Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus
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The mesocorticolimbic dopaminergic system includes the ventral tegmental area (VTA) and its projections to the amygdala (AMY), the hippocampus (HIP) and the medial prefrontal cortex (mPFC), among others. Object recognition (OR) long-term memory (LTM) processing requires dopaminergic activity but, although some of the brain regions mentioned above are necessary for OR LTM consolidation, their possible dopamine-mediated interplay remains to be analyzed. Using adult male Wistar rats, we found that posttraining microinjection of the dopamine D1/D5 receptor antagonist SCH23390 in mPFC or AMY, but not in HIP, impaired OR LTM. The dopamine D2 receptor agonist quinpirole had no effect on retention. VTA inactivation also hindered OR LTM, and even though this effect was unaffected by co-infusion of the dopamine D1/D5 receptor agonist SKF38393 in HIP, mPFC or AMY alone, it was reversed by simultaneous activation of D1/D5 receptors in the last two regions. Our results demonstrate that the mesocorticolimbic dopaminergic system is indeed essential for OR LTM consolidation and suggest that the role played by some of its components during this process is much more complex than previously thought.
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Infusions of SCH23390 into the PFC impaired long-term 24 hours NOP memory when administrated immediately, but not 6 hours, after the sample trial.
“Infusions of SCH23390 into the PFC also impaired long-term 24 hours NOP memory when administrated immediately, but not 6 hours, after the sample trial (Rossato et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2013
Post-sample PFC infusions of quinpirole did not affect NOP performance.
“However, a study shows that post-sample PFC infusions of quinpirole did not affect NOP performance (Rossato et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2013
Post-sample hippocampal infusions of SCH23390 had no effect on long-term NOP memory.
“post-sample hippocampal infusions of SCH23390 had no effect on long-term NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2013
Post-sample trial microinjections of the D1-R antagonist SCH23390 and D3-R agonist 7-OH-DPAT, but not the D2-R antagonist L-741.626, into the hippocampus impaired NOP when tested 1 hour later.
“Post-sample trial microinjections of the D1-R antagonist SCH23390 and D3-R agonist 7-OH-DPAT, but not D2-R antagonist L-741.626, into the hippocampus impaired NOP when tested 1 hour later”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2013
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- Authors
- Rossato, J. I., Radiske, A., Kohler, C. A., Gonzalez, C., Bevilaqua, L. R., Medina, J. H., & Cammarota, M.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Universidad de Buenos Aires (AR)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 106
- Pages
- 66-70
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2065427765
- Cited by
- 75
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 3
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- green
- repositorio.ufrn.br
- Licence
- other-oa
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Funders
- International Brain Research Organization
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Fundação de Apoio à Pesquisa do Rio Grande do Norte
- Agencia Nacional de Promoción Científica y Tecnológica
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- object recognition memory, long-term memory consolidation, dopamine D1/D5 receptors, ventral tegmental area, amygdala, medial prefrontal cortex, hippocampus, quinpirole, SCH 23390, SKF 38393
- MeSH terms
- Amygdala, Animals, Benzazepines, Hippocampus, Male, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Rats, Wistar, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Receptors, Dopamine D5, Rats
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