see citing works

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Onozuka, H., Nakajima, A., Matsuzaki, K., Shin, R., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., Sashida, Y., Mimaki, Y., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.140293 · Cited by 220 · see citing works

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice

NELSON, R., GUO, Z., HALAGAPPA, V, PEARSON, M., GRAY, A., MATSUOKA, Y., BROWN, M., MARTIN, B., IYUN, T., & MAUDSLEY, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.037 · Cited by 173 · see citing works

Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities

Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., & Ohizumi, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.001 · Cited by 151 · see citing works

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

Filali, M., Lalonde, R., Thériault, P., Julien, C., Calon, F., & Planel, E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.004 · Cited by 139 · see citing works

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood

Ibi, D., Nagai, T., Koike, H., Kitahara, Y., Mizoguchi, H., Niwa, M., Jaaro-Peled, H., Nitta, A., Yoneda, Y., & Nabeshima, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.027 · Cited by 137 · see citing works

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Nakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Song, S.-Y., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A., Mimaki, Y., et al. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.sc0070155 · Cited by 137 · see citing works

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood

Ibi, D., Nagai, T., Kitahara, Y., Mizoguchi, H., Koike, H., Shiraki, A., Takuma, K., Kamei, H., Noda, Y., Nitta, A., et al. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.03.015 · Cited by 135 · see citing works

Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats

Matsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A. M., Shido, O., Mimaki, Y., Sashida, Y., & Ohizumi, Y. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.077 · Cited by 135 · see citing works

Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers

Florent‐Béchard, S., Malaplate, C., Youssef, I., Kriem, B., Koziel, V., Escanyé, M., Fifre, A., Sponne, I., Leininger‐Muller, B., Olivier, J. L., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03541.x · Cited by 131 · see citing works

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

Yamamoto, Y., Shioda, N., Han, F., Moriguchi, S., Nakajima, A., Yokosuka, A., Mimaki, Y., Sashida, Y., Yamakuni, T., Ohizumi, Y., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.081 · Cited by 128 · see citing works

Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells

Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A. W., et al. (2005) · Biochemistry · doi:10.1021/bi050643x · Cited by 120 · see citing works

Indirect detection of photosensitizer ex vivo

Bourré, L., Thibaut, S., Briffaud, A., Rousset, N., Eléouet, S., Lajat, Y., & Patrice, T. (2002) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(02)00279-8 · Cited by 118 · see citing works

Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-Accelerated Mouse

Nakajima, A., Aoyama, Y., Nguyen, T.-T. L., Shin, E.-J., Kim, H.-C., Yamada, S., Nakai, T., Nagai, T., Yokosuka, A., Mimaki, Y., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.025 · Cited by 115 · see citing works

Ginsenoside Re Rescues Methamphetamine-Induced Oxidative Damage, Mitochondrial Dysfunction, Microglial Activation, and Dopaminergic Degeneration by Inhibiting the Protein Kinase Cδ Gene

Shin, E., Shin, S. W., Nguyen, T. L., Park, D. H., Wie, M., Jang, C., Nah, S.-Y., Yang, B. W., Ko, S. K., Nabeshima, T., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8617-1 · Cited by 112 · see citing works

Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats

Shin, E., Ko, K. H., Kim, W.-K., Chae, J. S., Yen, T. P. H., Kim, H. J., Wie, M., & Kim, H. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.12.003 · Cited by 103 · see citing works

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Onishi, T., Iwashita, H., Uno, Y., Kunitomo, J., Saitoh, M., Kimura, E., Fujita, H., Uchiyama, N., Kori, M., & Takizawa, M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07532.x · Cited by 91 · see citing works

Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide

Lü, Y., Su, M.-Y., Hai-ya, H., Lin-li, & Yuan, C.-G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.078 · Cited by 89 · see citing works

Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor

NAKAI, T., Nagai, T., Tanaka, M., Itoh, N., Asai, N., Enomoto, A., Asai, M., Yamada, S., Saifullah, A. B., Sokabe, M., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2228-14.2014 · Cited by 88 · see citing works

Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ

Shin, E., Duong, C., Nguyen, X. T., Li, Z., Bing, G., Bach, J., Park, D.-H., Nakayama, K. I., Ali, S. F., Kanthasamy, A., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.001 · Cited by 76 · see citing works

Cognitive and emotional profiles of aged Alzheimer's disease (3×TgAD) mice: effects of environmental enrichment and sexual dimorphism.

Blázquez, G., Cañete, T., Tobeña, A., Giménez-Llort, L., & Fernández-Teruel, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.008 · Cited by 74 · see citing works

Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment Associated with N-Methyl-D-aspartate Receptor Antagonism by Activation of Extracellular Signal-Regulated Kinase Signaling

Nakajima, A., Yamakuni, T., Matsuzaki, K., Nakata, N., Onozuka, H., Yokosuka, A., Sashida, Y., Mimaki, Y., & Ohizumi, Y. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.117010 · Cited by 71 · see citing works

β-Eudesmol Induces Neurite Outgrowth in Rat Pheochromocytoma Cells Accompanied by an Activation of Mitogen-Activated Protein Kinase

Obara, Y., Aoki, T., Kusano, M., & Ohizumi, Y. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.803 · Cited by 70 · see citing works

Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies

Nakajima, A., Ohizumi, Y., & Yamada, K. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.2.75 · Cited by 64 · see citing works

Application of Physiologically Active Substances Isolated from Natural Resources to Pharmacological Studies.

Ohizumi, Y. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.73.263 · Cited by 62 · see citing works

3′,4′-Didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells

Jeng-Dian, S., Yen, J.-H., Li, S., Weng, C., Lin, M.-H., Ho, C., & Wu, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.002 · Cited by 56 · see citing works

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

Saigusa, D., Shibuya, M., Jinno, D., Yamakoshi, H., Iwabuchi, Y., Yokosuka, A., Mimaki, Y., Naganuma, A., Ohizumi, Y., Tomioka, Y., et al. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5031-2 · Cited by 53 · see citing works

Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice

Shin, E., Jeong, J. H., Bing, G., Park, E. S., Chae, J. S., Yen, T. P. H., Kim, W.-K., Wie, M., Jung, B.-D., Kim, H. J., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.014 · Cited by 52 · see citing works

Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment

Kim, H., Bing, G., Jhoo, W., Kim, W.-K., Shin, E., Park, E.-S., Choi, Y.-S., Lee, D., Shin, C. Y., Ryu, J. R., et al. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00382-5 · Cited by 49 · see citing works

Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines

Nemoto, K., Ikeda, A., Yoshida, C., Kimura, J., Mori, J., Fujiwara, H., Yokosuka, A., Mimaki, Y., Ohizumi, Y., & Degawa, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.024 · Cited by 29 · see citing works

Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells

Ikeda, A., Nemoto, K., Yoshida, C., Miyata, S., Mori, J., Soejima, S., Yokosuka, A., Mimaki, Y., Ohizumi, Y., & Degawa, M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.004 · Cited by 20 · see citing works

Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells

Fujiwara, H., Kimura, J., Sakamoto, M., Yokosuka, A., Mimaki, Y., Murata, K., Yamaguchi, K., & Ohizumi, Y. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0440 · Cited by 18 · see citing works

Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task.

Yamada, K., Nakayama, S., Shiotani, T., Hasegawa, T., & NABESHIMA, T. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22556-3 · Cited by 15 · see citing works

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523 · see citing works

Citrus flavonoids and their antioxidant evaluation

Wang, Y., Liu, X., Chen, J., Cao, J., Li, X., & Sun, C. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1870035 · Cited by 259 · see citing works

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Nakajima, A., & Ohizumi, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143380 · Cited by 239 · see citing works

The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Maher, P. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123056 · Cited by 232 · see citing works

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203 · see citing works

Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones

Gao, Z., Gao, W., Zeng, S.-L., Li, P., & Liu, E. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.11.036 · Cited by 185 · see citing works

Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease

Braidy, N., Behzad, S., Habtemariam, S., Ahmed, T., Daglia, M., Nabavi, S. M., Sobarzo‐Sánchez, E., & Nabavi, S. F. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170328113309 · Cited by 158 · see citing works

Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2076064 · Cited by 156 · see citing works

The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro

Huang, H., Li, L., Shi, W., Liu, H., Yang, J., Yuan, X., & Wu, L. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2918796 · Cited by 151 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

Cirmi, S., Ferlazzo, N., Lombardo, G. E., Ventura-Spagnolo, E., Gangemi, S., Calapai, G., & Navarra, M. (2016) · Molecules · doi:10.3390/molecules21101312 · Cited by 129 · see citing works

Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Devi, S., Kumar, V., Singh, S. K., Dubey, A. K., & Kim, J.-J. (2021) · Biomedicines · doi:10.3390/biomedicines9020099 · Cited by 124 · see citing works

Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

Zhang, R., Chen, J., Mao, L., Guo, Y., Hao, Y., Deng, Y., Han, X., Li, Q., Liao, W., & Yuan, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07908 · Cited by 117 · see citing works

Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing

Howes, M. R., Perry, N. S. L., Londoño, C. A. V., & Perry, E. K. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14898 · Cited by 99 · see citing works

Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways

Qi, G., Mi, Y., Fan, R., Li, R., Liu, Z., & Liu, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00133 · Cited by 95 · see citing works

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Dhakal, S., Kushairi, N., Phan, C., Adhikari, B., Sabaratnam, V., & Macreadie, I. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205090 · Cited by 89 · see citing works

Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

Hoyt, K. R., & Obrietan, K. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00537-9 · Cited by 77 · see citing works

Alzheimer Disease: Clues from traditional and complementary medicine

Cooper, E. L., & Ma, M. J. (2017) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2016.12.003 · Cited by 76 · see citing works

Enhancement of Anti-Inflammatory Properties of Nobiletin in Macrophages by a Nano-Emulsion Preparation

Liao, W., Liu, Z., Zhang, T., Sun, S., Ye, J., Li, Z., Mao, L., & Ren, J. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03953 · Cited by 76 · see citing works

Therapeutic benefits of flavonoids against neuroinflammation: a systematic review

Hamsalakshmi, Alex, A. M., Marappa, M. A., Joghee, S., & Chidambaram, S. B. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00895-8 · Cited by 73 · see citing works

Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma

do Nascimento, R. P., dos Santos, B. L., Amparo, J. A. O., Soares, J. R. P., da Silva, K. C., de Santana, M. R., Almeida, Á. M. A. N., da Silva, V. D. A., Costa, M. D. F. D., Ulrich, H., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010116 · Cited by 71 · see citing works

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Gloston, G. F., Yoo, S. H., & Chen, Z. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00100 · Cited by 73 · see citing works

Protective Effects of Flavonoids against Alzheimer’s Disease: Pathological Hypothesis, Potential Targets, and Structure–Activity Relationship

Li, J., Sun, M., Cui, X., & Li, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710020 · Cited by 70 · see citing works

A novel GLP‐1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

Li, T., Jiao, J., Hölscher, C., Wu, M., Zhang, J., Tong, J., Dong, X., Qu, X., Cao, Y., Cai, H., et al. (2018) · Hippocampus · doi:10.1002/hipo.22837 · Cited by 69 · see citing works

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L.-M., Wang, M., Chen, R., Chiu, H., Wu, J.-L., Shen, M., Chou, D., Sheu, J., Lin, K., & Lu, W. (2015) · Phytotherapy Research · doi:10.1002/ptr.5517 · Cited by 67 · see citing works

Artemether Activation of AMPK/GSK3 β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β- Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

Li, S., Zhao, X., Lazarovici, P., & Zheng, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1862437 · Cited by 67 · see citing works

Bidirectional interaction of nobiletin and gut microbiota in mice fed with a high-fat diet

Zhang, M., Zhang, X., Zhu, J., Zhao, D., Ma, Y.-Y., Li, D., Ho, C., & Huang, Q. (2021) · Food & Function · doi:10.1039/d1fo00126d · Cited by 63 · see citing works

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer’s Disease Model Neurons

Kimura, J., Shimizu, K., Kajima, K., Yokosuka, A., Mimaki, Y., Oku, N., & Ohizumi, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00364 · Cited by 62 · see citing works

Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux

Wu, X., Zheng, D.-C., Qin, Y., Liu, Z., Zhang, G., Zhu, X., Zeng, L., & Liang, Z. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.064 · Cited by 60 · see citing works

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

Wei, D., Zhang, G., Zhu, Z. G., Zheng, Y., Yan, F., Pan, C.-X., Wang, Z., Li, X., Wang, F., Meng, P., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00690 · Cited by 55 · see citing works

Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

Keshtkar, S., Kaviani, M., Jabbarpour, Z., Geramizadeh, B., Motevaseli, E., Nikeghbalian, S., Shamsaeefar, A., Motazedian, N., Al-Abdullah, I. H., Ghahremani, M. H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48262-6 · Cited by 53 · see citing works

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

Kim, E., Nohara, K., Wirianto, M., Escobedo, G., Lim, J. Y., Morales, R., Yoo, S.-H., & Chen, Z. (2021) · Biomolecules · doi:10.3390/biom11071004 · Cited by 51 · see citing works

Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels

Youn, K., Yu, Y., Lee, J., Jeong, W., Ho, C.-T., & Jun, M. (2017) · Nutrients · doi:10.3390/nu9090973 · Cited by 43 · see citing works

Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging

Martínez‐Coria, H., Arrieta‐Cruz, I., Juárez, R. G., & López-Valdés, H. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054297 · Cited by 51 · see citing works

Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties

Liu, J., Li, T., Zhong, G., Pan, Y., Gao, M., Su, S., Liang, Y., Ma, C., Liu, Y., Wang, Q., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115406 · Cited by 49 · see citing works

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

Matsuzaki, K., & Ohizumi, Y. (2021) · Nutrients · doi:10.3390/nu13010145 · Cited by 49 · see citing works

Citrus peels odyssey: From the waste bin to the lab bench to the dining table

Ademosun, A. O. (2022) · Applied Food Research · doi:10.1016/j.afres.2022.100083 · Cited by 48 · see citing works

Identification of the chemical compositions of Ponkan peel by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Yang, Y., Zhao, X., Pan, Y., & Zhou, Z. (2015) · Analytical Methods · doi:10.1039/c5ay02633d · Cited by 46 · see citing works

Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go

Prasanna, P., & Upadhyay, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00224 · Cited by 46 · see citing works

The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model

Wirianto, M., Wang, C., Kim, E., Koike, N., Gomez‐Gutierrez, R., Nohara, K., Escobedo, G., Choi, J. M., Han, C., Yagita, K., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101633r · Cited by 45 · see citing works

Nobiletin as a Molecule for Formulation Development: An Overview of Advanced Formulation and Nanotechnology-Based Strategies of Nobiletin

Kesharwani, S. S., Mallya, P., Kumar, V. A., Jain, V. K., Sharma, S., & Dey, S. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01767-0 · Cited by 44 · see citing works

Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease

Albadrani, H. M., Chauhan, P., Ashique, S., Babu, M. A., Iqbal, D., Almutary, A. G., Abomughaid, M. M., Kamal, M., Paiva‐Santos, A. C., Alsaweed, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116376 · Cited by 44 · see citing works

Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D

Santa, K., Kumazawa, Y., & Nagaoka, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032627 · Cited by 44 · see citing works

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Farihi, A., Bouhrim, M., Chigr, F., Elbouzidi, A., Bencheikh, N., Zrouri, H., Nasr, F. A., Parvez, M. K., Alahdab, A., & Ahami, A. O. T. (2023) · Medicina · doi:10.3390/medicina59101812 · Cited by 42 · see citing works

Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2′,3′,4′-trihydroxyflavone (2-D08)

Marsh, D. T., Das, S., Ridell, J., & Smid, S. D. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.05.041 · Cited by 42 · see citing works

From folk medicine to functional food: a review on the bioactive components and pharmacological properties of citrus peels

Ademosun, A. O., Oboh, G., Olasehinde, T. A., & Adeoyo, O. O. (2018) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-017-0292-8 · Cited by 42 · see citing works

Benefits of dietary polyphenols in Alzheimer’s disease

Gaamouch, F. E., Chen, F., Ho, L., Lin, H., Yuan, C., Wong, J., & Wang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1019942 · Cited by 41 · see citing works

The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism

El‐Maraghy, S. A., Reda, A., Essam, R. M., & Kortam, M. A. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01292-z · Cited by 39 · see citing works

Discovery of Nobiletin from Citrus Peel as a Potent Inhibitor of β-Amyloid Peptide Toxicity

Youn, K., Lee, S., & Jun, M. (2019) · Nutrients · doi:10.3390/nu11112648 · Cited by 39 · see citing works

Nobiletin from citrus peel: a promising therapeutic agent for liver disease-pharmacological characteristics, mechanisms, and potential applications

Cheng, Y., Feng, S., Sheng, C.-Q., Yang, C., & Li, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1354809 · Cited by 38 · see citing works

Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system

Murphy, K. E., Llewellyn, K., Wakser, S., Pontasch, J., Samanich, N., Flemer, M., Hensley, K., Kim, D., & Park, J. C. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001245 · Cited by 38 · see citing works

An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar ‘Ohta ponkan’ (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity

Nakajima, A., Nemoto, K., & Ohizumi, Y. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104670 · Cited by 38 · see citing works

Therapeutic Effects of Anthocyanins and Environmental Enrichment in R6/1 Huntington’s Disease Mice

Kreilaus, F., Spiro, A. S., Hannan, A. J., Garner, B., & Jenner, A. M. (2016) · Journal of Huntington s Disease · doi:10.3233/jhd-160204 · Cited by 38 · see citing works

Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer’s Disease

Beggiato, S., Tomasini, M. C., Cassano, T., & Ferraro, L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020428 · Cited by 37 · see citing works

Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen

Yang, G., Li, S., Li, Y., Yang, Y., & Pan, M. (2017) · Food & Function · doi:10.1039/c7fo01311f · Cited by 37 · see citing works

Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases

Cha, H. K., Chung, S., Lim, H. Y., Jung, J., & Son, G. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00496 · Cited by 36 · see citing works

Age and Gender Differences for the Behavioral Phenotypes of 3xTg Alzheimer's Disease mice.

Pairojana, T., Phasuk, S., Suresh, P., Huang, S.-P., Pakaprot, N., Chompoopong, S., Hsieh, T.-C., & Liu, I. Y. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147437 · Cited by 33 · see citing works

Simultaneous Separation and Purification of Five Polymethoxylated Flavones from “Dahongpao” Tangerine (Citrus tangerina Tanaka) Using Macroporous Adsorptive Resins Combined with Prep-HPLC

Li, Z., Zhao, Z., & Zhou, Z. (2018) · Molecules · doi:10.3390/molecules23102660 · Cited by 35 · see citing works

Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease

Shi, S.-C., Wang, H., Wang, J., Wang, Y., Xue, X.-B., Hou, Z., Yao, G., Huang, X., Zhao, H., Liu, Q., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103917 · Cited by 35 · see citing works

Citrus species: Modern functional food and nutraceutical-based product ingredient

Leporini, M., Tundis, R., Sicari, V., & Loizzo, M. R. (2021) · Italian Journal of Food Science · doi:10.15586/ijfs.v33i2.2009 · Cited by 35 · see citing works

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Szulc, A., Wiśniewska, K., Żabińska, M., Gaffke, L., Szota, M., Olendzka, Z., Węgrzyn, G., & Pierzynowska, K. (2024) · Foods · doi:10.3390/foods13121931 · Cited by 36 · see citing works

Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease.

Izadpanah, M., Dargahi, L., Ai, J., Taei, A. A., Barough, S. E., Mowla, S. J., Tavoosidana, G., & Farahmandfar, M. (2020) · PubMed Central · doi:10.22037/ijpr.2020.112062.13508 · Cited by 34 · see citing works

Nobiletin enhances the survival of random pattern skin flaps: Involvement of enhancing angiogenesis and inhibiting oxidative stress

Jiang, R., Chen, L., Jiang, C. Q., Huang, Z., Gao, W., & Lin, D. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106010 · Cited by 32 · see citing works

A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism

Matsuzaki, K., Nakajima, A., Guo, Y., & Ohizumi, Y. (2022) · Nutrients · doi:10.3390/nu14091847 · Cited by 32 · see citing works

Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation

Chai, W., Zhang, J., Xiang, Z.-B., Zhang, H., Mei, Z., Nie, H., Xu, R., & Zhang, P. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00932-7 · Cited by 31 · see citing works

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang, Y., Xiong, J., Wu, Y., & Ding, W. (2023) · European journal of medical research · doi:10.1186/s40001-023-01450-7 · Cited by 29 · see citing works

Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector

Shin, E., Chung, Y. H., Sharma, N., Nguyen, B. T., Lee, S. H., Kang, S. W., Nah, S.-Y., Wie, M., Nabeshima, T., Jeong, J. H., et al. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03147-3 · Cited by 29 · see citing works

Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatments of Alzheimer’s disease: A comprehensive review

Jin, X., Guo, J., Wang, L., Zhong, X., Yao, W., Gao, H., & Liu, M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113401 · Cited by 29 · see citing works

Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Synthesis, characterization and evaluation for targeted drug delivery

Bhattacherjee, A., Dhara, K., & Chakraborti, A. S. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.042 · Cited by 26 · see citing works

Inhibitory effects of Inula britannica extract fermented by Lactobacillus plantarum KCCM 11613P on coagulase activity and growth of Staphylococcus aureus including methicillin‐resistant strains

Bae, W., Kim, H., Kim, K., & Paik, H. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12785 · Cited by 25 · see citing works

Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms

Mushtaq, Z., Aslam, M., Imran, M., Abdelgawad, M. A., Saeed, F., Khursheed, T., Umar, M., Abdulmonem, W. A., El-Ghorab, A. H., Alsagaby, S. A., et al. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2189568 · Cited by 24 · see citing works

Nobiletin Alleviates Astrocyte Activation and Oxidative Stress Induced by Hypoxia In Vitro

Wang, D., Gao, F., Hu, F., & Wu, J. (2022) · Molecules · doi:10.3390/molecules27061962 · Cited by 23 · see citing works

Nobiletin Ameliorates Cellular Damage and Stress Response and Restores Neuronal Identity Altered by Sodium Arsenate Exposure in Human iPSCs-Derived hNPCs

Jahan, S., Ansari, U. A., Siddiqui, A. J., Iqbal, D., Khan, J., Banawas, S., Alshehri, B., Alshahrani, M. M., Alsagaby, S. A., Redhu, N. S., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15050593 · Cited by 22 · see citing works

Chitosan – An alternative drug delivery approach for neurodegenerative diseases

Iyer, M., Elangovan, A., Ramya, S., Babu, H. W. S., Saranya, T., Krishnan, J., Yadav, M., Gopalakrishnan, A. V., Narayanasamy, A., & Vellingiri, B. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100460 · Cited by 22 · see citing works

Role of Natural Plant Products Against Alzheimer’s Disease

Varshney, H., & Siddique, Y. H. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210420135437 · Cited by 22 · see citing works

Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging

Mileykovskaya, E., Yoo, S., Dowhan, W., & Chen, Z. (2020) · Biochemistry (Moscow) · doi:10.1134/s000629792012007x · Cited by 21 · see citing works

Dietary Methylglyoxal Exposure Induces Alzheimer’s Disease by Promoting Amyloid β Accumulation and Disrupting Autophagy in Caenorhabditis elegans

Wei, C., Li, S.-W., Wu, C., How, C. M., & Pan, M. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03411 · Cited by 19 · see citing works

Natural polyphenol: Their pathogenesis-targeting therapeutic potential in Alzheimer's disease

Niu, C., Dong, M., & Niu, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116359 · Cited by 19 · see citing works

A Scientometric Study to a Critical Review on Promising Anticancer and Neuroprotective Compounds: Citrus Flavonoids

Qiu, M., Wei, W., Zhang, J., Wang, H., Bai, Y., & Guo, D. (2023) · Antioxidants · doi:10.3390/antiox12030669 · Cited by 18 · see citing works

Resetting the Aging Clock: Implications for Managing Age-Related Diseases

Nobrega, A. K. D., Luz, K. V., & Lyons, L. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_9 · Cited by 18 · see citing works

Therapeutic potential of plant-derived flavonoids against inflammation

Mir, R. H., Mohi-ud-din, R., Mir, P. A., Maqbool, M., Banday, N., Farooq, S., Raza, S. N., & Chawla, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99988-5.00019-x · Cited by 17 · see citing works

An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling

Shin, E., Lee, S. H., Sharma, N., Nguyen, B. T., Chung, Y. H., Kang, S. W., Nah, S.-Y., Lee, Y. J., Nabeshima, T., Jeong, J. H., et al. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1854455 · Cited by 17 · see citing works

Evaluation of Amyloid Polypeptide Aggregation Inhibition and Disaggregation Activity of A-Type Procyanidins

Tanaka, T., Betkekar, V. V., Ohmori, K., Suzuki, K., & Shigemori, H. (2021) · Pharmaceuticals · doi:10.3390/ph14111118 · Cited by 16 · see citing works

Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K., Lu, W., Lin, C.-Y., Geraldine, P., Li, J.-Y., & Sheu, J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2822 · Cited by 15 · see citing works

Nobiletin inhibits viability of human renal carcinoma cells via the JAK2/STAT3 and PI3K/Akt pathway

Xu, Z., Wu, D., Fu, D., Tang, C., Ge, J., Zhang, Z., & Zhou, W. (2020) · Cellular and Molecular Biology · doi:10.14715/cmb/2020.66.5.33 · Cited by 15 · see citing works

Anthocyanin‐rich blackcurrant extract improves long‐term memory impairment and emotional abnormality in senescence‐accelerated mice

Shimada, M., Maeda, H., Nanashima, N., Yamada, K., & Nakajima, A. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14295 · Cited by 15 · see citing works

Kampo formulas alleviate aging-related emotional disturbances and neuroinflammation in male senescence-accelerated mouse prone 8 mice

Ito, N., Maruko, A., Oshima, K., Yoshida, M., Honma, K., Sugiyama, C., Nagai, T., Kobayashi, Y., Odaguchi, H., & Okada, N. (2022) · Aging · doi:10.18632/aging.203811 · Cited by 14 · see citing works

Nobiletin attenuates inflammation via modulating proinflammatory and antiinflammatory cytokine expressions in an autoimmune encephalomyelitis mouse model

Yarım, G. F., Yarım, M., Sözmen, M., Gökçeoğlu, A., Ertekin, A., Kabak, Y. B., & Karaca, E. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.105099 · Cited by 13 · see citing works

Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications

Vu, T.-D., Ito, N., Oshima, K., Maruko, A., Nishi, A., Mizoguchi, K., Odaguchi, H., Kobayashi, Y., & Okada, N. (2022) · Gene · doi:10.1016/j.gene.2022.146496 · Cited by 12 · see citing works

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

Nakamoto, A., Mitani, M., Urayama, K., Akari, M. A. K. I., Nakamoto, M., Shuto, E., Yoshitaka, N. I. I., & Sakai, T. (2019) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.65.278 · Cited by 12 · see citing works

Grape skin extract modulates neuronal stem cell proliferation and improves spatial learning in senescence-accelerated prone 8 mice

Sasaki, K., Geribaldi‐Doldán, N., Szele, F. G., & Isoda, H. (2021) · Aging · doi:10.18632/aging.203373 · Cited by 11 · see citing works

Flavones from Heavenly Blue as modulators of Alzheimer’s amyloid-beta peptide (Aβ) production

Awad, H. M., Abd-Alla, H. I., Ibrahim, M. A., El-Sawy, E. R., & Abdalla, M. M. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2100-x · Cited by 11 · see citing works

Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer’s disease model mouse line

Russo-Savage, L., Rao, V. K. S., Eipper, B. A., & Mains, R. E. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.07.006 · Cited by 11 · see citing works

Microwave Assisted Extraction of Flavonoids: A Comprehensive Overview

Routray, W., & Orsat, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.21108-6 · Cited by 10 · see citing works

Therapeutic Potential of Polyphenols in Cellular Reversal of Patho‐Mechanisms of Alzheimer's Disease Using In Vitro and In Vivo Models: A Comprehensive Review

Samal, M., Srivastava, V., Khan, M., Insaf, A., Penumallu, N. R., Alam, A., Parveen, B., Ansari, S. H., & Ahmad, S. (2024) · Phytotherapy Research · doi:10.1002/ptr.8344 · Cited by 8 · see citing works

Nobiletin Relaxes Isolated Mesenteric Arteries by Activating the Endothelial Ca2+-eNOS Pathway in Rats

Yang, W., Li, S., Liao, L., Zheng, X., Li, J., Zheng, Y., Zhang, X., & Zhu, D. (2016) · Journal of Vascular Research · doi:10.1159/000452415 · Cited by 8 · see citing works

Apple Pomace Extract Improves MK-801-Induced Memory Impairment in Mice

Watanabe, A., Shimada, M., Maeda, H., Narumi, T., Ichita, J., Itoku, K., & Nakajima, A. (2024) · Nutrients · doi:10.3390/nu16020194 · Cited by 8 · see citing works

Phytochemical Compounds Loaded to Nanocarriers as Potential Therapeutic Substances for Alzheimer’s Disease-Could They be Effective?

Polat, D. Ç., Karadağ, A. E., Köprülü, R. E. P., Karantas, I. D., Mutlu, G., Çağlar, E. Ş., Okur, M. E., Okur, N. Ü., & Siafaka, P. I. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220411104128 · Cited by 7 · see citing works

Modulation of the receptor for advanced glycation end products pathway by natural polyphenols: A therapeutic approach to neurodegenerative diseases

Wei, Y., Zhang, Y., Sun, J., Li, W., Zhao, X., Tian, N., Cao, Y., & Xie, J. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105511 · Cited by 7 · see citing works

Nobiletin improves emotional and novelty recognition memory but not spatial referential memory

Kang, J., Shin, J.-W., Kim, Y., Swanberg, K. M., Kim, Y., Bae, J. R., Kim, Y. K., Lee, J., Kim, S.-Y., Sohn, N., et al. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1047-4 · Cited by 7 · see citing works

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Onozuka, H., Nakajima, A., Matsuzaki, K., Shin, R., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., Sashida, Y., Mimaki, Y., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.140293 · Cited by 220 · see citing works

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Onozuka, H., Nakajima, A., Matsuzaki, K., Shin, R.-W., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., SASHIDA, Y., Mimaki, Y., et al. (2008)

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Ghasemi-Tarie, R., Kiasalari, Z., Fakour, M., Khorasani, M., Keshtkar, S., Baluchnejadmojarad, T., & Roghani, M. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00949-y · Cited by 42 · see citing works

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Nakajima, A., Ohizumi, Y., & Yamada, K. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.2.75 · Cited by 64 · see citing works

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Baek, H., Park, M., & Lee, H. (2026) · Biomedicines · doi:10.3390/biomedicines14030561 · Cited by 6 · see citing works