Cited by 385Adenosine and Purinergic SignalingImmune Response and InflammationInflammasome and immune disorders

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The P2X7 receptor: A main player in inflammation

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Adinolfi, Elena, Giuliani, Anna Lisa, De Marchi, Elena, Pegoraro, Anna, Orioli, Elisa, Di Virgilio, Francesco·2018·Biochemical Pharmacology

DOI 10.1016/j.bcp.2017.12.021

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Abstract

Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and conserved DAMPs is extracellular ATP that exerts its phlogistic activity mainly through activation of the P2X7 receptor (P2X7R). The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an overview of recent and established literature on the role of P2X7R in septic and sterile inflammation. P2X7R ability in restraining intracellular bacteria and parasite infection by modulation of the immune response are described, with particular focus on Mycobacteria and Plasmodium. Emerging literature on the role of P2X7 in viral infections such as HIV-1 is also briefly covered. Finally, we describe the numerous intracellular pathways related to inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, NFAT, GSK3β and VEGF, and discuss the involvement of P2X7R in chronic diseases. The possible therapeutic applications of P2X7R antagonists are also described.

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Authors: Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F.
Affiliations: University of Ferrara (IT)
ORCID: Adinolfi, Elena
Giuliani, Anna Lisa
Pegoraro, Anna
Orioli, Elisa
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 2018-05
Volume: 151
Pages: 234-244
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/j.bcp.2017.12.021
OpenAlex: W2779261291
Cited by: 385
References: 181
Citations by year: 2026: 35 · 2025: 40 · 2024: 43 · 2023: 54 · 2022: 61 · 2021: 60 · 2020: 46 · 2019: 26 · 2018: 20
FWCI: 2.65
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
Funders: Italian Association for Cancer Research (IG 13025, IG 18581)
Ministry of Health of Italy (RF-2011-02348435)
University of Ferrara
AIRC (IG 16812)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: P2X7 receptor, extracellular ATP, damage-associated molecular patterns, sepsis, sterile inflammation, Mycobacterium, Plasmodium, HIV-1, NLRP3 inflammasome, NF-kB, NFAT, GSK3β, vascular endothelial growth factor, chronic disease, P2X7 receptor antagonists, innate immunity
MeSH terms: Animals, Autoimmune Diseases, Chronic Disease, Clinical Trials as Topic, Communicable Diseases, Drug Evaluation, Preclinical, Humans, Inflammation, Neoplasms, Neurodegenerative Diseases, Receptors, Purinergic P2X7, Inflammasomes, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists

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The P2X7 receptor: A main player in inflammation

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