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Cited by 232

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

Xu, Peng-xin, Wang, Shao-wei, Yu, Xiao-lin, Su, Ya-jing, Wang, Teng, Zhou, Wei-wei, Zhang, He, Wang, Yu-jiong, Liu, Rui-tian·2014·Behavioural Brain Research
DOI 10.1016/j.bbr.2014.02.002
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Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles in the brain. Aβ aggregation is closely associated with neurotoxicity, oxidative stress, and neuronal inflammation. The soluble Aβ oligomers are believed to be the most neurotoxic form among all forms of Aβ aggregates. We have previously reported a polyphenol compound rutin that could inhibit Aβ aggregation and cytotoxicity, attenuate oxidative stress, and decrease the production of nitric oxide and proinflammatory cytokines in vitro. In the current study, we investigated the effect of rutin on APPswe/PS1dE9 transgenic mice. Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric Aβ level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1β and IL-6 levels in the brain. These results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing Aβ oligomer activities.

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Research works printed but not linked: 37

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Cited by

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Metadata

Authors
Xu, P.-X., Wang, S.-W., Yu, X.-L., Su, Y.-J., Wang, T., Zhou, W.-W., Zhang, H., Wang, Y.-J., & Liu, R.-T.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2014-05
Volume
264
Pages
173-180
ISSN
0166-4328
DOI
10.1016/j.bbr.2014.02.002
Cited by
232
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Natural Science Foundation of China (30971012, 81171014)
  • National Science and Technology Major Projects of New Drugs (2012ZX09103301-001, 2014ZX09102041-007)

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