The DOI matches its Crossref record; 177 of the 181 references it cites were found in a registry or an index.
The P2X7 receptor: A main player in inflammation
Open accessAbstract
Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and conserved DAMPs is extracellular ATP that exerts its phlogistic activity mainly through activation of the P2X7 receptor (P2X7R). The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an overview of recent and established literature on the role of P2X7R in septic and sterile inflammation. P2X7R ability in restraining intracellular bacteria and parasite infection by modulation of the immune response are described, with particular focus on Mycobacteria and Plasmodium. Emerging literature on the role of P2X7 in viral infections such as HIV-1 is also briefly covered. Finally, we describe the numerous intracellular pathways related to inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, NFAT, GSK3β and VEGF, and discuss the involvement of P2X7R in chronic diseases. The possible therapeutic applications of P2X7R antagonists are also described.
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“their activation induced by viral infection leads to molecular (mainly neuroimmune response activation, reactive oxygen species (ROS) formation, and glutamate release) and behavioral alterations [17, 20] as well as to mental disorders [21].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]
In the citing paper
“Consequently, there is an activation of caspase-1 and maturation of IL-1β and IL-18, resulting in pro-inflammatory cytokine release [16, 20, 52, 71, 73].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]
In the citing paper
“The P2X7 receptor, as a central player in inflammation, participates in viral infections. Exerting mostly pro-inflammatory roles [20], the P2X7 receptor is important for pathogen elimination [108], but on the other hand, its activation may be detrimental to the host due to the induction of exacerbated inflammatory responses.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]
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Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
Hemonnot, A.-L., Hua, J., Ulmann, L., & Hirbec, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00233 · Cited by 298
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity
Li, X.-Y., Moesta, A. K., Xiao, C., Nakamura, K., Casey, M., Zhang, H., Madore, J., Lepletier, A., Aguilera, A. R., Sundarrajan, A., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0541 · Cited by 269
Role of the NLRP3 inflammasome in autoimmune diseases
Li, Z., Guo, J., & Bi, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110542 · Cited by 276
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Metadata
- Authors
- Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F.
- Affiliations
- University of Ferrara (IT)
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 151
- Pages
- 234-244
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2779261291
- Cited by
- 385
- References
- 181
- Citations by year
- 2026: 35 · 2025: 40 · 2024: 43 · 2023: 54 · 2022: 61 · 2021: 60 · 2020: 46 · 2019: 26 · 2018: 20
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
- Funders
- Italian Association for Cancer Research (IG 13025, IG 18581)
- Ministry of Health of Italy (RF-2011-02348435)
- University of Ferrara
- AIRC (IG 16812)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- P2X7 receptor, extracellular ATP, damage-associated molecular patterns, sepsis, sterile inflammation, Mycobacterium, Plasmodium, HIV-1, NLRP3 inflammasome, NF-kB, NFAT, GSK3β, vascular endothelial growth factor, chronic disease, P2X7 receptor antagonists, innate immunity
- MeSH terms
- Animals, Autoimmune Diseases, Chronic Disease, Clinical Trials as Topic, Communicable Diseases, Drug Evaluation, Preclinical, Humans, Inflammation, Neoplasms, Neurodegenerative Diseases, Receptors, Purinergic P2X7, Inflammasomes, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists
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