Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure
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Epidemiological evidences have correlated airbone particulate matter (PM) to adverse health effects, mainly linking to pulmonary and cardiovascular disease. Nevertheless, only recently, some studies reported detrimental effects of PM on other organs such as skin. In a recent work, we have reported increased oxidative and inflammatory responses in Reconstituted Human Epidermis (RHE) exposed to ambient particles (CAPs) and we also demonstrated the ability of CAPs to penetrate the skin tissue. The present study was aimed to better understand the cellular mechanisms beyond the oxidative changes induced by CAPs (5-10-25μg/mL) in human immortalized keratinocytes (HaCaT). After 24h of treatment, CAPs were able to enter the cells leading to a decrease in viability, increased levels of 4-hydroxinonenal products (4-HNE) and IL-1α release. Overall these data, suggest lipid and protein oxidative damage, as well as an increase of inflammatory response after being challenged with CAPs. In addition, 3h after CAPs exposure we found a significant increase in NF-kB and Nrf2 translocation into the nucleus. In contrast, no differences in gene expression and enzymatic activity of Nrf2 target genes were detected. This last finding could be explained by the ability of CAPs to possibly alter the binding of Nrf2 to the ARE DNA sequence.
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Oxidative stress responses were observed in HaCaT cells exposed to concentrated air particles and in primary human keratinocytes exposed to cigarette smoke condensate or diesel particulate extract.
“Oxidative stress responses were also observed in HaCaT cells exposed to concentrated air particles47 and in primary human keratinocytes exposed to cigarette smoke condensate48 or diesel particulate extract.49”
From The impact of airborne pollution on skin (2019) · cites this paper as [47]
Cites
Human health effects of air pollution
Kampa, M., & Castanas, E. (2008) · Environmental Pollution · doi:10.1016/j.envpol.2007.06.012 · Cited by 4,496 · see citing works
Ros and ros-mediated cellular signaling
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980 · see citing works
Air Pollution-Related Illness: Effects of Particles
Nel, A. E. (2005) · Science · doi:10.1126/science.1108752 · Cited by 1,551 · see citing works
Assay of glutathione reductase in crude tissue homogenates using 5,5′-dithiobis(2-nitrobenzoic acid)
Smith, I. K., Vierheller, T. L., & Thorne, C. A. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90564-7 · Cited by 1,342 · see citing works
Li, N., Xia, T., & Nel, A. E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.028 · Cited by 933 · see citing works
The Keap1–Nrf2–ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
Lu, M., Ji, J., Jiang, Z., & You, Q. (2016) · Medicinal Research Reviews · doi:10.1002/med.21396 · Cited by 807 · see citing works
Oxidative stress and air pollution exposure
Lodovici, M., & Bigagli, E. (2011) · Journal of Toxicology · doi:10.1155/2011/487074 · Cited by 720 · see citing works
Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697 · see citing works
Airborne Particle Exposure and Extrinsic Skin Aging
Vierkötter, A., Schikowski, T., Ranft, U., Sugiri, D., Matsui, M., Krämer, U., & Krutmann, J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.204 · Cited by 473 · see citing works
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Poli, G., Schaur, R. J., Siems, W. G., & Leonarduzzi, G. (2007) · Medicinal Research Reviews · doi:10.1002/med.20117 · Cited by 434 · see citing works
Motohashi, H., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305902101 · Cited by 363 · see citing works
Kampfrath, T., Maiseyeu, A., Ying, Z., Shah, Z., Deiuliis, J. A., Xu, X., Kherada, N. I., Brook, R. D., Reddy, K. M., Padture, N. P., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.237560 · Cited by 355 · see citing works
Hassanvand, M. S., Naddafi, K., Faridi, S., Nabizadeh, R., Sowlat, M. H., Momeniha, F., Gholampour, A., Arhami, M., Kashani, H., Zare, A., et al. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.05.001 · Cited by 257 · see citing works
Cutaneous responses to environmental stressors
Valacchi, G., Sticozzi, C., Pecorelli, A., Cervellati, F., Cervellati, C., & Maioli, E. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06724.x · Cited by 243 · see citing works
Self-citationChen, Z.-H., Saito, Y., Yoshida, Y., Sekine, A., Noguchi, N., & Niki, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508556200 · Cited by 197 · see citing works
Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure
Magnani, N., Mureșan, X. M., Belmonte, G., Cervellati, F., Sticozzi, C., Pecorelli, A., Miracco, C., Marchini, T., Evelson, P., & Valacchi, G. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv230 · Cited by 189 · see citing works
Self-citationLee, C.-W., Lin, Z.-C., Hu, S. C.-S., Chiang, Y.-C., Hsu, L.-F., Lin, Y.-C., Lee, I.-T., Tsai, M.-H., & Fang, J.-Y. (2016) · Scientific Reports · doi:10.1038/srep27995 · Cited by 188 · see citing works
Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2
Pi, J., Diwan, B. A., Sun, Y., Liu, J., Qu, W., He, Y., Stýblo, M., & Waalkes, M. P. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.020 · Cited by 181 · see citing works
The role of transcription factor Nrf2 in skin cells metabolism
Gęgotek, A., & Skrzydlewska, E. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1554-2 · Cited by 180 · see citing works
Tsuji, G., Takahara, M., Uchi, H., Matsuda, T., Chiba, T., Takeuchi, S., Yasukawa, F., Moroi, Y., & Furue, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.194 · Cited by 169 · see citing works
The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives
Kannan, M. B., Solovieva, V., & Blank, V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.06.012 · Cited by 161 · see citing works
Gerde, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.5.741 · Cited by 159 · see citing works
ANALYSIS OF AIR POLLUTION PARTICULATE-MEDIATED OXIDANT STRESS IN ALVEOLAR MACROPHAGES
Imrich, C.-A. W. G. A. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158683 · Cited by 141 · see citing works
Exposure to Concentrated Ambient Particles (CAPs): A Review
Ghio, A. J., & Huang, Y.-C. T. (2004) · Inhalation Toxicology · doi:10.1080/08958370490258390 · Cited by 130 · see citing works
Keller, U. A. D., Huber, M., Beyer, T. A., Kümin, A., Siemes, C., Braun, S., Bugnon, P., Mitropoulos, V., Johnson, D. A., Johnson, J. A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3773-3784.2006 · Cited by 122 · see citing works
Drakaki, E., Dessinioti, C., & Antoniou, C. V. (2014) · Frontiers in Environmental Science · doi:10.3389/fenvs.2014.00011 · Cited by 108 · see citing works
Sticozzi, C., Belmonte, G., Pecorelli, A., Arezzini, B., Gardi, C., Maioli, E., Miracco, C., Toscano, M., Forman, H. J., & Valacchi, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033592 · Cited by 107 · see citing works
Self-citationKimura, M., Yamamoto, T., Zhang, J., Itoh, K., Kyo, M., Kamiya, T., Aburatani, H., Katsuoka, F., Kurokawa, H., Tanaka, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706863200 · Cited by 102 · see citing works
Turnock, S. T., Butt, E., Richardson, T. B., Mann, G. W., Reddington, C. L. S., Forster, P. M. D. F., Haywood, J., Crippa, M., Janssens‐Maenhout, G., Johnson, C. E., et al. (2016) · Environmental Research Letters · doi:10.1088/1748-9326/11/2/024010 · Cited by 100 · see citing works
Hypoxia induces cell damage via oxidative stress in retinal epithelial cells
Cervellati, F., Cervellati, C., Romani, A., Cremonini, E., Sticozzi, C., Belmonte, G., Pessina, F., & Valacchi, G. (2013) · Free Radical Research · doi:10.3109/10715762.2013.867484 · Cited by 95 · see citing works
Self-citationPM10 impairs the antioxidant defense system and exacerbates oxidative stress driven cell death
Chirino, Y. I., Sánchez-Pérez, Y., Osornio-Vargas, Á. R., Morales‐Bárcenas, R., Gutiérrez‐Ruíz, M. C., Segura-García, Y., Rosas, I., Pedraza‐Chaverrí, J., & García-Cuellar, C. M. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.01.009 · Cited by 93 · see citing works
Valacchi, G., Sticozzi, C., Belmonte, G., Cervellati, F., Demaude, J., Chen, N., Krol, Y., & Oresajo, C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131097 · Cited by 90 · see citing works
Self-citationTrafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies
Theodore, M., McIntosh, D., Walters, T. S., Flores, A., Goodwin, J. S., & Arinze, I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437392 · Cited by 80 · see citing works
Environment‐induced lentigines: formation of solar lentigines beyond ultraviolet radiation
Nakamura, M., Morita, A., Seité, S., Haarmann‐Stemmann, T., Grether‐Beck, S., & Krutmann, J. (2015) · Experimental Dermatology · doi:10.1111/exd.12690 · Cited by 79 · see citing works
Marchini, T., Wolf, D., Michel, N. A., Mauler, M., Dufner, B., Hoppe, N., Beckert, J., Jäckel, M., Magnani, N., Duerschmied, D., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0562-5 · Cited by 79 · see citing works
Self-citationRothen‐Rutishauser, B., Mueller, L., Blank, F., Brandenberger, C., Mühlfeld, C., & Gehr, P. (2008) · ALTEX · doi:10.14573/altex.2008.3.191 · Cited by 75 · see citing works
Ishikado, A., Nishio, Y., Morino, K., Ugi, S., KONDO, H., Makino, T., Kashiwagi, A., & Maegawa, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.124 · Cited by 74 · see citing works
Cervellati, C., Sticozzi, C., Romani, A., Belmonte, G., Rasmo, D. D., Signorile, A., Cervellati, F., Milanese, C., Mastroberardino, P. G., Pecorelli, A., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.014 · Cited by 59 · see citing works
Self-citationEffects of atmospheric pollutants on the Nrf2 survival pathway
Rubio, V., Valverde, M., & Rojas, E. (2009) · Environmental Science and Pollution Research · doi:10.1007/s11356-009-0140-6 · Cited by 56 · see citing works
Rottlerin: a multifaced regulator of keratinocyte cell cycle
Valacchi, G., Pecorelli, A., Mencarelli, M., Carbotti, P., Fortino, V., Muscettola, M., & Maioli, E. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00816.x · Cited by 47 · see citing works
Self-citationLi, R., Zhao, L., Tong, J., Yan, Y., & Xu, C. B. (2016) · International Journal of Toxicology · doi:10.1177/1091581816682225 · Cited by 43 · see citing works
4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation
Valacchi, G., Pecorelli, A., Cervellati, C., & Hayek, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.045 · Cited by 37 · see citing works
Self-citationLi, Y., Kawada, T., & Azuma, A. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/323607 · Cited by 36 · see citing works
Percutaneous absorption of [7.10-14C]benzo[a]pyrene and [7,12-14C]dimethylbenz[a]anthracene in mice
Sanders, C. L., Skinner, C. S., & Gelman, R. A. (1984) · Environmental Research · doi:10.1016/0013-9351(84)90033-1 · Cited by 32 · see citing works
Shi, J., Deng, H., & Zhang, M. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6935 · Cited by 30 · see citing works
Marchini, T., D’Annunzio, V., Paz, M. L., Cáceres, L., Garcés, M., Pérez, V., Tasat, D. R., Vanasco, V., Magnani, N., Maglio, D. H. G., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00359.2015 · Cited by 29 · see citing works
Self-citationBrandenberger, C., Rothen‐Rutishauser, B., Blank, F., Gehr, P., & Mühlfeld, C. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-22 · Cited by 27 · see citing works
Arimoto, T., Toshikazu, Y., Takano, H., & Kohno, M. (1999) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.80.49 · Cited by 26 · see citing works
Role of transition metals present in air particulate matter on lung oxygen metabolism
Magnani, N., Marchini, T., Garcés, M., Mebert, A. M., Cáceres, L., Díaz, L. E., Desimone, M. F., & Evelson, P. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.10.009 · Cited by 26 · see citing works
Self-citationPiao, M. S., Choi, J.-Y. J., Lee, D.-H., Yun, S. J., Lee, J.-B., & Lee, S. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.02.003 · Cited by 25 · see citing works
Cervellati, F., Pavan, B., Lunghi, L., Manni, E., Fabbri, E., Mascoli, C., Biondi, C., Patella, A., & Vesce, F. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10077 · Cited by 16 · see citing works
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Araviiskaia, E., Berardesca, E., Bieber, T., Gontijo, G., Sanchez Viera, M., Marrot, L., Chuberre, B., & Dreno, B. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15583 · Cited by 214 · see citing works
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202 · see citing works
Self-citationCan Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?
Boo, Y. C. (2019) · Antioxidants · doi:10.3390/antiox8090379 · Cited by 121 · see citing works
Hernandez, D. F., Lugo‐Cervantes, E., Luna‐Vital, D. A., & Mojica, L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1805407 · Cited by 114 · see citing works
Algae as an Attractive Source for Cosmetics to Counter Environmental Stress
Aslam, A., Bahadar, A., Liaquat, R., Saleem, M., Waqas, A., & Zwawi, M. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144905 · Cited by 105 · see citing works
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94 · see citing works
Air pollution and skin diseases: A comprehensive evaluation of the associated mechanism.
Gu, X., Li, Z., & Su, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116429 · Cited by 91 · see citing works
Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage
Pecorelli, A., Woodby, B. L., Prieux, R., & Valacchi, G. (2019) · BioFactors · doi:10.1002/biof.1513 · Cited by 88 · see citing works
Self-citationOxidative contribution of air pollution to extrinsic skin ageing
Fussell, J. C., & Kelly, F. J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.038 · Cited by 85 · see citing works
Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage
Valacchi, G., Magnani, N., Woodby, B. L., Ferreira, S. M., & Evelson, P. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.8015 · Cited by 79 · see citing works
Self-citationNatural compounds protect the skin from airborne particulate matter by attenuating oxidative stress
Diao, P., He, H., Tang, J., Xiong, L., & Li, L. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111534 · Cited by 72 · see citing works
Ferrara, F., Woodby, B. L., Pecorelli, A., Schiavone, M. L., Pambianchi, E., Messano, N., Therrien, J., Choudhary, H., & Valacchi, G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101481 · Cited by 64 · see citing works
Self-citationCervellati, F., Benedusi, M., Manarini, F., Woodby, B. L., Russo, M., Valacchi, G., & Pietrogrande, M. C. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124746 · Cited by 56 · see citing works
Self-citationUltraviolet Light Protection: Is It Really Enough?
Farris, P. K., & Valacchi, G. (2022) · Antioxidants · doi:10.3390/antiox11081484 · Cited by 55 · see citing works
Self-citationNiacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
Zhen, A. X., Piao, M. J., Kang, K. A., Fernando, P. D. S. M., Kang, H. K., Koh, Y. S., Yi, J. M., & Hyun, J. W. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.061 · Cited by 52 · see citing works
Redox regulation of cutaneous inflammasome by ozone exposure
Ferrara, F., Pambianchi, E., Pecorelli, A., Woodby, B. L., Messano, N., Therrien, J., Lila, M. A., & Valacchi, G. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.031 · Cited by 51 · see citing works
Self-citationEffect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging
Hyun, Y. J., Piao, M. J., Kang, K. A., Zhen, A. X., Fernando, P. D. S. M., Kang, H. K., Ahn, Y. S., & Hyun, J. W. (2019) · Marine Drugs · doi:10.3390/md17010061 · Cited by 48 · see citing works
Ha, J. W., Song, H., Hong, S. S., & Boo, Y. C. (2019) · Antioxidants · doi:10.3390/antiox8060190 · Cited by 44 · see citing works
Bierman, J. C., Laughlin, T., Tamura, M., Hulette, B. C., Mack, C. E., Sherrill, J. D., Tan, C. Y. R., Morenc, M., Bellanger, S., & Oblong, J. E. (2020) · International Journal of Cosmetic Science · doi:10.1111/ics.12651 · Cited by 47 · see citing works
Alalaiwe, A. S., Lin, Y., Lin, C.-H., Wang, P., Lin, J.-Y., & Fang, J. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126955 · Cited by 41 · see citing works
Skin inflammation induced by ambient particulate matter in China
Dong, Y., Liao, L.-Y., Li, L., Yi, F., Meng, H., He, Y., & Guo, M. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.155 · Cited by 39 · see citing works
Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
Sguizzato, M., Mariani, P., Ferrara, F., Drechsler, M., Hallan, S. S., Huang, N., Simelière, F., Khunti, N. S., Cortesi, R., Marchetti, N., et al. (2020) · Nanomaterials · doi:10.3390/nano10050961 · Cited by 38 · see citing works
Self-citationLan, J., Huang, Q., Yang, L., Li, Y., Yang, J., Jiang, B., Zhao, L., Xia, Y., Yu, X., & Tao, J. (2023) · British Journal of Dermatology · doi:10.1093/bjd/ljac124 · Cited by 36 · see citing works
Mokrzynski, K. T., Krzysztynska‐Kuleta, O. I., Zawrotniak, M., Sarna, M., & Sarna, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910645 · Cited by 32 · see citing works
Yang, C.-Y., Pan, C.-C., Tseng, C.-H., & Yen, F. (2022) · Antioxidants · doi:10.3390/antiox11112304 · Cited by 28 · see citing works
Moon, J., Ngoc, L. T. N., Chae, M., Tran, V. V., & Lee, Y. (2020) · Antioxidants · doi:10.3390/antiox9040271 · Cited by 28 · see citing works
Fusco, L., Pelin, M., Mukherjee, S. P., Keshavan, S., Sosa, S., Martín, C., González, V. J., Vázquez, E., Prato, M., Fadeel, B., et al. (2019) · Carbon · doi:10.1016/j.carbon.2019.12.064 · Cited by 24 · see citing works
Bielfeldt, S., Springmann, G., Seise, M., Wilhelm, K., & Callaghan, T. (2018) · International Journal of Cosmetic Science · doi:10.1111/ics.12484 · Cited by 25 · see citing works
Tisato, V., Gallo, S., Melloni, E., Celeghini, C., Passaro, A., Zauli, G., Secchiero, P., Bergamini, C. M., Trentini, A., Bonaccorsi, G., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/9629537 · Cited by 23 · see citing works
Self-citationSguizzato, M., Ferrara, F., Mariani, P., Pepe, A., Cortesi, R., Huang, N., Simelière, F., Boldrini, P., Baldisserotto, A., Valacchi, G., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081124 · Cited by 21 · see citing works
Self-citationPozzetti, L., Ferrara, F., Marotta, L., Gemma, S., Butini, S., Benedusi, M., Fusi, F., Ahmed, A., Pomponi, S., Ferrari, S., et al. (2022) · Antioxidants · doi:10.3390/antiox11030437 · Cited by 21 · see citing works
Self-citationCervellati, F., Woodby, B. L., Benedusi, M., Ferrara, F., Guiotto, A., & Valacchi, G. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-09412-w · Cited by 19 · see citing works
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Self-citationSchiavone, M. L., Pecorelli, A., Woodby, B. L., Ferrara, F., Pambianchi, E., Santucci, A., & Valacchi, G. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108416 · Cited by 11 · see citing works
Self-citationCircadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis
Frigato, E., Benedusi, M., Guiotto, A., Bertolucci, C., & Valacchi, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2309437 · Cited by 10 · see citing works
Self-citationJeong, M., Ju, Y., Kwon, H., Kim, Y., Hyun, K., & Choi, G. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45070376 · Cited by 10 · see citing works
Wu, P., Iwahashi, H., Xie, H., Wang, Y., Zhou, Y., Kiso, A., Kawashima, Y., & Wei, X. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00336-1 · Cited by 8 · see citing works
Kwack, M. H., Ha, N. G., & Lee, W. J. (2022) · Annals of Dermatology · doi:10.5021/ad.2022.34.3.163 · Cited by 8 · see citing works
Maunjumpon, P., Thamsermsang, O., & Panich, U. (2026) · Redox Report · doi:10.1080/13510002.2026.2629079 · Cited by 7 · see citing works
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Vaccarella, E., Piacentini, D., Falasca, G., Canepari, S., & Massimi, L. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165694 · Cited by 6 · see citing works
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Madecassoside alleviates PM2.5-induced skin cell damage
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Ivarsson, J., Yan, X., Guiotto, A., Pecorelli, A., Sarandy, M. M., Lynch, S., Anderias, S., Choudhary, H., White, S., Ferrara, F., et al. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70306 · Cited by 4 · see citing works
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Self-citation
- Authors
- Romani, A., Cervellati, C., Muresan, X. M., Belmonte, G., Pecorelli, A., Cervellati, F., Benedusi, M., Evelson, P., & Valacchi, G.
- Affiliations
- University of Ferrara (IT)
- North Carolina State University (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Valacchi, G.
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 172
- Pages
- 86-95
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2768046897
- Cited by
- 52
- References
- 53
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 12 · 2019: 11 · 2018: 2
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (publishedVersion, cc-by-nc-sa)
- Conicet (submittedVersion, cc-by-nc-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- particulate matter, air pollution, keratinocytes, oxidative stress, lipid peroxidation, 4-hydroxynonenal, IL-1α, NF-kB, Nrf2, antioxidant response element, skin inflammation, HaCaT keratinocytes
- MeSH terms
- Cell Line, Transformed, Humans, Oxidation-Reduction, Keratinocytes, NF-kappa B, NF-E2-Related Factor 2, Particulate Matter, Interleukin-1alpha
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