Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins
Abstract
A common feature of Alzheimer's disease (AD) pathology is the abundance of reactive astrocytes and activated microglia in close proximity to neuritic plaques containing amyloid-beta protein (Abeta). The relationship between glial activation and neurodegeneration remains unclear, although several cytokines and inflammatory mediators produced by activated glia have the potential to initiate or exacerbate the progression of neuropathology. Assuming that glial activation plays a central role in the development and progression of AD, a prominent feature is to understand which stimuli drive this activation in senile plaques and to define their effects in vitro. There is a growing body of evidence to suggest that deposition of Abeta and expression of its associated molecules represent important trigger factors in glial activation leading to an inflammatory reaction in the brain. Thus, unraveling the mechanisms by which these proteins exert their effect on glial cells may provide significant insight into the pathophysiology of AD, and may lead to the identification of new strategies for AD treatment.
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Activated microglia may be involved in generation of Aβ plaque by increasing secretion of Aβ fragments; inducing IFITM3; or releasing iron which enhances aggregation of soluble β-amyloid.
“Activated microglia may be involved in the generation of Aβ plaque by increasing the secretion of Aβ fragments; inducing the expression of interferon-induced transmembrane protein 3 (IFITM3), a γ-secretase modulatory protein; or releasing agents such as iron, which enhances the aggregation of soluble β-amyloid.37–39”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [37]
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- Authors
- Meda, L.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Meda, L
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 22
- Issue
- 6
- Pages
- 885-893
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2055180596
- Cited by
- 222
- References
- 10
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 9 · 2013: 8 · 2012: 11
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, glial activation, amyloid-beta, reactive astrocytes, microglia, neuroinflammation, amyloid plaques, cytokines, neurodegeneration, inflammatory mediators
- MeSH terms
- Alzheimer Disease, Humans, Macrophage Activation, Neuroglia, Amyloid beta-Peptides
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