Cited by 385Adenosine and Purinergic SignalingImmune Response and InflammationInflammasome and immune disorders

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The P2X7 receptor: A main player in inflammation

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Adinolfi, Elena, Giuliani, Anna Lisa, De Marchi, Elena, Pegoraro, Anna, Orioli, Elisa, Di Virgilio, Francesco·2018·Biochemical Pharmacology

DOI 10.1016/j.bcp.2017.12.021

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Abstract

Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and conserved DAMPs is extracellular ATP that exerts its phlogistic activity mainly through activation of the P2X7 receptor (P2X7R). The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an overview of recent and established literature on the role of P2X7R in septic and sterile inflammation. P2X7R ability in restraining intracellular bacteria and parasite infection by modulation of the immune response are described, with particular focus on Mycobacteria and Plasmodium. Emerging literature on the role of P2X7 in viral infections such as HIV-1 is also briefly covered. Finally, we describe the numerous intracellular pathways related to inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, NFAT, GSK3β and VEGF, and discuss the involvement of P2X7R in chronic diseases. The possible therapeutic applications of P2X7R antagonists are also described.

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ILr1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages
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P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii , by Human and Murine Macrophages
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Microglial P2X7receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
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Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor‐independent mechanisms
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Spinal cord pathology is ameliorated by P2X7 antagonism in SOD1-G93A mouse model of amyotrophic lateral sclerosis
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The P2X7 Receptor is an Important Regulator of Extracellular ATP Levels
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Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles
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Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
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Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7
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Expression of the P2X7 Receptor Increases the Ca2+ Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis
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Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes
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Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors
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A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma
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Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection
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Protective effect of apigenin on Freund’s complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway
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Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis
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Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages
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Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
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Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
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Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
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Effect of P2Y12 inhibitors on inflammation and immunity
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The P2X7 receptor–inflammasome complex has a role in modulating the inflammatory response in primary S jögren's syndrome
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Pyroptosis: Caspase-11 Unlocks the Gates of Death
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The Antibiotic Polymyxin B Modulates P2X7 Receptor Function
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P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice
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Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis
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Modulation of P2X7 purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination
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Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection
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Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
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P2X Receptors and Inflammation
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The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases
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Prophylactic systemic P2X7 receptor blockade prevents experimental colitis
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Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
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Dysfunctional inflammasome in Schnitzler's syndrome
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Ca2+/calmodulin‐dependent kinase II signalling cascade mediates P2X7 receptor‐dependent inhibition of neuritogenesis in neuroblastoma cells
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Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
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Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions
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Involvement of the Purinergic P2X7 Receptor in the Formation of Multinucleated Giant Cells
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Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death
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P2X7 blockade attenuates mouse liver fibrosis
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P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria
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P2X7 receptor positively regulates MyD88-dependent NF-κB activation
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Effect of the Purinergic Receptor P2X7 on Chlamydia Infection in Cervical Epithelial Cells and Vaginally Infected Mice
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Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
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Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7
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Emerging Roles of P2X Receptors in Cancer
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Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death
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Purinergic Receptor Functionality Is Necessary for Infection of Human Hepatocytes by Hepatitis Delta Virus and Hepatitis B Virus
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Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation
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HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation
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P2 receptors in cancer progression and metastatic spreading
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Bridging hypoxia, inflammation and estrogen receptors in thyroid cancer progression
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Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P 2 X 7 receptors
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Exogenous ATP enhances calcium influx in intact thymocytes.
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The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis
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Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice
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P2X7 receptor gene polymorphism analysis in rheumatoid arthritis
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Comparative study of the P2X gene family in animals and plants
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The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes
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Involvement of the P2X7 Purinergic Receptor and c-Jun N-Terminal and Extracellular Signal-Regulated Kinases in Cyclooxygenase-2 and Prostaglandin E2 Induction by LL-37
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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
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Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
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Cathelicidin LL‐37 induces time‐resolved release of LTB 4 and TXA 2 by human macrophages and triggers eicosanoid generation in vivo
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The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control
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Novel P2X7 receptor antagonists ease the pain
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Purinergic Signaling Induces Cyclooxygenase-1-Dependent Prostanoid Synthesis in Microglia: Roles in the Outcome of Excitotoxic Brain Injury
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Tenidap enhances P2Z/P2X7 receptor signalling in macrophages
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P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations
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Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation
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Authors: Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F.
Affiliations: University of Ferrara (IT)
ORCID: Adinolfi, Elena
Giuliani, Anna Lisa
Pegoraro, Anna
Orioli, Elisa
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 2018-05
Volume: 151
Pages: 234-244
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/j.bcp.2017.12.021
OpenAlex: W2779261291
Cited by: 385
References: 181
Citations by year: 2026: 35 · 2025: 40 · 2024: 43 · 2023: 54 · 2022: 61 · 2021: 60 · 2020: 46 · 2019: 26 · 2018: 20
FWCI: 2.65
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
Funders: Italian Association for Cancer Research (IG 13025, IG 18581)
Ministry of Health of Italy (RF-2011-02348435)
University of Ferrara
AIRC (IG 16812)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: P2X7 receptor, extracellular ATP, damage-associated molecular patterns, sepsis, sterile inflammation, Mycobacterium, Plasmodium, HIV-1, NLRP3 inflammasome, NF-kB, NFAT, GSK3β, vascular endothelial growth factor, chronic disease, P2X7 receptor antagonists, innate immunity
MeSH terms: Animals, Autoimmune Diseases, Chronic Disease, Clinical Trials as Topic, Communicable Diseases, Drug Evaluation, Preclinical, Humans, Inflammation, Neoplasms, Neurodegenerative Diseases, Receptors, Purinergic P2X7, Inflammasomes, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists

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The P2X7 receptor: A main player in inflammation

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