Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078 · see citing works

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works

Intracellular amyloid-β in Alzheimer's disease

LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works

Aβ Oligomers – a decade of discovery

Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

Pike, C., Burdick, D., Walencewicz, A., Glabe, C., & Cotman, C. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01676.1993 · Cited by 1,417 · see citing works

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works

Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways

Bitan, G., Kirkitadze, M. D., Lomakin, A., Vollers, S. S., Benedek, G. B., & Teplow, D. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222681699 · Cited by 1,280 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

Misko, T. P., Schilling, R. J., Salvemini, D., Moore, W. M., & Currie, M. G. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1449 · Cited by 1,027 · see citing works

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 835 · see citing works

Astroglial networks: a step further in neuroglial and gliovascular interactions

Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2757 · Cited by 781 · see citing works

Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus

Puzzo, D., Privitera, L., Leznik, E., Fà, M., Staniszewski, A., Palmeri, A., & Arancio, O. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2692-08.2008 · Cited by 740 · see citing works

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

Hartmann, T., Bieger, S. C., Brühl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1016 · Cited by 706 · see citing works

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706 · see citing works

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · see citing works

Amyloid beta oligomers induce impairment of neuronal insulin receptors

Zhao, W., De Felice, F. G., Fernandez, S., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., & Klein, W. L. (2008) · The FASEB Journal · doi:10.1096/fj.06-7703com · Cited by 587 · see citing works

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569 · see citing works

Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works

Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer DiseasePreprint

Masters, C. L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006262 · Cited by 543 · see citing works

Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Kuperstein, I., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Debulpaep, M., Vandersteen, A., Segers‐Nolten, I., Van Der Werf, K., Subramaniam, V., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.211 · Cited by 532 · see citing works

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 525 · see citing works

BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-05.2005 · Cited by 521 · see citing works

Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease

Olabarria, M., Noristani, H. N., Verkhratsky, A., & Rodríguez, J. J. (2010) · Glia · doi:10.1002/glia.20967 · Cited by 499 · see citing works

Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease

Nagele, R. G., Węgiel, J., Venkataraman, V., Imaki, H., Wang, K.-C., & Wegiel, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.007 · Cited by 497 · see citing works

Astrocytes in Alzheimer's Disease

Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 453 · see citing works

Microglia and Inflammation in Alzheimers Disease

Mandrekar-Colucci, S., & Landreth, G. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012071 · Cited by 421 · see citing works

Dimerization of the Extracellular Calcium-sensing Receptor (CaR) on the Cell Surface of CaR-transfected HEK293 Cells

Bai, M., Trivedi, S., & Brown, E. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23605 · Cited by 406 · see citing works

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., & LaFerla, F. M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.014 · Cited by 384 · see citing works

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 370 · see citing works

Proteolytic Degradation of Amyloid -Protein

Saido, T., & Leissring, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006379 · Cited by 368 · see citing works

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., & Xu, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.742 · Cited by 366 · see citing works

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

Wang, G., Dinkins, M. B., He, Q., Zhu, G., Poirier, C., Campbell, A., Mayer‐Pröschel, M., & Bieberich, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340513 · Cited by 356 · see citing works

Glial cells in neuronal network function

Araque, A., & Navarrete, M. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0313 · Cited by 327 · see citing works

Neuroglia in neurodegeneration

Heneka, M. T., Rodriguez, J. J., & Verkhratsky, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 303 · see citing works

Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation

Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903200106 · Cited by 279 · see citing works

Costimulatory Effects of Interferon-γ and Interleukin-1β or Tumor Necrosis Factor α on the Synthesis of Aβ1-40 and Aβ1-42 by Human Astrocytes

Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., & Grubeck-Loebenstein, B. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0321 · Cited by 258 · see citing works

Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo

Reynolds, R., & Hardy, R. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970301)47:5 · Cited by 257 · see citing works

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

Magdesian, M. H., Carvalho, M., Mendes, F. A., Saraiva, L. M., Juliano, M. A., Juliano, L., Garcia-Abreu, J., & Ferreira, S. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707108200 · Cited by 251 · see citing works

In vivo conversion of racemized β‐amyloid ([ D ‐Ser26]Aβ1–40) to truncated and toxic fragments ([ D ‐Ser26]Aβ25–35/40) and fragment presence in the brains of Alzheimer's patients

Kubo, T., Nishimura, S., Kumagae, Y., & Kaneko, I. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10391 · Cited by 250 · see citing works

The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

Plant, L. D., Boyle, J. P., Smith, I. F., Peers, C., & Pearson, H. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05531.2003 · Cited by 248 · see citing works

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

Nath, S., Agholme, L., Kurudenkandy, F. R., Granseth, B., Marcusson, J., & Hallbeck, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0615-12.2012 · Cited by 244 · see citing works

Very long term studies of the seeding of β-amyloidosis in primates

Ridley, R. M., Baker, H. F., Windle, C. P., & Cummings, R. M. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0385-2 · Cited by 186 · see citing works

Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function

Bai, M., Trivedi, S., Kifor, O., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2834 · Cited by 184 · see citing works

Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model

Reilly, J. F., Games, D., Rydel, R. E., Freedman, S. B., Schenk, D., Young, W. G., Morrison, J. H., & Bloom, F. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0330745100 · Cited by 170 · see citing works

Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

Davey, A. E., Leach, K., Valant, C., Conigrave, A. D., Sexton, P. M., & Christopoulos, A. (2011) · Endocrinology · doi:10.1210/en.2011-1426 · Cited by 168 · see citing works

Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35

Kaminsky, Y. G., Marlatt, M. W., Smith, M. A., & Kosenko, E. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.005 · Cited by 165 · see citing works

Transplanted astrocytes internalize deposited β‐amyloid peptides in a transgenic mouse model of Alzheimer's disease

Pihlaja, R., Koıstınaho, J., Malm, T., Sikkilä, H., Vainio, S. J., & Koistinaho, M. (2007) · Glia · doi:10.1002/glia.20599 · Cited by 162 · see citing works

Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme

Roßner, S., Lange‐Dohna, C., Zeitschel, U., & Perez-Polo, J. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02857.x · Cited by 161 · see citing works

Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity

Counts, S., & Mufson, E. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06622.x · Cited by 154 · see citing works

Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

Perini, G., Bianca, V. D., Politi, V., Valle, G. D., Prà, I. D., Rossi, F., & Armato, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011797 · Cited by 152 · see citing works

Amyloid Precursor Protein and Notch Intracellular Domains are Generated after Transport of their Precursors to the Cell Surface

Kaether, C., Schmitt, S., Willem, M., & Haass, C. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00396.x · Cited by 148 · see citing works

Delineating a Ca2+ Binding Pocket within the Venus Flytrap Module of the Human Calcium-sensing Receptor

Silve, C., Pétrel, C., Leroy, C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506263200 · Cited by 143 · see citing works

LRP in Amyloid‐β Production and Metabolism

Bu, G., Cam, J. A., & Zerbinatti, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.005 · Cited by 133 · see citing works

Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly

Pidasheva, S., Grant, M. P., Canaff, L., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl145 · Cited by 132 · see citing works

Human Cortical Neuronal Cell Line: Establishment From a Patient with Unilateral Megalencephaly

Ronnett, G. V., Hester, L. D., Nye, J. S., Connors, K., & Snyder, S. H. (1990) · Science · doi:10.1126/science.1692158 · Cited by 127 · see citing works

The Ca2+ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

Brorson, J. R., Bindokas, V. P., Iwama, T., Marcuccilli, C. J., Chisholm, J. C., & Miller, R. J. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260305 · Cited by 124 · see citing works

Calcium-sensing receptor in the brain

Yano, S., Brown, E. M., & Chattopadhyay, N. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.10.008 · Cited by 122 · see citing works

Sequence Determinants of Enhanced Amyloidogenicity of Alzheimer Aβ42 Peptide Relative to Aβ40

Kim, W., & Hecht, M. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505763200 · Cited by 122 · see citing works

Intracellular Accumulation of Insoluble, Newly Synthesized Aβn-42 in Amyloid Precursor Protein-transfected Cells That Have Been Treated with Aβ1–42

Yang, A. J., Chandswangbhuvana, D., Shu, T., Henschen, A., & Glabe, C. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20650 · Cited by 108 · see citing works

Agonists and Allosteric Modulators of the Calcium-Sensing Receptor and Their Therapeutic Applications

Saidak, Z., Brazier, M., Kamel, S., & Mentaverri, R. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058784 · Cited by 105 · see citing works

The role of the calcium-sensing receptor in human disease

Ward, B. K., Magno, A. L., Walsh, J. P., & Ratajczak, T. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.034 · Cited by 104 · see citing works

Role of Formyl Peptide Receptor–Like 1 (FPRL1/FPR2) in Mononuclear Phagocyte Responses in Alzheimer Disease

Iribarren, P., Zhou, Y., Hu, J., Le, Y., & Wang, J. M. (2005) · Immunologic Research · doi:10.1385/ir:31:3:165 · Cited by 104 · see citing works

The search for calcium receptor antagonists (calcilytics)

Nemeth, E. F. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0290015 · Cited by 102 · see citing works

Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR)

Chakravarti, B., Chattopadhyay, N., & Brown, E. M. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_5 · Cited by 101 · see citing works

The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes.

Mulder, S., Veerhuis, R., Blankenstein, M., & Nielsen, H. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.001 · Cited by 95 · see citing works

Aβ40 promotes neuronal cell fate in neural progenitor cells

Chen, Y., & Dong, C. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.94 · Cited by 94 · see citing works

Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease

Stockley, J., & O'Neill, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8271-3 · Cited by 87 · see citing works

Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice

Chakravarthy, B., Gaudet, C., Ménard, M., Atkinson, T. G., Brown, L., LaFerla, F. M., Armato, U., & Whitfield, J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1288 · Cited by 85 · see citing works

Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor

Leach, K., Wen, A., Davey, A. E., Sexton, P. M., Conigrave, A. D., & Christopoulos, A. (2012) · Endocrinology · doi:10.1210/en.2012-1449 · Cited by 83 · see citing works

Processing of Amyloid Precursor Protein in Human Primary Neuron and Astrocyte Cultures

LeBlanc, A. C., Papadopoulos, M., Bélair, C., Chu, W. N., Crosato, M., Powell, J., & Goodyer, C. G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68031183.x · Cited by 80 · see citing works

Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers

Nygaard, H. B., & Strittmatter, S. M. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.223 · Cited by 72 · see citing works

β-Amyloid Racemized at the Ser26Residue in the Brains of Patients with Alzheimer Disease: Implications in the Pathogenesis of Alzheimer Disease

Kubo, T., Kumagae, Y., Miller, C. A., & Kaneko, I. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.3.248 · Cited by 71 · see citing works

Amyloid-β Peptide Is a Substrate of the Human 20S Proteasome

Zhao, X., & Yang, J. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100067e · Cited by 68 · see citing works

The Biphasic Role of Microglia in Alzheimer's Disease

Mizuno, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/737846 · Cited by 67 · see citing works

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

Fukumoto, H., Tomita, T., Matsunaga, H., Ishibashi, Y., Saido, T. C., & Iwatsubo, T. (1999) · Neuroreport · doi:10.1097/00001756-199909290-00017 · Cited by 61 · see citing works

Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease

Jürgensen, S., & Ferreira, S. T. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9237-0 · Cited by 57 · see citing works

Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes

Rajendran, L., Knobloch, M., Geiger, K. D., Dienel, S., Nitsch, R. M., Simons, K., & Konietzko, U. (2007) · Neurodegenerative Diseases · doi:10.1159/000101841 · Cited by 49 · see citing works

Roles of Ca²⁺ and the Ca²⁺‐sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)‐2 and its BH₄ (tetrahydrobiopterin)‐dependent activation in cytokine‐stimulated adult human astrocytes

Dal Pra, I., Chiarini, A., Nemeth, E. F., Armato, U., & Whitfield, J. F. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20511 · Cited by 47 · see citing works

Correlation among Secondary Structure, Amyloid Precursor Protein Accumulation, and Neurotoxicity of Amyloid β(25–35) Peptide as Analyzed by Single Alanine Substitution

Sato, K., Wakamiya, A., Maeda, T., et al. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124994 · Cited by 44 · see citing works

The Interaction of Amyloid β and the Receptor for Advanced Glycation Endproducts Induces Matrix Metalloproteinase-2 Expression in Brain Endothelial Cells

Du, H., Li, P., Wang, J., Qing, X., & Li, W. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9744-8 · Cited by 40 · see citing works

Calcilytics: Antagonists of the Calcium-Sensing Receptor for the Treatment of Osteoporosis

Widler, L. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.17 · Cited by 38 · see citing works

Amyloid-β-Induced Amyloid-β Secretion: A Possible Feed-Forward Mechanism in Alzheimer's Disease

Marsden, I. T., Minamide, L. S., & Bamburg, J. R. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101899 · Cited by 35 · see citing works

Amyloid-β25–35, an Amyloid-β1–42 Surrogate, and Proinflammatory Cytokines Stimulate VEGF-A Secretion by Cultured, Early Passage, Normoxic Adult Human Cerebral Astrocytes

Chiarini, A., Whitfield, J., Bonafini, C., Chakravarthy, B., Armato, U., & Prà, I. D. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100471 · Cited by 35 · see citing works

The Interaction of Amyloid b and the Receptor for Advanced Glycation Endproducts Induces Matrix Metalloproteinase-2 Expression in Brain Endothelial Cells

DuPengtao, H., Wang, L., & Li, X. Q. (2012) · Cited by 34 · see citing works

The Amyloid-β42 Proxy, Amyloid-β25-35, Induces Normal Human Cerebral Astrocytes to Produce Amyloid-β42

Prà, I. D., Whitfileld, J. F., Pacchiana, R., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101626 · Cited by 29 · see citing works

Human cortical neuronal (HCN) cell lines: a model for amyloid β neurotoxicity

Zhang, Z., Drzewiecki, G. J., Hom, J. T., May, P. C., & Hyslop, P. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90892-3 · Cited by 27 · see citing works

Growth stimulation and apoptosis induced in cultures of neonatal rat liver cells by repeated exposures to epidermal growth factor/urogastrone with or without associated pancreatic hormones

Armato, U., Romano, F., Andreis, P. G., et al. (1986) · Cell and Tissue Research · doi:10.1007/bf00218546 · Cited by 27 · see citing works

γ -Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β -Protein Production

Takami, M., & Funamoto, S. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/591392 · Cited by 27 · see citing works

Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice

Kummer, M. P., Hülsmann, C., Hermes, M., Axt, D., & Heneka, M. T. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9339-7 · Cited by 26 · see citing works

The calcium-sensing receptor: A novel Alzheimer's disease crucial target?

Armato, U., Bonafini, C., Chakravarthy, B., Pacchiana, R., Chiarini, A., Whitfield, J. F., & Prà, I. D. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.031 · Cited by 25 · see citing works

Soluble amyloid β-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes

Chiarini, A., Prà, I. D., Menapace, L., Pacchiana, R., Whitfield, J., & Armato, U. (2005) · International Journal of Molecular Medicine · doi:10.3892/ijmm.16.5.801 · Cited by 24 · see citing works

Dementia: new criteria but no new treatments

Sperling, R. A., & Johnson, K. A. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70272-1 · Cited by 22 · see citing works

Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine‐activated conditions

Chiarini, A., Armato, U., Pacchiana, R., & Prà, I. D. (2009) · PROTEOMICS · doi:10.1002/pmic.200800561 · Cited by 20 · see citing works

Regulation of Stability and Trafficking of Calcium-Sensing Receptors by Pharmacologic Chaperones

Huang, Y. S., Cavanaugh, A. H., & Breitwieser, G. E. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00007-5 · Cited by 18 · see citing works

BH4 (tetrahydrobiopterin)‐dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)‐2 in proinflammatory cytokine‐stimulated, cultured normal human astrocytes is mediated by MEK–ERK kinases

Chiarini, A., Prà, I. D., Gottardo, R., Bortolotti, F., Whitfield, J. F., & Armato, U. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20334 · Cited by 16 · see citing works

Purification of 20S Proteasomes

Beyette, J. R., Hubbell, T., & Monaco, J. J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-062-4:1 · Cited by 14 · see citing works

Soluble amyloid beta-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes

Chiarini, A., Prà, I. D., Menapace, L., et al. (2005) · NPARC · Cited by 14 · see citing works

The biology of Alzheimer's disease: 1

Delieu, J., & Keady, J. D. (1996) · British Journal of Nursing · doi:10.12968/bjon.1996.5.3.162 · Cited by 9 · see citing works

Solution NMR Studies of Aβ Monomer Dynamics

Wang, C. (2011) · Protein and Peptide Letters · doi:10.2174/092986611794653969 · Cited by 8 · see citing works

MEK inhibitors suppress β‐amyloid production by altering the level of a β‐C‐terminal fragment of amyloid precursor protein in neuronal cells

Araki, W., Kametani, F., Oda, A., et al. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.038 · Cited by 7 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases

Hannan, F. M., Kallay, E., Chang, W., Brandi, M. L., & Thakker, R. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0115-0 · Cited by 394 · see citing works

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

Chakroborty, S., & Stutzmann, G. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.012 · Cited by 91 · see citing works

Astroglial Calcium Signalling in Alzheimer's Disease

Verkhratsky, A., Rodríguez-Arellano, J. J., Parpura, V., & Zorec, R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.088 · Cited by 55 · see citing works

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

Chiarini, A., Armato, U., Liu, D., & Dal Prà, I. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00134 · Cited by 51 · see citing works

TFP inhibits the expression of the endogenous platelet lectin and secretion of α-granules

Gartner, T. K., & Walz, D. A. (1983) · Thrombosis Research · doi:10.1016/0049-3848(83)90126-3 · Cited by 9 · see citing works

The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs

Meel, J. C. A. V., Diederen, W., Haigh, R. M., et al. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90065-p · Cited by 8 · see citing works

Cimetidine's effect on dermal H1‐receptor antagonist tolerance.

Fairris, G. M., & Fairris, N. (1985) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1985.tb02643.x

Peptide cholesystokinin receptor antagonist increases food intake in rats

Brenner, L., & Ritter, R. C. (1995) · Appetite · doi:10.1016/s0195-6663(95)80001-8 · Cited by 30 · see citing works

Research advances in PAF and its receptor antagonist

Yan-jiang, Q. (2011) · Zhonghua zhongyiyao zazhi