CoChat
Sign Up
Cited by 39Cellular transport and secretionProtein Kinase Regulation and GTPase SignalingCaveolin-1 and cellular processes

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1

Czubayko, Martin, Knauth, Peter, Schlüter, Thomas, Florian, Volker, Bohnensack, Ralf·2006·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2006.04.129
Open this paper in CoChat — free account

Abstract

The mammalian sorting nexin (SNX) proteins are involved in the endocytosis and the sorting machinery of transmembrane proteins. Additionally to the family defining phox homology (PX) domain, SNX17 is the only member with a truncated FERM (4.1, ezrin, radixin, and moesin) domain and a unique C-terminal region (together designated as FC unit). By gel filtration and lipid overlay assays we show that SNX17 is a non-self-assembling and a PtdIns(3)P high class affinity protein. A SNX17 affinity to any other phosphoinositides was not detected. By yeast two-hybrid- and GST-trapping assays we identified KRIT1 (krev1 interaction trapped 1) as a new specific interaction partner of the FC unit of SNX17. KRIT1 binds SNX17 by its N-terminal region like the known interaction partner ICAP1alpha (integrin cytoplasmic domain-associated protein-1). The interaction was also detected in HEK 293 cells transiently expressing GFP-tagged KRIT1 and Xpress-tagged SNX17. KRIT1 mutations cause cerebral cavernous malformation (CCM1). Our finding suggests a SNX17 involvement in the indicated KRIT1 function in cell adhesion processes by integrin signaling.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbrc.2006.04.129

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The SNX17 PX domain facilitates interaction between SNX17 and PI3P-enriched membranes, particularly early endosome membranes that are positive for EEA1.

    “Its PX domain facilitates the interaction between SNX17 and PI3P-enriched membranes, particularly with the early endosome membranes that are positive for EEA1 [27]–[29].”

    From Sorting nexin 17 regulates ApoER2 recycling and reelin signaling (2014) · cites this paper as [29]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 41

  1. Worby, 2002, Sorting out the cellular functions of sorting nexins, Nat. Rev. Mol. Cell Biol., 3, 919, 10.1038/nrm974 · DOI · Paper page
  2. Carlton, 2005, Sorting nexins—unifying trends and new perspectives, Traffic, 6, 75, 10.1111/j.1600-0854.2005.00260.x · DOI
  3. Teasdale, 2001, A large family of endosome-localized proteins related to sorting nexin 1, Biochem. J., 358, 7, 10.1042/bj3580007 · DOI
  4. Xu, 2001, The phox homology (PX) domain, a new player in phosphoinositide signalling, Biochem. J., 360, 513, 10.1042/bj3600513 · DOI
  5. Ponting, 1996, Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?, Protein Sci., 5, 2353, 10.1002/pro.5560051122 · DOI · Paper page
  6. Cozier, 2002, The Phox homology (PX) domain-dependent, 3-phosphoinositide mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation, J. Biol. Chem., 277, 48730, 10.1074/jbc.M206986200 · DOI · Paper page
  7. Lundmark, 2003, Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components, J. Biol. Chem., 278, 46772, 10.1074/jbc.M307334200 · DOI
  8. Florian, 2001, A new member of the sorting nexin family interacts with the C-terminus of P-selectin, Biochem. Biophys. Res. Commun., 281, 1045, 10.1006/bbrc.2001.4467 · DOI · Paper page
  9. Williams, 2004, Sorting nexin 17 accelerates internalisation yet retards degradation of P-selectin, Mol. Biol. Cell, 15, 3095, 10.1091/mbc.e04-02-0143 · DOI · Paper page
  10. Knauth, 2005, Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking, J. Mol. Biol., 347, 813, 10.1016/j.jmb.2005.02.004 · DOI · Paper page
  11. Serebriiskii, 1997, Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21–22, Oncogene, 15, 1043, 10.1038/sj.onc.1201268 · DOI
  12. Laberge-le Couteulx, 1999, Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas, Nat. Genet., 23, 189, 10.1038/13815 · DOI
  13. Guzeloglu-Kaysil, 2004, KRIT1/Cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex, Neurosurgery, 54, 943, 10.1227/01.NEU.0000114512.59624.A5 · DOI
  14. Zhang, 2001, Interaction between krit1 and icap1α infers perturbation of integrin β1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation, Hum. Mol. Genet., 10, 2953, 10.1093/hmg/10.25.2953 · DOI
  15. Zawistowski, 2002, KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis, Hum. Mol. Genet., 11, 389, 10.1093/hmg/11.4.389 · DOI
  16. Chang, 1997, ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin, J. Cell Biol., 138, 1149, 10.1083/jcb.138.5.1149 · DOI
  17. Gunel, 2002, KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein, Proc. Natl. Acad. Sci. USA, 99, 10677, 10.1073/pnas.122354499 · DOI
  18. Zawistowski, 2005, CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis, Hum. Mol. Genet., 14, 2521, 10.1093/hmg/ddi256 · DOI
  19. Fournier, 2005, Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation, Mol. Biol. Cell, 16, 1859, 10.1091/mbc.e04-08-0744 · DOI
  20. Uhlik, 2003, Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock, Nat. Cell Biol., 5, 1104, 10.1038/ncb1071 · DOI
  21. Carlton, 2004, Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides, Curr. Biol., 14, 1791, 10.1016/j.cub.2004.09.077 · DOI · Paper page
  22. Kurten, 2001, Self-assembly and binding of a sorting nexin to sorting endosomes, J. Cell Sci., 114, 1743, 10.1242/jcs.114.9.1743 · DOI · Paper page
  23. Nakamura, 2001, Association of mouse sorting nexin 1 with early endosomes, J. Biochem., 130, 765, 10.1093/oxfordjournals.jbchem.a003047 · DOI
  24. Parks, 2001, Sorting nexin 6, a novel SNX, interacts with the TGF-beta family of receptor serinethreonine kinases, J. Biol. Chem., 276, 19332, 10.1074/jbc.M100606200 · DOI · Paper page
  25. Hanson, 2003, Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments, J. Biol. Chem., 278, 34617, 10.1074/jbc.M300143200 · DOI
  26. Zhong, 2002, Endosomal localization and function of sorting nexin 1, Proc. Natl. Acad. Sci. USA, 99, 6767, 10.1073/pnas.092142699 · DOI
  27. Riley, 1996, Multimer formation as a consequence of separate homodimerization domains: the human c-Jun leucine zipper is a transplantable dimerization module, Prot. Eng., 9, 223, 10.1093/protein/9.2.223 · DOI
  28. Dowler, 2000, Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities, Biochem J., 351, 19, 10.1042/bj3510019 · DOI
  29. Nomura, 1994, Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041–KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1, DNA Res., 1, 251, 10.1093/dnares/1.5.251 · DOI
  30. Kurten, 1996, Enhanced degradation of EGF receptors by a sorting nexin, SNX1, Science, 272, 1001, 10.1126/science.272.5264.1008 · DOI · Paper page
  31. Horazdovsky, 1997, A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor, Mol. Biol. Cell., 8, 1529, 10.1091/mbc.8.8.1529 · DOI
  32. Seaman, 1998, A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast, J. Cell. Biol., 142, 665, 10.1083/jcb.142.3.665 · DOI · Paper page
  33. Griffin, 2005, Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2, Proc. Natl. Acad. Sci. USA, 102, 15173, 10.1073/pnas.0409558102 · DOI
  34. Bravo, 2001, The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate, Mol. Cell., 8, 829, 10.1016/S1097-2765(01)00372-0 · DOI
  35. Cheever, 2001, Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes, Nat. Cell Biol., 3, 613, 10.1038/35083000 · DOI · Paper page
  36. Lemmon, 2003, Phosphoinositide recognition domains, Traffic, 4, 201, 10.1034/j.1600-0854.2004.00071.x · DOI
  37. Yu, 2001, All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate, J. Biol. Chem., 276, 44179, 10.1074/jbc.M108811200 · DOI
  38. Burda, 2002, Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase, J. Cell Sci., 115, 3889, 10.1242/jcs.00090 · DOI
  39. Calderwood, 2002, The phosphotyrosine binding-like domain of talin activates integrins, J. Biol. Chem., 277, 21749, 10.1074/jbc.M111996200 · DOI
  40. Campbell, 2004, The talin-tail interaction places integrin activation on FERM ground, Trends Biochem. Sci., 29, 429, 10.1016/j.tibs.2004.06.005 · DOI
  41. Gillooly, 2003, Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes, Histochem. Cell Biol., 120, 445, 10.1007/s00418-003-0591-7 · DOI

Cited by

Sorted by citations

Metadata

Authors
Czubayko, M., Knauth, P., Schlüter, T., Florian, V., & Bohnensack, R.
Affiliations
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • Universidad de Guadalajara (MX)
Corresponding author
Bohnensack, Ralf
ORCID
Knauth, Peter
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2006-07
Volume
345
Issue
3
Pages
1264-1272
ISSN
0006-291X (ISSN-L)
DOI
10.1016/j.bbrc.2006.04.129
OpenAlex
W2000183806
Cited by
39
References
4
Citations by year
2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 1
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Health and Human Services
  • National University of Singapore
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
SNX17, KRIT1, cerebral cavernous malformations, PtdIns(3)P, FERM domain, protein-protein interaction, phosphoinositide binding, integrin signaling, cell adhesion, endocytosis
MeSH terms
KRIT1 Protein, Carrier Proteins, Cell Communication, Chromatography, Gel, Glutathione, Humans, Kinetics, Microtubule-Associated Proteins, Phosphatidylinositols, Proto-Oncogene Proteins, Integrins, Protein Structure, Tertiary, Phosphatidylinositol 3-Kinases, Hemangioma, Cavernous, Central Nervous System, Two-Hybrid System Techniques, Vesicular Transport Proteins, Endothelial Cells, Sorting Nexins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review